MLF2 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
fibroblast	27 studies	31% ± 13%	Explore
endothelial cell	24 studies	28% ± 11%	Explore
smooth muscle cell	22 studies	33% ± 13%	Explore
pericyte	22 studies	31% ± 10%	Explore
natural killer cell	21 studies	24% ± 7%	Explore
conventional dendritic cell	21 studies	29% ± 14%	Explore
CD8-positive, alpha-beta T cell	20 studies	25% ± 7%	Explore
B cell	19 studies	25% ± 7%	Explore
basal cell	18 studies	37% ± 19%	Explore
epithelial cell	18 studies	37% ± 23%	Explore
macrophage	18 studies	23% ± 6%	Explore
plasmacytoid dendritic cell	17 studies	42% ± 13%	Explore
CD4-positive, alpha-beta T cell	17 studies	24% ± 8%	Explore
memory B cell	16 studies	24% ± 6%	Explore
regulatory T cell	16 studies	23% ± 5%	Explore
classical monocyte	15 studies	27% ± 10%	Explore
connective tissue cell	14 studies	35% ± 16%	Explore
naive B cell	14 studies	24% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	27% ± 5%	Explore
monocyte	12 studies	24% ± 6%	Explore
non-classical monocyte	12 studies	28% ± 11%	Explore
myofibroblast cell	12 studies	40% ± 14%	Explore
gamma-delta T cell	12 studies	28% ± 12%	Explore
T cell	11 studies	25% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	24% ± 8%	Explore
endothelial cell of lymphatic vessel	10 studies	28% ± 9%	Explore
ciliated cell	10 studies	32% ± 14%	Explore
secretory cell	10 studies	27% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	25% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	20% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	24% ± 4%	Explore
abnormal cell	10 studies	39% ± 17%	Explore
endothelial cell of vascular tree	10 studies	24% ± 5%	Explore
mucosal invariant T cell	9 studies	23% ± 3%	Explore
mast cell	8 studies	23% ± 6%	Explore
plasma cell	8 studies	35% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	24% ± 5%	Explore
mature NK T cell	8 studies	24% ± 3%	Explore
neuron	8 studies	44% ± 24%	Explore
endothelial cell of artery	8 studies	21% ± 4%	Explore
goblet cell	8 studies	27% ± 11%	Explore
glutamatergic neuron	8 studies	34% ± 19%	Explore
dendritic cell	8 studies	40% ± 19%	Explore
type I pneumocyte	7 studies	32% ± 17%	Explore
club cell	7 studies	33% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	25% ± 6%	Explore
vein endothelial cell	7 studies	24% ± 8%	Explore
myeloid cell	7 studies	25% ± 9%	Explore
capillary endothelial cell	7 studies	23% ± 9%	Explore
hematopoietic precursor cell	6 studies	37% ± 17%	Explore
plasmablast	6 studies	40% ± 20%	Explore
respiratory goblet cell	6 studies	31% ± 20%	Explore
epithelial cell of proximal tubule	6 studies	31% ± 11%	Explore
progenitor cell	6 studies	35% ± 15%	Explore
enterocyte	6 studies	25% ± 6%	Explore
transit amplifying cell	6 studies	21% ± 6%	Explore
hematopoietic stem cell	6 studies	38% ± 9%	Explore
precursor B cell	6 studies	32% ± 10%	Explore
kidney loop of Henle epithelial cell	5 studies	31% ± 9%	Explore
enteroendocrine cell	5 studies	35% ± 15%	Explore
mesothelial cell	5 studies	47% ± 17%	Explore
amacrine cell	5 studies	39% ± 21%	Explore
pro-B cell	5 studies	31% ± 6%	Explore
type II pneumocyte	5 studies	41% ± 18%	Explore
astrocyte	5 studies	25% ± 14%	Explore
T follicular helper cell	5 studies	22% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	26% ± 4%	Explore
GABAergic neuron	5 studies	35% ± 12%	Explore
exhausted T cell	4 studies	30% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	49% ± 6%	Explore
intestinal crypt stem cell	4 studies	24% ± 6%	Explore
retinal ganglion cell	4 studies	68% ± 25%	Explore
innate lymphoid cell	4 studies	21% ± 4%	Explore
immature B cell	4 studies	26% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	26% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	41% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	26% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	21% ± 4%	Explore
precursor cell	3 studies	52% ± 12%	Explore
squamous epithelial cell	3 studies	37% ± 26%	Explore
pancreatic A cell	3 studies	52% ± 14%	Explore
renal alpha-intercalated cell	3 studies	37% ± 4%	Explore
leukocyte	3 studies	24% ± 6%	Explore
neural crest cell	3 studies	38% ± 4%	Explore
retinal bipolar neuron	3 studies	42% ± 14%	Explore
placental villous trophoblast	3 studies	53% ± 10%	Explore
erythroblast	3 studies	32% ± 12%	Explore
lymphocyte	3 studies	24% ± 5%	Explore
brush cell	3 studies	30% ± 10%	Explore
neuroendocrine cell	3 studies	43% ± 15%	Explore
retina horizontal cell	3 studies	40% ± 15%	Explore
retinal cone cell	3 studies	49% ± 21%	Explore
retinal rod cell	3 studies	28% ± 12%	Explore
alveolar macrophage	3 studies	21% ± 4%	Explore
serous secreting cell	3 studies	31% ± 4%	Explore
Mueller cell	3 studies	28% ± 6%	Explore
germinal center B cell	3 studies	27% ± 6%	Explore
intermediate monocyte	3 studies	36% ± 18%	Explore
oligodendrocyte precursor cell	3 studies	44% ± 17%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	40% ± 31%	Explore
group 3 innate lymphoid cell	3 studies	29% ± 9%	Explore
keratinocyte	3 studies	24% ± 5%	Explore
interneuron	3 studies	36% ± 11%	Explore
oligodendrocyte	3 studies	21% ± 2%	Explore
T-helper 1 cell	3 studies	26% ± 9%	Explore
double negative thymocyte	3 studies	37% ± 16%	Explore
progenitor cell of mammary luminal epithelium	3 studies	33% ± 11%	Explore
hepatocyte	3 studies	42% ± 25%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
lung	14 studies	31% ± 14%	Explore
peripheral blood	13 studies	26% ± 6%	Explore
brain	9 studies	28% ± 13%	Explore
intestine	8 studies	30% ± 14%	Explore
kidney	7 studies	26% ± 5%	Explore
eye	7 studies	27% ± 13%	Explore
lymph node	5 studies	28% ± 11%	Explore
placenta	4 studies	33% ± 12%	Explore
bone marrow	4 studies	21% ± 3%	Explore
uterus	4 studies	31% ± 15%	Explore
breast	4 studies	27% ± 5%	Explore
pancreas	3 studies	46% ± 19%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	12627.89	258 / 258	100%	245.48	230 / 230
esophagus	100%	10648.74	1445 / 1445	100%	188.71	183 / 183
intestine	100%	10147.29	966 / 966	100%	211.13	527 / 527
liver	100%	10698.97	226 / 226	100%	182.84	406 / 406
ovary	100%	8287.51	180 / 180	100%	311.34	430 / 430
pancreas	100%	4285.17	328 / 328	100%	175.57	178 / 178
skin	100%	10316.16	1809 / 1809	100%	223.34	472 / 472
thymus	100%	9127.46	653 / 653	100%	225.98	605 / 605
uterus	100%	10632.76	170 / 170	100%	256.03	459 / 459
brain	100%	14814.15	2641 / 2642	100%	323.26	705 / 705
prostate	100%	10913.43	245 / 245	100%	275.08	500 / 502
kidney	100%	9937.79	89 / 89	99%	178.06	895 / 901
stomach	100%	7669.67	359 / 359	99%	193.31	284 / 286
breast	100%	8341.35	459 / 459	99%	239.96	1107 / 1118
bladder	100%	9752.86	21 / 21	99%	239.37	499 / 504
lung	100%	8186.89	576 / 578	98%	230.74	1135 / 1155
adipose	100%	8207.32	1204 / 1204	0%	0	0 / 0
blood vessel	100%	9620.11	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	173.63	80 / 80
lymph node	0%	0	0 / 0	100%	149.39	29 / 29
muscle	100%	7407.70	803 / 803	0%	0	0 / 0
spleen	100%	7340.04	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	227.58	45 / 45
ureter	0%	0	0 / 0	100%	143.09	1 / 1
peripheral blood	99%	8961.49	917 / 929	0%	0	0 / 0
heart	98%	7087.09	846 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0