JTB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008637Biological processapoptotic mitochondrial changes
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0000281Biological processmitotic cytokinesis
GO_0000278Biological processmitotic cell cycle
GO_0042127Biological processregulation of cell population proliferation
GO_0005813Cellular componentcentrosome
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0005819Cellular componentspindle
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0019901Molecular functionprotein kinase binding

IV. Literature review

[source]
Gene nameJTB
Protein nameProtein JTB (Jumping translocation breakpoint protein) (Prostate androgen-regulated protein) (PAR protein)
SynonymsHSPC222
DescriptionFUNCTION: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity). .

AccessionsENST00000356648.5 [O76095-2]
O76095
ENST00000368589.5 [O76095-2]
ENST00000271843.9 [O76095-1]
ENST00000428469.1 [O76095-2]