PAIP2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	37 studies	32% ± 13%	Explore
B cell	36 studies	35% ± 12%	Explore
natural killer cell	36 studies	39% ± 11%	Explore
fibroblast	34 studies	29% ± 12%	Explore
macrophage	32 studies	28% ± 10%	Explore
CD8-positive, alpha-beta T cell	31 studies	37% ± 10%	Explore
CD4-positive, alpha-beta T cell	30 studies	35% ± 11%	Explore
T cell	28 studies	33% ± 10%	Explore
conventional dendritic cell	27 studies	33% ± 15%	Explore
regulatory T cell	26 studies	39% ± 11%	Explore
pericyte	25 studies	34% ± 12%	Explore
smooth muscle cell	23 studies	31% ± 9%	Explore
non-classical monocyte	23 studies	41% ± 15%	Explore
classical monocyte	23 studies	34% ± 13%	Explore
monocyte	20 studies	30% ± 9%	Explore
plasmacytoid dendritic cell	20 studies	40% ± 13%	Explore
memory B cell	19 studies	31% ± 7%	Explore
naive B cell	19 studies	34% ± 8%	Explore
mature NK T cell	18 studies	38% ± 9%	Explore
endothelial cell of lymphatic vessel	17 studies	32% ± 11%	Explore
ciliated cell	17 studies	44% ± 19%	Explore
gamma-delta T cell	17 studies	41% ± 15%	Explore
dendritic cell	16 studies	33% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	35% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	36% ± 13%	Explore
epithelial cell	15 studies	36% ± 20%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	41% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	42% ± 11%	Explore
basal cell	14 studies	32% ± 14%	Explore
connective tissue cell	14 studies	36% ± 11%	Explore
mucosal invariant T cell	13 studies	36% ± 10%	Explore
mast cell	12 studies	26% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	36% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	41% ± 12%	Explore
capillary endothelial cell	12 studies	30% ± 8%	Explore
vein endothelial cell	12 studies	27% ± 8%	Explore
endothelial cell of vascular tree	12 studies	29% ± 7%	Explore
plasma cell	11 studies	33% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	41% ± 15%	Explore
myofibroblast cell	11 studies	36% ± 9%	Explore
myeloid cell	11 studies	29% ± 11%	Explore
platelet	10 studies	35% ± 10%	Explore
endothelial cell of artery	10 studies	30% ± 5%	Explore
oligodendrocyte	10 studies	26% ± 10%	Explore
leukocyte	9 studies	32% ± 12%	Explore
abnormal cell	9 studies	35% ± 9%	Explore
microglial cell	9 studies	23% ± 8%	Explore
astrocyte	9 studies	31% ± 13%	Explore
plasmablast	8 studies	41% ± 22%	Explore
neuron	8 studies	43% ± 19%	Explore
mesothelial cell	8 studies	31% ± 20%	Explore
hematopoietic stem cell	8 studies	49% ± 9%	Explore
secretory cell	8 studies	28% ± 13%	Explore
GABAergic neuron	8 studies	35% ± 17%	Explore
type I pneumocyte	7 studies	23% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	37% ± 8%	Explore
epithelial cell of proximal tubule	7 studies	26% ± 6%	Explore
progenitor cell	7 studies	27% ± 11%	Explore
precursor B cell	7 studies	54% ± 16%	Explore
immature B cell	7 studies	47% ± 15%	Explore
T follicular helper cell	7 studies	35% ± 6%	Explore
alveolar macrophage	6 studies	25% ± 6%	Explore
neutrophil	6 studies	21% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	41% ± 7%	Explore
kidney loop of Henle epithelial cell	6 studies	27% ± 8%	Explore
glutamatergic neuron	6 studies	43% ± 23%	Explore
retinal cone cell	6 studies	50% ± 29%	Explore
innate lymphoid cell	6 studies	38% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	40% ± 13%	Explore
oligodendrocyte precursor cell	6 studies	35% ± 11%	Explore
erythrocyte	6 studies	32% ± 19%	Explore
CD4-positive helper T cell	5 studies	30% ± 14%	Explore
hematopoietic precursor cell	5 studies	55% ± 24%	Explore
exhausted T cell	5 studies	44% ± 9%	Explore
mononuclear phagocyte	5 studies	37% ± 15%	Explore
retinal rod cell	5 studies	36% ± 16%	Explore
lymphocyte	5 studies	32% ± 13%	Explore
pro-B cell	5 studies	60% ± 9%	Explore
club cell	5 studies	26% ± 6%	Explore
granulocyte	5 studies	30% ± 8%	Explore
interneuron	5 studies	37% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	28% ± 11%	Explore
pancreatic A cell	4 studies	49% ± 11%	Explore
type B pancreatic cell	4 studies	54% ± 20%	Explore
OFF-bipolar cell	4 studies	47% ± 29%	Explore
ON-bipolar cell	4 studies	48% ± 29%	Explore
retinal ganglion cell	4 studies	76% ± 27%	Explore
erythroblast	4 studies	40% ± 19%	Explore
type II pneumocyte	4 studies	29% ± 15%	Explore
amacrine cell	4 studies	58% ± 23%	Explore
retina horizontal cell	4 studies	53% ± 17%	Explore
muscle cell	4 studies	28% ± 15%	Explore
intermediate monocyte	4 studies	44% ± 23%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	32% ± 2%	Explore
luminal cell of prostate epithelium	4 studies	29% ± 11%	Explore
goblet cell	4 studies	31% ± 13%	Explore
T-helper 17 cell	4 studies	35% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	35% ± 7%	Explore
double negative thymocyte	4 studies	52% ± 19%	Explore
deuterosomal cell	3 studies	19% ± 1%	Explore
squamous epithelial cell	3 studies	35% ± 24%	Explore
pancreatic D cell	3 studies	49% ± 20%	Explore
glomerular endothelial cell	3 studies	31% ± 6%	Explore
podocyte	3 studies	49% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	40% ± 8%	Explore
renal alpha-intercalated cell	3 studies	37% ± 8%	Explore
neural crest cell	3 studies	40% ± 7%	Explore
IgA plasma cell	3 studies	18% ± 3%	Explore
retinal bipolar neuron	3 studies	57% ± 25%	Explore
GABAergic amacrine cell	3 studies	41% ± 14%	Explore
glycinergic amacrine cell	3 studies	35% ± 12%	Explore
placental villous trophoblast	3 studies	44% ± 16%	Explore
megakaryocyte	3 studies	48% ± 13%	Explore
retinal pigment epithelial cell	3 studies	35% ± 19%	Explore
intraepithelial lymphocyte	3 studies	40% ± 20%	Explore
Mueller cell	3 studies	46% ± 8%	Explore
rod bipolar cell	3 studies	50% ± 15%	Explore
cardiac muscle cell	3 studies	21% ± 2%	Explore
germinal center B cell	3 studies	40% ± 6%	Explore
myoepithelial cell	3 studies	27% ± 6%	Explore
pancreatic ductal cell	3 studies	47% ± 16%	Explore
enteroendocrine cell	3 studies	39% ± 19%	Explore
glial cell	3 studies	40% ± 24%	Explore
group 3 innate lymphoid cell	3 studies	45% ± 14%	Explore
melanocyte	3 studies	20% ± 2%	Explore
keratinocyte	3 studies	26% ± 8%	Explore
T-helper 1 cell	3 studies	45% ± 2%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	37% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	38% ± 14%	Explore
lung	17 studies	32% ± 13%	Explore
brain	13 studies	31% ± 15%	Explore
eye	10 studies	35% ± 17%	Explore
intestine	9 studies	28% ± 13%	Explore
kidney	9 studies	30% ± 8%	Explore
placenta	5 studies	26% ± 9%	Explore
lymph node	5 studies	38% ± 4%	Explore
liver	5 studies	37% ± 19%	Explore
pancreas	4 studies	48% ± 16%	Explore
bone marrow	4 studies	31% ± 9%	Explore
uterus	4 studies	38% ± 13%	Explore
prostate	4 studies	25% ± 7%	Explore
breast	4 studies	28% ± 4%	Explore
adrenal gland	3 studies	33% ± 8%	Explore
skin	3 studies	26% ± 3%	Explore
thymus	3 studies	56% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	2763.53	459 / 459	100%	51.63	1118 / 1118
esophagus	100%	2375.41	1444 / 1445	100%	25.53	183 / 183
brain	100%	3661.16	2638 / 2642	100%	61.29	705 / 705
ovary	100%	2962.10	180 / 180	100%	41.65	429 / 430
stomach	100%	1779.16	359 / 359	100%	30.01	285 / 286
lung	100%	2196.73	576 / 578	100%	33.94	1153 / 1155
bladder	100%	2269.14	21 / 21	99%	32.25	501 / 504
prostate	100%	2087.82	244 / 245	100%	49.43	501 / 502
intestine	100%	2329.63	966 / 966	99%	31.15	523 / 527
thymus	100%	2181.15	652 / 653	99%	39.64	601 / 605
uterus	100%	2529.39	170 / 170	99%	35.76	455 / 459
kidney	100%	2276.47	89 / 89	99%	41.82	891 / 901
skin	100%	1909.11	1805 / 1809	98%	39.27	464 / 472
adrenal gland	100%	4038.10	258 / 258	98%	62.15	225 / 230
liver	96%	1111.12	218 / 226	100%	28.05	404 / 406
pancreas	96%	984.49	314 / 328	99%	28.35	176 / 178
adipose	100%	2905.50	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2837.41	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	47.76	29 / 29
muscle	100%	3278.61	803 / 803	0%	0	0 / 0
spleen	100%	2181.19	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	35.71	45 / 45
ureter	0%	0	0 / 0	100%	10.17	1 / 1
peripheral blood	98%	2374.74	911 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	95%	36.65	76 / 80
heart	94%	2521.30	811 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	PAIP2
Protein name	Poly(A) binding protein interacting protein 2 Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2) Polyadenylate-binding protein-interacting protein 2
Synonyms	PAIP2A HSPC218
Description	FUNCTION: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. . FUNCTION: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. . FUNCTION: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. . FUNCTION: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. .
Accessions	ENST00000394795.6 Q49AE6 Q9BPZ3 D6RA77 Q6FID7 ENST00000507755.5 ENST00000265192.9 ENST00000511706.5 ENST00000510080.1 D6R9Y1

GO_0007613	Biological process	memory
GO_0006412	Biological process	translation
GO_0007283	Biological process	spermatogenesis
GO_1900271	Biological process	regulation of long-term synaptic potentiation
GO_0045947	Biological process	negative regulation of translational initiation
GO_0017148	Biological process	negative regulation of translation
GO_0005737	Cellular component	cytoplasm
GO_0030371	Molecular function	translation repressor activity
GO_0000900	Molecular function	mRNA regulatory element binding translation repressor activity
GO_0005515	Molecular function	protein binding
GO_0003729	Molecular function	mRNA binding

PAIP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review