MAGOH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050684Biological processregulation of mRNA processing
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0006406Biological processmRNA export from nucleus
GO_0008380Biological processRNA splicing
GO_2000622Biological processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0006417Biological processregulation of translation
GO_0016607Cellular componentnuclear speck
GO_0035145Cellular componentexon-exon junction complex
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_1990501Cellular componentexon-exon junction subcomplex mago-y14
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameMAGOH
Protein nameProtein mago nashi homolog
SynonymsMAGOHA
DescriptionFUNCTION: Required for pre-mRNA splicing as component of the spliceosome . Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway . The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. .

AccessionsP61326
ENST00000371466.4 [P61326-2]
ENST00000371470.8 [P61326-1]