RNPS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0006351Biological processDNA-templated transcription
GO_0048025Biological processnegative regulation of mRNA splicing, via spliceosome
GO_0008380Biological processRNA splicing
GO_0043065Biological processpositive regulation of apoptotic process
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0016607Cellular componentnuclear speck
GO_0035145Cellular componentexon-exon junction complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0061574Cellular componentASAP complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameRNPS1
Protein nameRNA binding protein with serine rich domain 1
RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2)
RNA-binding protein with serine-rich domain 1
SynonymsLDC2
hCG_1989969
DescriptionFUNCTION: Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions. .

AccessionsQ15287
ENST00000567147.5
ENST00000568631.5 [Q15287-1]
ENST00000564822.1
ENST00000564764.5
ENST00000564601.5
H3BMM9
ENST00000562690.5
ENST00000566180.5
ENST00000566458.5 [Q15287-2]
H3BTV0
H3BUG0
ENST00000565589.5
H3BV80
ENST00000397086.6 [Q15287-1]
ENST00000564311.5
ENST00000565678.5 [Q15287-1]
H3BMS0
ENST00000566397.5
H3BTY0
ENST00000565870.5
ENST00000569709.5
H3BPG5
H3BNI3
H3BUL0
ENST00000301730.12 [Q15287-1]
H3BTC0
H3BNU7
ENST00000561518.5
ENST00000561718.5
ENST00000565333.5
H3BTR6
ENST00000320225.10 [Q15287-1]
ENST00000569598.6
H3BRK4
H3BP82