RSF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	46 studies	32% ± 12%	Explore
fibroblast	37 studies	28% ± 9%	Explore
natural killer cell	33 studies	26% ± 8%	Explore
pericyte	33 studies	28% ± 10%	Explore
B cell	32 studies	27% ± 8%	Explore
CD8-positive, alpha-beta T cell	27 studies	25% ± 8%	Explore
smooth muscle cell	26 studies	28% ± 7%	Explore
CD4-positive, alpha-beta T cell	26 studies	24% ± 8%	Explore
T cell	24 studies	26% ± 7%	Explore
macrophage	23 studies	26% ± 12%	Explore
regulatory T cell	22 studies	26% ± 6%	Explore
naive B cell	19 studies	26% ± 6%	Explore
astrocyte	19 studies	35% ± 18%	Explore
memory B cell	18 studies	26% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	26% ± 8%	Explore
gamma-delta T cell	16 studies	29% ± 10%	Explore
mast cell	15 studies	24% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	30% ± 8%	Explore
basal cell	15 studies	31% ± 15%	Explore
ciliated cell	15 studies	27% ± 10%	Explore
oligodendrocyte precursor cell	15 studies	39% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	27% ± 7%	Explore
mature NK T cell	15 studies	24% ± 6%	Explore
endothelial cell of lymphatic vessel	14 studies	27% ± 8%	Explore
capillary endothelial cell	14 studies	25% ± 9%	Explore
epithelial cell	14 studies	36% ± 20%	Explore
mucosal invariant T cell	14 studies	24% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	27% ± 10%	Explore
myofibroblast cell	13 studies	30% ± 10%	Explore
connective tissue cell	13 studies	30% ± 10%	Explore
oligodendrocyte	13 studies	36% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	30% ± 8%	Explore
classical monocyte	12 studies	22% ± 9%	Explore
glutamatergic neuron	12 studies	48% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	31% ± 8%	Explore
microglial cell	12 studies	33% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	26% ± 9%	Explore
GABAergic neuron	11 studies	45% ± 22%	Explore
endothelial cell of artery	11 studies	23% ± 5%	Explore
vein endothelial cell	11 studies	27% ± 12%	Explore
plasmacytoid dendritic cell	11 studies	26% ± 8%	Explore
type I pneumocyte	10 studies	30% ± 7%	Explore
non-classical monocyte	10 studies	24% ± 11%	Explore
neuron	10 studies	47% ± 16%	Explore
dendritic cell	10 studies	31% ± 15%	Explore
endothelial cell of vascular tree	10 studies	26% ± 11%	Explore
club cell	9 studies	29% ± 9%	Explore
conventional dendritic cell	9 studies	26% ± 14%	Explore
mesothelial cell	9 studies	34% ± 9%	Explore
adipocyte	9 studies	27% ± 6%	Explore
abnormal cell	8 studies	30% ± 8%	Explore
amacrine cell	8 studies	39% ± 12%	Explore
myeloid cell	8 studies	27% ± 7%	Explore
progenitor cell	7 studies	28% ± 9%	Explore
retinal ganglion cell	7 studies	36% ± 17%	Explore
type II pneumocyte	7 studies	29% ± 6%	Explore
retinal cone cell	7 studies	26% ± 7%	Explore
retinal rod cell	7 studies	26% ± 4%	Explore
T follicular helper cell	7 studies	23% ± 5%	Explore
monocyte	7 studies	28% ± 9%	Explore
respiratory goblet cell	6 studies	29% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	22% ± 5%	Explore
leukocyte	6 studies	29% ± 7%	Explore
interneuron	6 studies	57% ± 21%	Explore
hematopoietic stem cell	6 studies	31% ± 13%	Explore
precursor B cell	6 studies	35% ± 10%	Explore
retina horizontal cell	6 studies	44% ± 10%	Explore
Mueller cell	6 studies	34% ± 5%	Explore
hematopoietic precursor cell	5 studies	35% ± 16%	Explore
secretory cell	5 studies	33% ± 7%	Explore
retinal bipolar neuron	5 studies	32% ± 8%	Explore
pro-B cell	5 studies	34% ± 6%	Explore
plasma cell	5 studies	32% ± 8%	Explore
brush cell	5 studies	29% ± 12%	Explore
cardiac muscle cell	5 studies	28% ± 3%	Explore
lymphocyte	5 studies	40% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	30% ± 12%	Explore
innate lymphoid cell	5 studies	25% ± 3%	Explore
goblet cell	5 studies	34% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	26% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	26% ± 6%	Explore
exhausted T cell	4 studies	31% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	21% ± 4%	Explore
glial cell	4 studies	33% ± 12%	Explore
granule cell	4 studies	39% ± 5%	Explore
immature B cell	4 studies	30% ± 5%	Explore
mononuclear phagocyte	4 studies	24% ± 9%	Explore
OFF-bipolar cell	4 studies	29% ± 6%	Explore
ON-bipolar cell	4 studies	30% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	23% ± 7%	Explore
myoepithelial cell	4 studies	33% ± 9%	Explore
muscle cell	4 studies	32% ± 17%	Explore
enteroendocrine cell	4 studies	31% ± 10%	Explore
ionocyte	3 studies	32% ± 6%	Explore
squamous epithelial cell	3 studies	37% ± 26%	Explore
pancreatic A cell	3 studies	35% ± 9%	Explore
plasmablast	3 studies	40% ± 15%	Explore
glomerular endothelial cell	3 studies	24% ± 5%	Explore
podocyte	3 studies	27% ± 5%	Explore
neural crest cell	3 studies	32% ± 6%	Explore
GABAergic interneuron	3 studies	41% ± 4%	Explore
GABAergic amacrine cell	3 studies	40% ± 4%	Explore
glycinergic amacrine cell	3 studies	31% ± 2%	Explore
rod bipolar cell	3 studies	40% ± 1%	Explore
CD4-positive helper T cell	3 studies	24% ± 4%	Explore
hepatocyte	3 studies	31% ± 13%	Explore
ependymal cell	3 studies	36% ± 16%	Explore
granulocyte	3 studies	25% ± 11%	Explore
intestinal crypt stem cell	3 studies	19% ± 3%	Explore
adventitial cell	3 studies	23% ± 2%	Explore
alveolar macrophage	3 studies	30% ± 8%	Explore
chondrocyte	3 studies	27% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 8%	Explore
transit amplifying cell	3 studies	38% ± 32%	Explore
T-helper 17 cell	3 studies	21% ± 2%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	24% ± 4%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	23% ± 3%	Explore
double negative thymocyte	3 studies	42% ± 13%	Explore
mural cell	3 studies	36% ± 12%	Explore
mucus secreting cell	3 studies	25% ± 7%	Explore
kidney loop of Henle epithelial cell	3 studies	20% ± 3%	Explore
renal principal cell	3 studies	21% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	41% ± 20%	Explore
lung	17 studies	26% ± 7%	Explore
peripheral blood	16 studies	26% ± 10%	Explore
eye	10 studies	31% ± 11%	Explore
intestine	7 studies	24% ± 9%	Explore
kidney	5 studies	26% ± 3%	Explore
heart	5 studies	25% ± 3%	Explore
lymph node	5 studies	26% ± 9%	Explore
liver	5 studies	28% ± 10%	Explore
bone marrow	4 studies	30% ± 11%	Explore
breast	4 studies	19% ± 4%	Explore
adipose	4 studies	32% ± 5%	Explore
pancreas	3 studies	32% ± 8%	Explore
uterus	3 studies	32% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2858.13	1445 / 1445	100%	17.24	183 / 183
brain	100%	2834.90	2640 / 2642	100%	20.33	704 / 705
ovary	100%	3895.23	180 / 180	100%	13.78	429 / 430
prostate	100%	2771.29	245 / 245	99%	13.25	499 / 502
lung	100%	2930.00	578 / 578	99%	13.03	1146 / 1155
breast	100%	3329.69	459 / 459	99%	22.39	1108 / 1118
thymus	100%	3323.84	653 / 653	99%	14.53	597 / 605
pancreas	99%	1260.34	325 / 328	99%	11.28	176 / 178
bladder	100%	3290.71	21 / 21	98%	10.30	493 / 504
uterus	100%	3804.25	170 / 170	97%	10.68	444 / 459
stomach	100%	2117.48	359 / 359	97%	11.89	276 / 286
intestine	100%	3126.19	966 / 966	95%	9.87	500 / 527
kidney	100%	1708.36	89 / 89	95%	10.81	854 / 901
adrenal gland	100%	4032.22	258 / 258	95%	11.65	218 / 230
skin	100%	3024.60	1808 / 1809	92%	13.58	435 / 472
liver	100%	995.73	225 / 226	60%	3.48	245 / 406
adipose	100%	3407.94	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4580.41	1335 / 1335	0%	0	0 / 0
spleen	100%	2504.80	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.23	1 / 1
muscle	100%	1897.78	800 / 803	0%	0	0 / 0
heart	97%	1672.35	836 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	7.78	28 / 29
tonsil	0%	0	0 / 0	93%	9.61	42 / 45
peripheral blood	84%	1666.74	781 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	63%	4.36	50 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0006338	Biological process	chromatin remodeling
GO_0050434	Biological process	positive regulation of viral transcription
GO_0006352	Biological process	DNA-templated transcription initiation
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0006334	Biological process	nucleosome assembly
GO_0043392	Biological process	negative regulation of DNA binding
GO_0005654	Cellular component	nucleoplasm
GO_0031213	Cellular component	RSF complex
GO_0005634	Cellular component	nucleus
GO_0042393	Molecular function	histone binding
GO_0140751	Molecular function	histone octamer slider activity
GO_0016887	Molecular function	ATP hydrolysis activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	RSF1
Protein name	RSF1 protein Remodeling and spacing factor 1 Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex)
Synonyms	XAP8 HBXAP
Description	FUNCTION: Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair . Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex . Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively . The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex . The complexes do not have the ability to slide mononucleosomes to the center of a DNA template . Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain . .
Accessions	Q96T23 ENST00000532556.1 ENST00000480887.5 [Q96T23-3] ENST00000440064.2 H0YCN2 ENST00000308488.11 [Q96T23-1] H0YDG9 ENST00000531026.5 H0YER1 H0YEX0 ENST00000528095.5 ENST00000526324.5 Q05DG0 H7C306

RSF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review