PDIA6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	38 studies	43% ± 18%	Explore
fibroblast	36 studies	45% ± 18%	Explore
macrophage	34 studies	36% ± 14%	Explore
natural killer cell	34 studies	35% ± 11%	Explore
B cell	33 studies	30% ± 12%	Explore
CD8-positive, alpha-beta T cell	27 studies	35% ± 18%	Explore
plasma cell	26 studies	64% ± 23%	Explore
pericyte	26 studies	39% ± 19%	Explore
conventional dendritic cell	26 studies	35% ± 14%	Explore
CD4-positive, alpha-beta T cell	26 studies	30% ± 17%	Explore
T cell	25 studies	31% ± 15%	Explore
smooth muscle cell	22 studies	36% ± 16%	Explore
epithelial cell	22 studies	47% ± 24%	Explore
classical monocyte	21 studies	29% ± 13%	Explore
non-classical monocyte	20 studies	31% ± 14%	Explore
basal cell	20 studies	47% ± 18%	Explore
mature NK T cell	19 studies	29% ± 8%	Explore
memory B cell	19 studies	26% ± 10%	Explore
plasmacytoid dendritic cell	19 studies	47% ± 13%	Explore
connective tissue cell	19 studies	52% ± 22%	Explore
regulatory T cell	19 studies	32% ± 12%	Explore
endothelial cell of lymphatic vessel	18 studies	45% ± 17%	Explore
naive B cell	18 studies	22% ± 7%	Explore
monocyte	16 studies	31% ± 11%	Explore
gamma-delta T cell	16 studies	33% ± 10%	Explore
mast cell	15 studies	33% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	34% ± 8%	Explore
ciliated cell	14 studies	43% ± 16%	Explore
myofibroblast cell	14 studies	46% ± 20%	Explore
dendritic cell	13 studies	36% ± 19%	Explore
plasmablast	12 studies	73% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	30% ± 11%	Explore
secretory cell	12 studies	45% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	35% ± 9%	Explore
capillary endothelial cell	12 studies	39% ± 17%	Explore
endothelial cell of artery	12 studies	40% ± 16%	Explore
vein endothelial cell	12 studies	40% ± 18%	Explore
mucosal invariant T cell	12 studies	30% ± 7%	Explore
endothelial cell of vascular tree	12 studies	34% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	31% ± 14%	Explore
myeloid cell	11 studies	38% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	25% ± 8%	Explore
mesothelial cell	10 studies	56% ± 20%	Explore
type II pneumocyte	9 studies	37% ± 20%	Explore
leukocyte	9 studies	31% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	19% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	28% ± 8%	Explore
progenitor cell	9 studies	59% ± 21%	Explore
abnormal cell	9 studies	45% ± 15%	Explore
IgA plasma cell	9 studies	56% ± 19%	Explore
IgG plasma cell	9 studies	54% ± 16%	Explore
type I pneumocyte	8 studies	34% ± 15%	Explore
club cell	8 studies	39% ± 15%	Explore
goblet cell	8 studies	40% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	43% ± 22%	Explore
astrocyte	7 studies	30% ± 12%	Explore
epithelial cell of proximal tubule	7 studies	34% ± 21%	Explore
precursor B cell	7 studies	42% ± 16%	Explore
T follicular helper cell	7 studies	25% ± 6%	Explore
alveolar macrophage	6 studies	30% ± 7%	Explore
hematopoietic precursor cell	6 studies	51% ± 18%	Explore
ionocyte	6 studies	31% ± 10%	Explore
respiratory goblet cell	6 studies	37% ± 20%	Explore
mononuclear phagocyte	6 studies	38% ± 20%	Explore
kidney loop of Henle epithelial cell	6 studies	35% ± 14%	Explore
renal alpha-intercalated cell	6 studies	49% ± 14%	Explore
innate lymphoid cell	6 studies	31% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	35% ± 19%	Explore
transit amplifying cell	5 studies	41% ± 14%	Explore
hematopoietic stem cell	5 studies	38% ± 14%	Explore
pro-B cell	5 studies	44% ± 10%	Explore
mucus secreting cell	5 studies	32% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	42% ± 17%	Explore
neuron	5 studies	38% ± 13%	Explore
oligodendrocyte precursor cell	5 studies	38% ± 15%	Explore
erythrocyte	5 studies	28% ± 15%	Explore
pancreatic A cell	4 studies	45% ± 15%	Explore
type B pancreatic cell	4 studies	51% ± 23%	Explore
exhausted T cell	4 studies	45% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	64% ± 21%	Explore
enterocyte	4 studies	38% ± 14%	Explore
enteroendocrine cell	4 studies	58% ± 15%	Explore
intestinal crypt stem cell	4 studies	36% ± 15%	Explore
glial cell	4 studies	40% ± 26%	Explore
erythroblast	4 studies	41% ± 17%	Explore
brush cell	4 studies	24% ± 9%	Explore
immature B cell	4 studies	27% ± 9%	Explore
microglial cell	4 studies	34% ± 12%	Explore
adventitial cell	4 studies	52% ± 10%	Explore
muscle cell	4 studies	31% ± 19%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	41% ± 7%	Explore
luminal cell of prostate epithelium	4 studies	29% ± 10%	Explore
IgM plasma cell	4 studies	47% ± 19%	Explore
GABAergic neuron	4 studies	33% ± 10%	Explore
glutamatergic neuron	4 studies	49% ± 16%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	56% ± 23%	Explore
T-helper 17 cell	4 studies	41% ± 27%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	29% ± 5%	Explore
duct epithelial cell	3 studies	49% ± 2%	Explore
precursor cell	3 studies	66% ± 9%	Explore
glomerular endothelial cell	3 studies	30% ± 6%	Explore
podocyte	3 studies	68% ± 21%	Explore
neural crest cell	3 studies	62% ± 8%	Explore
retinal bipolar neuron	3 studies	28% ± 10%	Explore
renal principal cell	3 studies	53% ± 11%	Explore
extravillous trophoblast	3 studies	95% ± 1%	Explore
placental villous trophoblast	3 studies	88% ± 7%	Explore
common myeloid progenitor	3 studies	48% ± 14%	Explore
lymphocyte	3 studies	48% ± 10%	Explore
retinal cone cell	3 studies	32% ± 11%	Explore
serous secreting cell	3 studies	47% ± 5%	Explore
tissue-resident macrophage	3 studies	39% ± 16%	Explore
intraepithelial lymphocyte	3 studies	33% ± 7%	Explore
Mueller cell	3 studies	25% ± 2%	Explore
acinar cell	3 studies	38% ± 12%	Explore
germinal center B cell	3 studies	35% ± 4%	Explore
intermediate monocyte	3 studies	41% ± 15%	Explore
CD4-positive helper T cell	3 studies	24% ± 8%	Explore
myoepithelial cell	3 studies	46% ± 21%	Explore
granulocyte monocyte progenitor cell	3 studies	74% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	43% ± 16%	Explore
interneuron	3 studies	24% ± 3%	Explore
oligodendrocyte	3 studies	24% ± 4%	Explore
T-helper 1 cell	3 studies	42% ± 21%	Explore
double negative thymocyte	3 studies	41% ± 13%	Explore
progenitor cell of mammary luminal epithelium	3 studies	35% ± 6%	Explore
hepatocyte	3 studies	55% ± 22%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	39% ± 16%	Explore
peripheral blood	16 studies	29% ± 11%	Explore
intestine	11 studies	41% ± 18%	Explore
kidney	9 studies	36% ± 14%	Explore
brain	8 studies	32% ± 13%	Explore
eye	7 studies	23% ± 9%	Explore
bone marrow	6 studies	33% ± 13%	Explore
liver	6 studies	34% ± 14%	Explore
pancreas	5 studies	42% ± 20%	Explore
lymph node	5 studies	35% ± 15%	Explore
placenta	4 studies	63% ± 29%	Explore
uterus	4 studies	52% ± 19%	Explore
prostate	4 studies	34% ± 10%	Explore
breast	4 studies	35% ± 3%	Explore
adrenal gland	3 studies	36% ± 8%	Explore
skin	3 studies	27% ± 8%	Explore
thymus	3 studies	42% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	100%	5343.97	359 / 359	99%	157.23	284 / 286
esophagus	100%	4111.87	1442 / 1445	99%	116.77	182 / 183
lung	100%	6652.93	577 / 578	99%	202.45	1147 / 1155
pancreas	100%	7876.18	328 / 328	99%	117.66	176 / 178
intestine	100%	5052.04	965 / 966	99%	173.52	520 / 527
ovary	100%	5000.62	180 / 180	98%	145.70	423 / 430
breast	100%	5025.78	459 / 459	98%	149.55	1098 / 1118
prostate	100%	3613.89	244 / 245	97%	148.00	487 / 502
skin	100%	9546.81	1805 / 1809	96%	175.11	455 / 472
uterus	100%	5251.32	170 / 170	96%	164.57	441 / 459
bladder	100%	5071.29	21 / 21	95%	156.55	480 / 504
thymus	100%	10016.23	653 / 653	95%	151.07	572 / 605
kidney	100%	5239.74	89 / 89	89%	112.45	804 / 901
liver	95%	6246.46	214 / 226	94%	119.91	383 / 406
brain	86%	1843.05	2280 / 2642	98%	89.31	689 / 705
adrenal gland	100%	6243.79	258 / 258	73%	55.04	169 / 230
adipose	100%	5689.57	1204 / 1204	0%	0	0 / 0
spleen	100%	6005.26	241 / 241	0%	0	0 / 0
blood vessel	100%	5568.31	1330 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	124.65	44 / 45
muscle	97%	2172.15	780 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	123.20	27 / 29
heart	92%	4230.84	796 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	90%	68.34	72 / 80
peripheral blood	87%	4674.72	810 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006457	Biological process	protein folding
GO_0034976	Biological process	response to endoplasmic reticulum stress
GO_0042470	Cellular component	melanosome
GO_0005615	Cellular component	extracellular space
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0034663	Cellular component	endoplasmic reticulum chaperone complex
GO_0070062	Cellular component	extracellular exosome
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005793	Cellular component	endoplasmic reticulum-Golgi intermediate compartment
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0015035	Molecular function	protein-disulfide reductase activity
GO_0003756	Molecular function	protein disulfide isomerase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PDIA6
Protein name	Protein disulfide isomerase family A member 6 Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)
Synonyms	P5 ERP5 TXNDC7
Description	FUNCTION: May function as a chaperone that inhibits aggregation of misfolded proteins . Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling . May also regulate the UPR via the EIF2AK3 UPR sensor . Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin . .
Accessions	ENST00000272227.8 [Q15084-1] ENST00000540494.5 [Q15084-3] ENST00000404371.6 [Q15084-2] ENST00000381611.8 [Q15084-4] ENST00000617249.4 [Q15084-2] ENST00000404824.2 [Q15084-5] ENST00000458536.1 C9JNG5 Q15084

PDIA6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review