SEC11A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	39 studies	47% ± 15%	Explore
endothelial cell	39 studies	43% ± 19%	Explore
natural killer cell	36 studies	38% ± 12%	Explore
fibroblast	36 studies	47% ± 16%	Explore
B cell	33 studies	28% ± 9%	Explore
CD8-positive, alpha-beta T cell	30 studies	32% ± 15%	Explore
conventional dendritic cell	28 studies	58% ± 13%	Explore
CD4-positive, alpha-beta T cell	28 studies	31% ± 14%	Explore
T cell	27 studies	31% ± 12%	Explore
classical monocyte	26 studies	50% ± 14%	Explore
dendritic cell	25 studies	49% ± 19%	Explore
smooth muscle cell	24 studies	34% ± 11%	Explore
pericyte	24 studies	39% ± 15%	Explore
non-classical monocyte	23 studies	61% ± 16%	Explore
regulatory T cell	23 studies	36% ± 11%	Explore
endothelial cell of lymphatic vessel	22 studies	48% ± 17%	Explore
mast cell	21 studies	46% ± 18%	Explore
monocyte	21 studies	47% ± 15%	Explore
memory B cell	20 studies	25% ± 6%	Explore
epithelial cell	20 studies	47% ± 22%	Explore
plasmacytoid dendritic cell	19 studies	31% ± 12%	Explore
basal cell	19 studies	37% ± 21%	Explore
connective tissue cell	19 studies	49% ± 17%	Explore
mature NK T cell	17 studies	33% ± 9%	Explore
gamma-delta T cell	17 studies	34% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	40% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	38% ± 12%	Explore
naive B cell	15 studies	24% ± 5%	Explore
plasma cell	14 studies	41% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	25% ± 7%	Explore
myofibroblast cell	14 studies	45% ± 16%	Explore
myeloid cell	13 studies	47% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	30% ± 15%	Explore
capillary endothelial cell	12 studies	34% ± 16%	Explore
endothelial cell of artery	12 studies	39% ± 15%	Explore
vein endothelial cell	12 studies	45% ± 17%	Explore
endothelial cell of vascular tree	12 studies	42% ± 12%	Explore
ciliated cell	12 studies	39% ± 20%	Explore
plasmablast	11 studies	46% ± 22%	Explore
secretory cell	11 studies	43% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	32% ± 9%	Explore
mucosal invariant T cell	11 studies	27% ± 6%	Explore
type I pneumocyte	10 studies	35% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	33% ± 14%	Explore
abnormal cell	10 studies	42% ± 15%	Explore
mesothelial cell	10 studies	55% ± 19%	Explore
type II pneumocyte	9 studies	41% ± 18%	Explore
leukocyte	9 studies	45% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	31% ± 10%	Explore
progenitor cell	9 studies	49% ± 16%	Explore
goblet cell	9 studies	32% ± 14%	Explore
adipocyte	9 studies	25% ± 5%	Explore
alveolar macrophage	8 studies	56% ± 21%	Explore
innate lymphoid cell	8 studies	44% ± 11%	Explore
club cell	8 studies	34% ± 17%	Explore
microglial cell	8 studies	30% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	41% ± 17%	Explore
epithelial cell of proximal tubule	7 studies	33% ± 14%	Explore
neuron	7 studies	47% ± 19%	Explore
astrocyte	7 studies	29% ± 9%	Explore
T follicular helper cell	7 studies	31% ± 9%	Explore
hematopoietic precursor cell	6 studies	46% ± 15%	Explore
mononuclear phagocyte	6 studies	55% ± 22%	Explore
kidney loop of Henle epithelial cell	6 studies	31% ± 8%	Explore
renal alpha-intercalated cell	6 studies	61% ± 5%	Explore
transit amplifying cell	6 studies	29% ± 9%	Explore
precursor B cell	6 studies	29% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	37% ± 18%	Explore
enteroendocrine cell	5 studies	49% ± 18%	Explore
intestinal crypt stem cell	5 studies	29% ± 8%	Explore
erythroblast	5 studies	36% ± 18%	Explore
hematopoietic stem cell	5 studies	41% ± 11%	Explore
lymphocyte	5 studies	43% ± 20%	Explore
neutrophil	5 studies	24% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	48% ± 18%	Explore
intermediate monocyte	5 studies	59% ± 22%	Explore
granulocyte	5 studies	40% ± 13%	Explore
oligodendrocyte	5 studies	21% ± 4%	Explore
pancreatic A cell	4 studies	52% ± 14%	Explore
type B pancreatic cell	4 studies	57% ± 20%	Explore
exhausted T cell	4 studies	50% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	59% ± 17%	Explore
enterocyte	4 studies	28% ± 9%	Explore
IgA plasma cell	4 studies	25% ± 8%	Explore
pro-B cell	4 studies	29% ± 3%	Explore
adventitial cell	4 studies	43% ± 6%	Explore
acinar cell	4 studies	33% ± 18%	Explore
muscle cell	4 studies	32% ± 15%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	44% ± 5%	Explore
GABAergic neuron	4 studies	31% ± 8%	Explore
glutamatergic neuron	4 studies	37% ± 10%	Explore
oligodendrocyte precursor cell	4 studies	35% ± 18%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	59% ± 25%	Explore
hepatocyte	4 studies	44% ± 28%	Explore
erythrocyte	4 studies	32% ± 16%	Explore
group 3 innate lymphoid cell	4 studies	59% ± 12%	Explore
T-helper 17 cell	4 studies	38% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	31% ± 7%	Explore
duct epithelial cell	3 studies	19% ± 2%	Explore
ionocyte	3 studies	36% ± 8%	Explore
precursor cell	3 studies	52% ± 23%	Explore
respiratory goblet cell	3 studies	35% ± 21%	Explore
pancreatic D cell	3 studies	56% ± 17%	Explore
monocyte-derived dendritic cell	3 studies	66% ± 14%	Explore
glomerular endothelial cell	3 studies	23% ± 5%	Explore
neural crest cell	3 studies	70% ± 6%	Explore
IgG plasma cell	3 studies	23% ± 10%	Explore
extravillous trophoblast	3 studies	83% ± 6%	Explore
placental villous trophoblast	3 studies	70% ± 5%	Explore
megakaryocyte	3 studies	39% ± 1%	Explore
Schwann cell	3 studies	43% ± 23%	Explore
immature B cell	3 studies	27% ± 2%	Explore
serous secreting cell	3 studies	21% ± 1%	Explore
tissue-resident macrophage	3 studies	37% ± 12%	Explore
intraepithelial lymphocyte	3 studies	38% ± 12%	Explore
Mueller cell	3 studies	24% ± 5%	Explore
germinal center B cell	3 studies	25% ± 2%	Explore
CD4-positive helper T cell	3 studies	23% ± 5%	Explore
myoepithelial cell	3 studies	49% ± 18%	Explore
inflammatory macrophage	3 studies	40% ± 9%	Explore
luminal cell of prostate epithelium	3 studies	25% ± 9%	Explore
pancreatic ductal cell	3 studies	68% ± 6%	Explore
glial cell	3 studies	48% ± 25%	Explore
melanocyte	3 studies	30% ± 11%	Explore
keratinocyte	3 studies	19% ± 2%	Explore
interneuron	3 studies	31% ± 15%	Explore
T-helper 1 cell	3 studies	40% ± 14%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	27% ± 9%	Explore
double negative thymocyte	3 studies	43% ± 12%	Explore
progenitor cell of mammary luminal epithelium	3 studies	34% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	42% ± 16%	Explore
peripheral blood	18 studies	37% ± 11%	Explore
intestine	11 studies	36% ± 17%	Explore
kidney	9 studies	39% ± 13%	Explore
brain	8 studies	29% ± 8%	Explore
liver	7 studies	34% ± 17%	Explore
bone marrow	5 studies	31% ± 13%	Explore
eye	5 studies	27% ± 9%	Explore
lymph node	5 studies	38% ± 18%	Explore
pancreas	4 studies	56% ± 16%	Explore
placenta	4 studies	57% ± 25%	Explore
uterus	4 studies	58% ± 13%	Explore
breast	4 studies	41% ± 4%	Explore
adrenal gland	3 studies	26% ± 6%	Explore
prostate	3 studies	26% ± 7%	Explore
adipose	3 studies	27% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	5343.66	89 / 89	100%	61.28	901 / 901
liver	100%	2810.31	226 / 226	100%	49.78	406 / 406
ovary	100%	6425.30	180 / 180	100%	61.38	430 / 430
pancreas	100%	3648.99	328 / 328	100%	64.40	178 / 178
prostate	100%	4208.22	245 / 245	100%	65.87	502 / 502
stomach	100%	3699.43	359 / 359	100%	47.80	286 / 286
uterus	100%	5269.85	170 / 170	100%	75.79	459 / 459
thymus	100%	5907.58	653 / 653	100%	96.80	604 / 605
lung	100%	5467.60	578 / 578	100%	66.80	1153 / 1155
breast	100%	6943.32	459 / 459	100%	77.41	1116 / 1118
intestine	100%	4487.08	966 / 966	100%	55.64	526 / 527
bladder	100%	5104.19	21 / 21	100%	65.58	503 / 504
skin	100%	5418.90	1809 / 1809	100%	82.24	471 / 472
esophagus	100%	3763.63	1445 / 1445	99%	41.05	182 / 183
adrenal gland	100%	6452.95	258 / 258	99%	58.12	227 / 230
brain	97%	1800.38	2568 / 2642	100%	57.55	704 / 705
adipose	100%	7376.36	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5371.48	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	58.56	29 / 29
muscle	100%	4359.75	803 / 803	0%	0	0 / 0
spleen	100%	4198.84	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	51.85	45 / 45
ureter	0%	0	0 / 0	100%	42.53	1 / 1
eye	0%	0	0 / 0	99%	74.32	79 / 80
heart	98%	2937.81	844 / 861	0%	0	0 / 0
peripheral blood	94%	3177.62	870 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	SEC11A
Protein name	Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18) Signal peptidase complex catalytic subunit SEC11 (EC 3.4.21.89) Signal peptidase complex catalytic subunit SEC11 (Signal peptidase complex catalytic subunit sec11) Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18)
Synonyms	SPCS4A SPC18 SEC11L1
Description	FUNCTION: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum . Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids . .
Accessions	ENST00000455959.7 [P67812-2] ENST00000560409.5 H0YNG3 H0YNX5 H0YKT4 P67812 ENST00000560266.5 [P67812-4] ENST00000268220.12 [P67812-1] ENST00000558196.1 ENST00000558134.5 [P67812-3] ENST00000558217.5 H0YNA5 ENST00000559729.5

GO_0006465	Biological process	signal peptide processing
GO_0009615	Biological process	response to virus
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005787	Cellular component	signal peptidase complex
GO_0008233	Molecular function	peptidase activity
GO_0005515	Molecular function	protein binding
GO_0004252	Molecular function	serine-type endopeptidase activity

SEC11A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review