SNRPC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0000395Biological processmRNA 5'-splice site recognition
GO_0000387Biological processspliceosomal snRNP assembly
GO_0015030Cellular componentCajal body
GO_0000243Cellular componentcommitment complex
GO_0071004Cellular componentU2-type prespliceosome
GO_0005654Cellular componentnucleoplasm
GO_0005685Cellular componentU1 snRNP
GO_0005681Cellular componentspliceosomal complex
GO_0005634Cellular componentnucleus
GO_0003729Molecular functionmRNA binding
GO_0030627Molecular functionpre-mRNA 5'-splice site binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0030619Molecular functionU1 snRNA binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameSNRPC
Protein nameSmall nuclear ribonucleoprotein polypeptide C
U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C)
SynonymshCG_16077
DescriptionFUNCTION: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. .

FUNCTION: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. .; FUNCTION: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. .

FUNCTION: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. .; FUNCTION: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. .

AccessionsA0A0A0MRR7
ENST00000244520.10
Q5TAL4
ENST00000374017.3
ENST00000374018.5
Q5TAL2
P09234