REEP5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	37 studies	32% ± 12%	Explore
fibroblast	37 studies	34% ± 13%	Explore
macrophage	33 studies	36% ± 14%	Explore
natural killer cell	32 studies	29% ± 8%	Explore
pericyte	31 studies	30% ± 10%	Explore
B cell	29 studies	28% ± 8%	Explore
T cell	27 studies	26% ± 8%	Explore
CD8-positive, alpha-beta T cell	27 studies	32% ± 13%	Explore
conventional dendritic cell	26 studies	37% ± 15%	Explore
classical monocyte	25 studies	39% ± 14%	Explore
smooth muscle cell	24 studies	26% ± 9%	Explore
non-classical monocyte	23 studies	45% ± 14%	Explore
plasma cell	22 studies	47% ± 21%	Explore
CD4-positive, alpha-beta T cell	22 studies	28% ± 12%	Explore
monocyte	21 studies	32% ± 10%	Explore
basal cell	20 studies	35% ± 18%	Explore
regulatory T cell	20 studies	33% ± 14%	Explore
endothelial cell of lymphatic vessel	18 studies	41% ± 14%	Explore
memory B cell	18 studies	25% ± 7%	Explore
epithelial cell	18 studies	38% ± 21%	Explore
naive B cell	18 studies	23% ± 6%	Explore
plasmacytoid dendritic cell	17 studies	33% ± 12%	Explore
ciliated cell	17 studies	38% ± 19%	Explore
mature NK T cell	16 studies	32% ± 6%	Explore
gamma-delta T cell	16 studies	31% ± 8%	Explore
dendritic cell	15 studies	39% ± 22%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	30% ± 8%	Explore
plasmablast	12 studies	49% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	33% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	30% ± 7%	Explore
capillary endothelial cell	12 studies	27% ± 4%	Explore
myofibroblast cell	12 studies	32% ± 11%	Explore
vein endothelial cell	12 studies	25% ± 7%	Explore
mucosal invariant T cell	12 studies	32% ± 9%	Explore
connective tissue cell	12 studies	34% ± 11%	Explore
myeloid cell	12 studies	34% ± 14%	Explore
mast cell	11 studies	21% ± 3%	Explore
secretory cell	11 studies	36% ± 17%	Explore
endothelial cell of vascular tree	11 studies	26% ± 8%	Explore
type I pneumocyte	10 studies	36% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	32% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	26% ± 7%	Explore
endothelial cell of artery	10 studies	28% ± 4%	Explore
glutamatergic neuron	10 studies	41% ± 21%	Explore
astrocyte	10 studies	28% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	32% ± 9%	Explore
abnormal cell	9 studies	37% ± 18%	Explore
alveolar macrophage	8 studies	44% ± 19%	Explore
club cell	8 studies	38% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	19% ± 3%	Explore
oligodendrocyte	8 studies	29% ± 8%	Explore
GABAergic neuron	8 studies	40% ± 21%	Explore
type II pneumocyte	7 studies	34% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	42% ± 18%	Explore
leukocyte	7 studies	27% ± 7%	Explore
neuron	7 studies	35% ± 11%	Explore
IgA plasma cell	7 studies	32% ± 13%	Explore
IgG plasma cell	7 studies	28% ± 12%	Explore
microglial cell	7 studies	26% ± 7%	Explore
ionocyte	6 studies	38% ± 14%	Explore
respiratory goblet cell	6 studies	39% ± 21%	Explore
mononuclear phagocyte	6 studies	34% ± 12%	Explore
renal alpha-intercalated cell	6 studies	48% ± 14%	Explore
innate lymphoid cell	6 studies	29% ± 2%	Explore
goblet cell	6 studies	31% ± 11%	Explore
T follicular helper cell	6 studies	20% ± 4%	Explore
oligodendrocyte precursor cell	6 studies	29% ± 8%	Explore
exhausted T cell	5 studies	48% ± 10%	Explore
kidney loop of Henle epithelial cell	5 studies	39% ± 13%	Explore
epithelial cell of proximal tubule	5 studies	22% ± 5%	Explore
retinal ganglion cell	5 studies	76% ± 26%	Explore
brush cell	5 studies	43% ± 18%	Explore
mucus secreting cell	5 studies	28% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	40% ± 19%	Explore
interneuron	5 studies	45% ± 23%	Explore
pancreatic A cell	4 studies	68% ± 15%	Explore
type B pancreatic cell	4 studies	67% ± 21%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	39% ± 15%	Explore
lymphocyte	4 studies	34% ± 14%	Explore
immature B cell	4 studies	28% ± 8%	Explore
amacrine cell	4 studies	35% ± 10%	Explore
retina horizontal cell	4 studies	34% ± 8%	Explore
adventitial cell	4 studies	30% ± 11%	Explore
cardiac muscle cell	4 studies	17% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	55% ± 11%	Explore
intermediate monocyte	4 studies	51% ± 15%	Explore
CD4-positive helper T cell	4 studies	23% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	72% ± 7%	Explore
luminal cell of prostate epithelium	4 studies	30% ± 8%	Explore
neutrophil	4 studies	21% ± 3%	Explore
enteroendocrine cell	4 studies	36% ± 18%	Explore
T-helper 17 cell	4 studies	36% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	33% ± 8%	Explore
duct epithelial cell	3 studies	42% ± 8%	Explore
squamous epithelial cell	3 studies	41% ± 24%	Explore
pancreatic D cell	3 studies	66% ± 20%	Explore
hematopoietic precursor cell	3 studies	25% ± 3%	Explore
glomerular endothelial cell	3 studies	27% ± 4%	Explore
podocyte	3 studies	42% ± 5%	Explore
progenitor cell	3 studies	22% ± 6%	Explore
retinal bipolar neuron	3 studies	31% ± 9%	Explore
renal principal cell	3 studies	58% ± 9%	Explore
extravillous trophoblast	3 studies	60% ± 7%	Explore
placental villous trophoblast	3 studies	72% ± 8%	Explore
precursor B cell	3 studies	34% ± 5%	Explore
pro-B cell	3 studies	25% ± 4%	Explore
retinal cone cell	3 studies	53% ± 10%	Explore
retinal rod cell	3 studies	25% ± 5%	Explore
serous secreting cell	3 studies	49% ± 11%	Explore
tissue-resident macrophage	3 studies	25% ± 9%	Explore
intraepithelial lymphocyte	3 studies	26% ± 4%	Explore
Mueller cell	3 studies	27% ± 4%	Explore
ON-bipolar cell	3 studies	49% ± 34%	Explore
rod bipolar cell	3 studies	29% ± 9%	Explore
germinal center B cell	3 studies	28% ± 5%	Explore
IgM plasma cell	3 studies	34% ± 11%	Explore
muscle cell	3 studies	31% ± 15%	Explore
acinar cell	3 studies	64% ± 19%	Explore
pancreatic ductal cell	3 studies	73% ± 10%	Explore
glial cell	3 studies	24% ± 10%	Explore
group 3 innate lymphoid cell	3 studies	38% ± 17%	Explore
transit amplifying cell	3 studies	20% ± 6%	Explore
keratinocyte	3 studies	21% ± 4%	Explore
T-helper 1 cell	3 studies	42% ± 19%	Explore
adipocyte	3 studies	30% ± 11%	Explore
double negative thymocyte	3 studies	34% ± 8%	Explore
progenitor cell of mammary luminal epithelium	3 studies	32% ± 5%	Explore
hepatocyte	3 studies	43% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	36% ± 14%	Explore
peripheral blood	18 studies	30% ± 9%	Explore
brain	15 studies	32% ± 17%	Explore
kidney	9 studies	30% ± 11%	Explore
intestine	8 studies	25% ± 9%	Explore
eye	7 studies	28% ± 8%	Explore
bone marrow	5 studies	20% ± 5%	Explore
lymph node	5 studies	29% ± 18%	Explore
liver	5 studies	31% ± 8%	Explore
pancreas	4 studies	68% ± 15%	Explore
uterus	4 studies	39% ± 14%	Explore
breast	4 studies	40% ± 2%	Explore
placenta	3 studies	55% ± 10%	Explore
adrenal gland	3 studies	29% ± 8%	Explore
esophagus	3 studies	35% ± 26%	Explore
prostate	3 studies	31% ± 7%	Explore
adipose	3 studies	23% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	7204.43	21 / 21	100%	121.20	504 / 504
kidney	100%	8608.25	89 / 89	100%	188.86	901 / 901
liver	100%	5676.81	226 / 226	100%	110.26	406 / 406
lung	100%	7842.00	578 / 578	100%	111.33	1155 / 1155
pancreas	100%	7055.62	328 / 328	100%	136.00	178 / 178
prostate	100%	8731.79	245 / 245	100%	210.32	502 / 502
thymus	100%	14864.55	653 / 653	100%	322.46	605 / 605
brain	100%	12962.16	2641 / 2642	100%	204.50	705 / 705
uterus	100%	7195.39	170 / 170	100%	107.81	458 / 459
adrenal gland	100%	11857.76	258 / 258	100%	220.62	229 / 230
breast	100%	10067.27	459 / 459	99%	257.45	1112 / 1118
esophagus	100%	5872.59	1445 / 1445	99%	90.26	182 / 183
stomach	100%	6124.67	359 / 359	99%	97.17	284 / 286
intestine	100%	6571.11	966 / 966	99%	99.71	523 / 527
ovary	100%	6681.32	180 / 180	99%	90.22	426 / 430
skin	100%	7313.87	1807 / 1809	98%	97.27	462 / 472
adipose	100%	8550.67	1204 / 1204	0%	0	0 / 0
blood vessel	100%	11907.81	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	89.97	29 / 29
muscle	100%	7645.53	803 / 803	0%	0	0 / 0
spleen	100%	5463.35	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	90.52	45 / 45
ureter	0%	0	0 / 0	100%	67.12	1 / 1
heart	98%	8103.66	842 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	74.37	75 / 80
peripheral blood	80%	3465.11	741 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	REEP5
Protein name	Receptor expression-enhancing protein Receptor accessory protein 5 (cDNA FLJ50528, moderately similar to Receptor expression-enhancing protein 5) Receptor expression-enhancing protein 5 (Polyposis locus protein 1) (Protein TB2)
Synonyms	DP1 TB2 C5orf18
Description	FUNCTION: Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes. . FUNCTION: Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes. . FUNCTION: Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes. . FUNCTION: Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes. .
Accessions	ENST00000513339.5 ENST00000504247.1 E2QRG8 ENST00000511865.6 B7Z510 B7Z332 ENST00000261482.8 Q00765 H0Y8J8 ENST00000379638.9 [Q00765-1]

GO_0007029	Biological process	endoplasmic reticulum organization
GO_0032386	Biological process	regulation of intracellular transport
GO_0008150	Biological process	biological_process
GO_0090158	Biological process	endoplasmic reticulum membrane organization
GO_0033017	Cellular component	sarcoplasmic reticulum membrane
GO_0071782	Cellular component	endoplasmic reticulum tubular network
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

REEP5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review