LY6E report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046597Biological processnegative regulation of viral entry into host cell
GO_0007166Biological processcell surface receptor signaling pathway
GO_0098552Cellular componentside of membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0030550Molecular functionacetylcholine receptor inhibitor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLY6E
Protein nameLymphocyte antigen 6E (Ly-6E) (Retinoic acid-induced gene E protein) (RIG-E) (Stem cell antigen 2) (SCA-2) (Thymic shared antigen 1) (TSA-1)
Lymphocyte antigen 6 family member E (Lymphocyte antigen 6E)
SynonymsTSA1
9804
RIGE
SCA2
DescriptionFUNCTION: GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (By similarity). Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion . Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (By similarity). .; FUNCTION: (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus . In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E . Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape . .

AccessionsENST00000520531.5
Q16553
ENST00000631568.1
ENST00000619718.2
ENST00000633934.1
E7EWF8
ENST00000633898.1
ENST00000292494.11
E5RI33
ENST00000522024.1
ENST00000632978.1
ENST00000522971.5
E5RIQ1
ENST00000521699.5
ENST00000632516.1
ENST00000521182.5
ENST00000632902.1
ENST00000429120.6
ENST00000523847.5
ENST00000521003.5
ENST00000632232.1
ENST00000517503.1
E5RGI6
ENST00000519546.5
ENST00000632618.1
ENST00000633451.1
ENST00000632519.1
ENST00000632812.1
ENST00000633551.1
ENST00000519611.5
ENST00000520466.5
ENST00000632424.1
ENST00000522528.5
E5RI58