PDCD6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0097190Biological processapoptotic signaling pathway
GO_0034605Biological processcellular response to heat
GO_0045766Biological processpositive regulation of angiogenesis
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0032007Biological processnegative regulation of TOR signaling
GO_1902527Biological processpositive regulation of protein monoubiquitination
GO_0006886Biological processintracellular protein transport
GO_0030948Biological processnegative regulation of vascular endothelial growth factor receptor signaling pathway
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0014032Biological processneural crest cell development
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0014029Biological processneural crest formation
GO_0036324Biological processvascular endothelial growth factor receptor-2 signaling pathway
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0051592Biological processresponse to calcium ion
GO_0048208Biological processCOPII vesicle coating
GO_0031410Cellular componentcytoplasmic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0030127Cellular componentCOPII vesicle coat
GO_0070971Cellular componentendoplasmic reticulum exit site
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005768Cellular componentendosome
GO_0005634Cellular componentnucleus
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0043495Molecular functionprotein-membrane adaptor activity
GO_0042802Molecular functionidentical protein binding
GO_0000287Molecular functionmagnesium ion binding
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005509Molecular functioncalcium ion binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePDCD6
Protein nameHCG1985580, isoform CRA_c (Programmed cell death 6)
Programmed cell death 6
PDCD6 protein (Programmed cell death 6)
Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2)
SynonymsALG2
hCG_1985580
DescriptionFUNCTION: Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes . Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes . Together with PEF1, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats . In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification . Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway . Promotes localization and polymerization of TFG at endoplasmic reticulum exit site . Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity . Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway . In case of infection by HIV-1 virus, indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution . .; FUNCTION: [Isoform 2]: Has a lower Ca(2+) affinity than isoform 1 (By similarity). .

AccessionsA0A024QZ42
ENST00000264933.9 [O75340-1]
O75340
ENST00000509581.5
A0A087WZ38
ENST00000618970.4
D6RA21
ENST00000505526.1
ENST00000505221.5 [O75340-3]
H0Y9X3
ENST00000507473.1
ENST00000507528.5 [O75340-2]
Q86W51
ENST00000614778.4