PSME2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	39 studies	53% ± 18%	Explore
B cell	36 studies	36% ± 13%	Explore
CD8-positive, alpha-beta T cell	36 studies	52% ± 21%	Explore
CD4-positive, alpha-beta T cell	32 studies	47% ± 19%	Explore
macrophage	31 studies	46% ± 19%	Explore
T cell	30 studies	46% ± 19%	Explore
endothelial cell	30 studies	37% ± 16%	Explore
fibroblast	30 studies	32% ± 14%	Explore
conventional dendritic cell	28 studies	62% ± 16%	Explore
regulatory T cell	27 studies	48% ± 20%	Explore
classical monocyte	24 studies	48% ± 18%	Explore
dendritic cell	23 studies	61% ± 19%	Explore
non-classical monocyte	23 studies	73% ± 15%	Explore
plasmacytoid dendritic cell	22 studies	54% ± 15%	Explore
mature NK T cell	20 studies	49% ± 17%	Explore
memory B cell	20 studies	35% ± 15%	Explore
plasma cell	20 studies	53% ± 23%	Explore
basal cell	20 studies	35% ± 17%	Explore
epithelial cell	20 studies	42% ± 21%	Explore
monocyte	19 studies	53% ± 15%	Explore
gamma-delta T cell	18 studies	49% ± 14%	Explore
pericyte	18 studies	27% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	37% ± 12%	Explore
naive B cell	17 studies	35% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	56% ± 17%	Explore
mucosal invariant T cell	16 studies	46% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	59% ± 14%	Explore
smooth muscle cell	16 studies	24% ± 11%	Explore
endothelial cell of lymphatic vessel	15 studies	37% ± 12%	Explore
ciliated cell	15 studies	39% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	47% ± 17%	Explore
mast cell	13 studies	23% ± 7%	Explore
connective tissue cell	13 studies	32% ± 10%	Explore
plasmablast	12 studies	68% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	48% ± 22%	Explore
capillary endothelial cell	12 studies	36% ± 8%	Explore
myeloid cell	12 studies	43% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	48% ± 22%	Explore
secretory cell	11 studies	38% ± 16%	Explore
vein endothelial cell	11 studies	33% ± 7%	Explore
endothelial cell of vascular tree	11 studies	37% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	48% ± 20%	Explore
endothelial cell of artery	10 studies	34% ± 8%	Explore
goblet cell	10 studies	36% ± 14%	Explore
innate lymphoid cell	9 studies	45% ± 14%	Explore
myofibroblast cell	9 studies	28% ± 9%	Explore
progenitor cell	9 studies	38% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	63% ± 25%	Explore
leukocyte	8 studies	37% ± 13%	Explore
enterocyte	8 studies	49% ± 21%	Explore
abnormal cell	8 studies	35% ± 8%	Explore
type I pneumocyte	7 studies	29% ± 14%	Explore
club cell	7 studies	41% ± 8%	Explore
epithelial cell of proximal tubule	7 studies	23% ± 4%	Explore
T follicular helper cell	7 studies	40% ± 12%	Explore
respiratory goblet cell	6 studies	47% ± 20%	Explore
kidney loop of Henle epithelial cell	6 studies	26% ± 3%	Explore
IgG plasma cell	6 studies	35% ± 22%	Explore
transit amplifying cell	6 studies	43% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	54% ± 23%	Explore
alveolar macrophage	5 studies	47% ± 10%	Explore
CD4-positive helper T cell	5 studies	32% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	46% ± 15%	Explore
hematopoietic precursor cell	5 studies	50% ± 29%	Explore
exhausted T cell	5 studies	74% ± 10%	Explore
ionocyte	5 studies	29% ± 11%	Explore
mononuclear phagocyte	5 studies	58% ± 21%	Explore
intestinal crypt stem cell	5 studies	34% ± 17%	Explore
precursor B cell	5 studies	43% ± 21%	Explore
pro-B cell	5 studies	40% ± 3%	Explore
T-helper 17 cell	5 studies	58% ± 23%	Explore
type II pneumocyte	5 studies	34% ± 20%	Explore
intermediate monocyte	5 studies	71% ± 15%	Explore
IgA plasma cell	5 studies	36% ± 23%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	61% ± 16%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	43% ± 17%	Explore
deuterosomal cell	4 studies	54% ± 14%	Explore
pancreatic A cell	4 studies	43% ± 23%	Explore
monocyte-derived dendritic cell	4 studies	59% ± 26%	Explore
glomerular endothelial cell	4 studies	39% ± 11%	Explore
renal alpha-intercalated cell	4 studies	35% ± 4%	Explore
hematopoietic stem cell	4 studies	42% ± 18%	Explore
immature B cell	4 studies	54% ± 8%	Explore
adventitial cell	4 studies	24% ± 4%	Explore
mucus secreting cell	4 studies	37% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	78% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	30% ± 6%	Explore
erythrocyte	4 studies	37% ± 12%	Explore
group 3 innate lymphoid cell	4 studies	54% ± 13%	Explore
T-helper 1 cell	4 studies	59% ± 18%	Explore
duct epithelial cell	3 studies	47% ± 13%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	23% ± 1%	Explore
extravillous trophoblast	3 studies	32% ± 13%	Explore
placental villous trophoblast	3 studies	55% ± 22%	Explore
common myeloid progenitor	3 studies	47% ± 19%	Explore
erythroblast	3 studies	40% ± 7%	Explore
lymphocyte	3 studies	55% ± 16%	Explore
neuroendocrine cell	3 studies	29% ± 6%	Explore
microglial cell	3 studies	31% ± 9%	Explore
serous secreting cell	3 studies	40% ± 6%	Explore
intraepithelial lymphocyte	3 studies	58% ± 3%	Explore
mesothelial cell	3 studies	32% ± 17%	Explore
neutrophil	3 studies	26% ± 6%	Explore
germinal center B cell	3 studies	36% ± 11%	Explore
neuron	3 studies	25% ± 12%	Explore
inflammatory macrophage	3 studies	26% ± 14%	Explore
enteroendocrine cell	3 studies	43% ± 12%	Explore
glial cell	3 studies	31% ± 12%	Explore
hepatocyte	3 studies	38% ± 21%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	51% ± 15%	Explore
double negative thymocyte	3 studies	65% ± 9%	Explore
progenitor cell of mammary luminal epithelium	3 studies	28% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	49% ± 13%	Explore
lung	18 studies	39% ± 13%	Explore
intestine	14 studies	33% ± 13%	Explore
kidney	8 studies	36% ± 14%	Explore
lymph node	7 studies	37% ± 10%	Explore
liver	6 studies	38% ± 10%	Explore
pancreas	5 studies	35% ± 18%	Explore
bone marrow	5 studies	30% ± 14%	Explore
placenta	5 studies	30% ± 16%	Explore
uterus	5 studies	40% ± 14%	Explore
prostate	4 studies	25% ± 7%	Explore
breast	4 studies	34% ± 8%	Explore
adrenal gland	3 studies	39% ± 10%	Explore
thymus	3 studies	55% ± 27%	Explore
brain	3 studies	30% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	5358.25	89 / 89	100%	80.81	901 / 901
liver	100%	5430.07	226 / 226	100%	127.60	406 / 406
pancreas	100%	2629.66	328 / 328	100%	120.17	178 / 178
uterus	100%	4315.03	170 / 170	100%	187.75	459 / 459
skin	100%	3255.04	1808 / 1809	100%	124.75	472 / 472
intestine	100%	4691.90	966 / 966	100%	146.96	526 / 527
prostate	100%	5032.71	245 / 245	100%	102.91	501 / 502
ovary	100%	3592.71	180 / 180	100%	101.41	429 / 430
lung	100%	5318.92	578 / 578	100%	120.74	1151 / 1155
stomach	100%	3618.62	359 / 359	100%	119.50	285 / 286
adrenal gland	100%	8675.29	258 / 258	100%	115.05	229 / 230
thymus	100%	4984.77	653 / 653	100%	105.57	602 / 605
bladder	100%	3641.10	21 / 21	99%	150.03	501 / 504
esophagus	100%	3385.65	1444 / 1445	99%	78.27	182 / 183
breast	100%	3902.06	459 / 459	99%	129.55	1108 / 1118
brain	99%	2074.79	2622 / 2642	99%	58.31	700 / 705
adipose	100%	3581.42	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	382.19	29 / 29
spleen	100%	9768.57	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	198.54	45 / 45
ureter	0%	0	0 / 0	100%	49.94	1 / 1
blood vessel	100%	3006.29	1330 / 1335	0%	0	0 / 0
heart	99%	2400.68	853 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	99%	83.56	79 / 80
peripheral blood	98%	6655.74	915 / 929	0%	0	0 / 0
muscle	97%	1648.83	776 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_2000045	Biological process	regulation of G1/S transition of mitotic cell cycle
GO_0010950	Biological process	positive regulation of endopeptidase activity
GO_0061136	Biological process	regulation of proteasomal protein catabolic process
GO_0000502	Cellular component	proteasome complex
GO_0070062	Cellular component	extracellular exosome
GO_0008537	Cellular component	proteasome activator complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0061133	Molecular function	endopeptidase activator activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PSME2
Protein name	Proteasome activator complex subunit 2 (11S regulator complex subunit beta) (REG-beta) (Activator of multicatalytic protease subunit 2) (Proteasome activator 28 subunit beta) (PA28b) (PA28beta) Proteasome activator complex subunit 2 (Proteasome activator 28 subunit beta) Proteasome activator subunit 2
Synonyms
Description	FUNCTION: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. FUNCTION: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. . FUNCTION: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. . FUNCTION: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. . FUNCTION: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. . FUNCTION: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. .
Accessions	ENST00000559056.5 H0YLD2 H0YLG1 ENST00000558273.5 ENST00000645325.2 Q86SZ7 H0YKU2 ENST00000560370.3 ENST00000216802.10 Q9UL46 ENST00000630027.1 Q6FHK9 ENST00000560410.5 ENST00000615264.4 H0YM70 A0A087X1Z3

PSME2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review