PAFAH1B1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007254Biological processJNK cascade
GO_0001961Biological processpositive regulation of cytokine-mediated signaling pathway
GO_0050885Biological processneuromuscular process controlling balance
GO_0021819Biological processlayer formation in cerebral cortex
GO_0001764Biological processneuron migration
GO_0140650Biological processradial glia-guided pyramidal neuron migration
GO_0090176Biological processmicrotubule cytoskeleton organization involved in establishment of planar polarity
GO_0045931Biological processpositive regulation of mitotic cell cycle
GO_0030036Biological processactin cytoskeleton organization
GO_0090102Biological processcochlea development
GO_0046329Biological processnegative regulation of JNK cascade
GO_0001667Biological processameboidal-type cell migration
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0031023Biological processmicrotubule organizing center organization
GO_0051660Biological processestablishment of centrosome localization
GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0051661Biological processmaintenance of centrosome location
GO_0040019Biological processpositive regulation of embryonic development
GO_0007281Biological processgerm cell development
GO_0038026Biological processreelin-mediated signaling pathway
GO_0042249Biological processestablishment of planar polarity of embryonic epithelium
GO_0060117Biological processauditory receptor cell development
GO_0051081Biological processnuclear membrane disassembly
GO_0046469Biological processplatelet activating factor metabolic process
GO_0070507Biological processregulation of microtubule cytoskeleton organization
GO_0097529Biological processmyeloid leukocyte migration
GO_0021540Biological processcorpus callosum morphogenesis
GO_0047496Biological processvesicle transport along microtubule
GO_0007405Biological processneuroblast proliferation
GO_0021766Biological processhippocampus development
GO_0008090Biological processretrograde axonal transport
GO_0043622Biological processcortical microtubule organization
GO_0016042Biological processlipid catabolic process
GO_0010977Biological processnegative regulation of neuron projection development
GO_0007268Biological processchemical synaptic transmission
GO_1904936Biological processinterneuron migration
GO_0007097Biological processnuclear migration
GO_0021895Biological processcerebral cortex neuron differentiation
GO_0036035Biological processosteoclast development
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0045773Biological processpositive regulation of axon extension
GO_0061003Biological processpositive regulation of dendritic spine morphogenesis
GO_0007611Biological processlearning or memory
GO_0007017Biological processmicrotubule-based process
GO_0008344Biological processadult locomotory behavior
GO_0017145Biological processstem cell division
GO_0051012Biological processmicrotubule sliding
GO_0001675Biological processacrosome assembly
GO_0048854Biological processbrain morphogenesis
GO_0019226Biological processtransmission of nerve impulse
GO_0021987Biological processcerebral cortex development
GO_0009306Biological processprotein secretion
GO_0098978Cellular componentglutamatergic synapse
GO_0000235Cellular componentastral microtubule
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0043025Cellular componentneuronal cell body
GO_0043005Cellular componentneuron projection
GO_0005881Cellular componentcytoplasmic microtubule
GO_0032420Cellular componentstereocilium
GO_0070062Cellular componentextracellular exosome
GO_0005813Cellular componentcentrosome
GO_0031514Cellular componentmotile cilium
GO_0031252Cellular componentcell leading edge
GO_0008247Cellular component1-alkyl-2-acetylglycerophosphocholine esterase complex
GO_1904115Cellular componentaxon cytoplasm
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0000776Cellular componentkinetochore
GO_0005871Cellular componentkinesin complex
GO_0005635Cellular componentnuclear envelope
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0090724Cellular componentcentral region of growth cone
GO_0031965Cellular componentnuclear membrane
GO_0005875Cellular componentmicrotubule associated complex
GO_0034452Molecular functiondynactin binding
GO_0042802Molecular functionidentical protein binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0043274Molecular functionphospholipase binding
GO_0008201Molecular functionheparin binding
GO_0045505Molecular functiondynein intermediate chain binding
GO_0005515Molecular functionprotein binding
GO_0051010Molecular functionmicrotubule plus-end binding
GO_0008017Molecular functionmicrotubule binding
GO_0070840Molecular functiondynein complex binding
GO_0051219Molecular functionphosphoprotein binding

IV. Literature review

[source]
Gene namePAFAH1B1
Protein namePlatelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)
Platelet activating factor acetylhydrolase 1b regulatory subunit 1
Platelet-activating factor acetylhydrolase IB subunit alpha (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)
SynonymsPAFAHA
MDCR
MDS
LIS1
DescriptionFUNCTION: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos . May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity). .

FUNCTION: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position. .

AccessionsENST00000676077.1
ENST00000576586.5
ENST00000675202.1 [P43034-1]
ENST00000675621.1
ENST00000676188.1 [P43034-1]
A0A6Q8PH33
ENST00000676353.1
ENST00000574468.1
I3L384
A0A6Q8PG63
ENST00000570400.1
ENST00000397195.10 [P43034-1]
ENST00000674608.1
ENST00000675764.1
ENST00000675390.1 [P43034-1]
I3L495
P43034
ENST00000674717.1
ENST00000675331.1 [P43034-1]
A0A6Q8PGF8
ENST00000676098.1 [P43034-1]
I3L3N5
A0A6Q8PFT2
A0A6Q8PFU3