MICOS13 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD8-positive, alpha-beta T cell	27 studies	27% ± 10%	Explore
natural killer cell	26 studies	23% ± 6%	Explore
fibroblast	26 studies	29% ± 12%	Explore
macrophage	25 studies	32% ± 12%	Explore
CD4-positive, alpha-beta T cell	25 studies	26% ± 8%	Explore
pericyte	24 studies	30% ± 9%	Explore
conventional dendritic cell	23 studies	30% ± 13%	Explore
endothelial cell	23 studies	29% ± 12%	Explore
smooth muscle cell	22 studies	30% ± 10%	Explore
T cell	20 studies	22% ± 6%	Explore
non-classical monocyte	18 studies	32% ± 13%	Explore
B cell	17 studies	25% ± 7%	Explore
regulatory T cell	17 studies	27% ± 9%	Explore
basal cell	16 studies	34% ± 16%	Explore
endothelial cell of lymphatic vessel	15 studies	33% ± 8%	Explore
ciliated cell	15 studies	59% ± 19%	Explore
epithelial cell	15 studies	39% ± 23%	Explore
classical monocyte	15 studies	29% ± 11%	Explore
monocyte	14 studies	25% ± 9%	Explore
memory B cell	13 studies	24% ± 9%	Explore
myofibroblast cell	13 studies	26% ± 6%	Explore
connective tissue cell	13 studies	30% ± 8%	Explore
naive B cell	12 studies	22% ± 4%	Explore
mature NK T cell	12 studies	26% ± 7%	Explore
mast cell	11 studies	21% ± 3%	Explore
plasma cell	11 studies	35% ± 13%	Explore
dendritic cell	11 studies	39% ± 24%	Explore
plasmacytoid dendritic cell	11 studies	29% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	27% ± 7%	Explore
gamma-delta T cell	11 studies	28% ± 11%	Explore
endothelial cell of artery	10 studies	21% ± 6%	Explore
vein endothelial cell	10 studies	22% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	27% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	26% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	34% ± 10%	Explore
secretory cell	8 studies	32% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	29% ± 6%	Explore
capillary endothelial cell	8 studies	21% ± 4%	Explore
progenitor cell	8 studies	34% ± 16%	Explore
mucosal invariant T cell	8 studies	26% ± 6%	Explore
myeloid cell	8 studies	29% ± 12%	Explore
endothelial cell of vascular tree	8 studies	26% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	30% ± 9%	Explore
club cell	7 studies	30% ± 7%	Explore
goblet cell	7 studies	30% ± 13%	Explore
type I pneumocyte	6 studies	35% ± 10%	Explore
respiratory goblet cell	6 studies	29% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	33% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	29% ± 10%	Explore
epithelial cell of proximal tubule	6 studies	39% ± 9%	Explore
kidney loop of Henle epithelial cell	6 studies	44% ± 12%	Explore
renal alpha-intercalated cell	6 studies	53% ± 16%	Explore
transit amplifying cell	6 studies	30% ± 9%	Explore
abnormal cell	6 studies	40% ± 16%	Explore
alveolar macrophage	5 studies	40% ± 11%	Explore
leukocyte	5 studies	24% ± 6%	Explore
mononuclear phagocyte	5 studies	33% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	39% ± 16%	Explore
neuron	5 studies	34% ± 13%	Explore
enterocyte	5 studies	33% ± 10%	Explore
type II pneumocyte	5 studies	40% ± 18%	Explore
astrocyte	5 studies	27% ± 13%	Explore
T follicular helper cell	5 studies	22% ± 3%	Explore
hematopoietic precursor cell	4 studies	40% ± 11%	Explore
ionocyte	4 studies	34% ± 11%	Explore
exhausted T cell	4 studies	35% ± 10%	Explore
intestinal crypt stem cell	4 studies	29% ± 12%	Explore
retinal ganglion cell	4 studies	79% ± 21%	Explore
brush cell	4 studies	22% ± 10%	Explore
amacrine cell	4 studies	34% ± 14%	Explore
microglial cell	4 studies	25% ± 13%	Explore
adventitial cell	4 studies	24% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	33% ± 4%	Explore
innate lymphoid cell	4 studies	21% ± 5%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	28% ± 6%	Explore
T-helper 17 cell	4 studies	26% ± 9%	Explore
plasmablast	3 studies	46% ± 15%	Explore
deuterosomal cell	3 studies	37% ± 5%	Explore
duct epithelial cell	3 studies	33% ± 8%	Explore
pancreatic A cell	3 studies	56% ± 18%	Explore
type B pancreatic cell	3 studies	54% ± 18%	Explore
glomerular endothelial cell	3 studies	22% ± 4%	Explore
erythroblast	3 studies	36% ± 13%	Explore
hematopoietic stem cell	3 studies	25% ± 6%	Explore
lymphocyte	3 studies	33% ± 9%	Explore
retinal cone cell	3 studies	54% ± 14%	Explore
retinal rod cell	3 studies	31% ± 5%	Explore
serous secreting cell	3 studies	37% ± 8%	Explore
intraepithelial lymphocyte	3 studies	26% ± 6%	Explore
intermediate monocyte	3 studies	46% ± 10%	Explore
mesothelial cell	3 studies	30% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	38% ± 7%	Explore
oligodendrocyte precursor cell	3 studies	23% ± 5%	Explore
granulocyte monocyte progenitor cell	3 studies	33% ± 12%	Explore
enteroendocrine cell	3 studies	44% ± 17%	Explore
glial cell	3 studies	31% ± 14%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 14%	Explore
keratinocyte	3 studies	21% ± 2%	Explore
double negative thymocyte	3 studies	37% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	25% ± 8%	Explore
progenitor cell of mammary luminal epithelium	3 studies	31% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	33% ± 12%	Explore
peripheral blood	13 studies	30% ± 9%	Explore
intestine	11 studies	25% ± 12%	Explore
kidney	8 studies	30% ± 8%	Explore
eye	5 studies	29% ± 11%	Explore
uterus	4 studies	36% ± 16%	Explore
liver	4 studies	30% ± 16%	Explore
lymph node	4 studies	28% ± 13%	Explore
breast	4 studies	26% ± 6%	Explore
pancreas	3 studies	49% ± 22%	Explore
bone marrow	3 studies	22% ± 3%	Explore
brain	3 studies	28% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	2140.57	258 / 258	100%	133.14	230 / 230
esophagus	100%	2207.79	1445 / 1445	100%	48.09	183 / 183
liver	100%	1398.11	226 / 226	100%	99.22	406 / 406
ovary	100%	1278.17	180 / 180	100%	82.79	430 / 430
thymus	100%	2100.42	653 / 653	100%	112.07	605 / 605
uterus	100%	1536.39	170 / 170	100%	99.24	459 / 459
brain	100%	2357.38	2638 / 2642	100%	122.75	705 / 705
skin	100%	2058.64	1809 / 1809	100%	111.04	470 / 472
kidney	100%	2720.46	89 / 89	100%	115.69	897 / 901
intestine	100%	2154.78	966 / 966	99%	112.87	523 / 527
prostate	100%	1801.02	245 / 245	99%	119.92	498 / 502
stomach	100%	1629.99	359 / 359	99%	87.51	283 / 286
bladder	100%	2071.90	21 / 21	99%	114.27	497 / 504
pancreas	99%	1100.08	325 / 328	99%	95.70	177 / 178
breast	100%	2042.41	459 / 459	98%	87.30	1099 / 1118
lung	100%	1592.51	576 / 578	99%	75.82	1139 / 1155
adipose	100%	2067.04	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	156.31	80 / 80
lymph node	0%	0	0 / 0	100%	145.43	29 / 29
spleen	100%	1554.52	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	105.12	45 / 45
ureter	0%	0	0 / 0	100%	148.07	1 / 1
muscle	100%	3103.17	802 / 803	0%	0	0 / 0
blood vessel	100%	2015.28	1331 / 1335	0%	0	0 / 0
heart	99%	3615.94	856 / 861	0%	0	0 / 0
peripheral blood	74%	820.59	686 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	MICOS13
Protein name	MICOS complex subunit MIC13 MICOS complex subunit MIC13 (Protein P117)
Synonyms	MIC13 C19orf70 QIL1
Description	FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex. . FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. . FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. . FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. .
Accessions	K7EIR2 ENST00000590389.5 A0A140TA86 ENST00000587589.1 A0A140TA84 ENST00000309324.9 ENST00000587950.5 Q5XKP0

GO_0007007	Biological process	inner mitochondrial membrane organization
GO_0042407	Biological process	cristae formation
GO_0001401	Cellular component	SAM complex
GO_0005654	Cellular component	nucleoplasm
GO_0044284	Cellular component	mitochondrial crista junction
GO_0061617	Cellular component	MICOS complex
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0140275	Cellular component	MIB complex
GO_0005515	Molecular function	protein binding

MICOS13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review