IK | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	32 studies	30% ± 9%	Explore
B cell	29 studies	25% ± 7%	Explore
CD8-positive, alpha-beta T cell	28 studies	27% ± 8%	Explore
CD4-positive, alpha-beta T cell	27 studies	27% ± 9%	Explore
T cell	25 studies	25% ± 6%	Explore
endothelial cell	21 studies	28% ± 10%	Explore
regulatory T cell	21 studies	29% ± 7%	Explore
fibroblast	20 studies	24% ± 9%	Explore
smooth muscle cell	20 studies	25% ± 8%	Explore
ciliated cell	19 studies	73% ± 22%	Explore
pericyte	18 studies	26% ± 7%	Explore
naive B cell	16 studies	24% ± 7%	Explore
memory B cell	16 studies	24% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	31% ± 9%	Explore
non-classical monocyte	15 studies	30% ± 14%	Explore
gamma-delta T cell	15 studies	32% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	30% ± 9%	Explore
plasmacytoid dendritic cell	14 studies	30% ± 11%	Explore
conventional dendritic cell	14 studies	27% ± 16%	Explore
mature NK T cell	14 studies	28% ± 6%	Explore
macrophage	13 studies	20% ± 8%	Explore
classical monocyte	13 studies	27% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	32% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	29% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	30% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	33% ± 9%	Explore
epithelial cell	11 studies	36% ± 20%	Explore
mucosal invariant T cell	11 studies	28% ± 5%	Explore
monocyte	10 studies	22% ± 4%	Explore
basal cell	10 studies	28% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	36% ± 9%	Explore
vein endothelial cell	9 studies	20% ± 4%	Explore
mast cell	8 studies	24% ± 6%	Explore
endothelial cell of lymphatic vessel	8 studies	28% ± 6%	Explore
plasmablast	8 studies	36% ± 20%	Explore
myofibroblast cell	8 studies	28% ± 3%	Explore
connective tissue cell	8 studies	24% ± 6%	Explore
endothelial cell of artery	8 studies	21% ± 4%	Explore
dendritic cell	7 studies	31% ± 21%	Explore
secretory cell	7 studies	26% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	31% ± 10%	Explore
capillary endothelial cell	7 studies	24% ± 3%	Explore
endothelial cell of vascular tree	7 studies	24% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	29% ± 10%	Explore
innate lymphoid cell	6 studies	26% ± 7%	Explore
T follicular helper cell	6 studies	28% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	34% ± 11%	Explore
plasma cell	5 studies	32% ± 13%	Explore
respiratory goblet cell	5 studies	24% ± 10%	Explore
abnormal cell	5 studies	27% ± 10%	Explore
precursor B cell	5 studies	30% ± 10%	Explore
pro-B cell	5 studies	31% ± 8%	Explore
myeloid cell	5 studies	31% ± 12%	Explore
goblet cell	5 studies	24% ± 4%	Explore
erythrocyte	5 studies	29% ± 18%	Explore
type I pneumocyte	4 studies	25% ± 6%	Explore
hematopoietic precursor cell	4 studies	36% ± 11%	Explore
deuterosomal cell	4 studies	51% ± 5%	Explore
pancreatic A cell	4 studies	29% ± 7%	Explore
leukocyte	4 studies	35% ± 10%	Explore
exhausted T cell	4 studies	35% ± 12%	Explore
immature B cell	4 studies	23% ± 8%	Explore
retinal rod cell	4 studies	31% ± 14%	Explore
erythroblast	4 studies	39% ± 19%	Explore
neuron	4 studies	30% ± 15%	Explore
T-helper 17 cell	4 studies	25% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	26% ± 7%	Explore
double negative thymocyte	4 studies	42% ± 13%	Explore
type B pancreatic cell	3 studies	39% ± 9%	Explore
mononuclear phagocyte	3 studies	27% ± 8%	Explore
glomerular endothelial cell	3 studies	20% ± 4%	Explore
kidney loop of Henle epithelial cell	3 studies	18% ± 1%	Explore
progenitor cell	3 studies	21% ± 4%	Explore
neural crest cell	3 studies	25% ± 5%	Explore
retinal bipolar neuron	3 studies	35% ± 13%	Explore
lymphocyte	3 studies	32% ± 13%	Explore
club cell	3 studies	31% ± 9%	Explore
type II pneumocyte	3 studies	22% ± 8%	Explore
amacrine cell	3 studies	35% ± 12%	Explore
retina horizontal cell	3 studies	28% ± 12%	Explore
retinal cone cell	3 studies	44% ± 11%	Explore
Mueller cell	3 studies	24% ± 6%	Explore
germinal center B cell	3 studies	20% ± 3%	Explore
CD4-positive helper T cell	3 studies	32% ± 9%	Explore
mesothelial cell	3 studies	28% ± 17%	Explore
GABAergic neuron	3 studies	24% ± 6%	Explore
glutamatergic neuron	3 studies	31% ± 8%	Explore
granulocyte	3 studies	22% ± 6%	Explore
intestinal crypt stem cell	3 studies	20% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 10%	Explore
T-helper 1 cell	3 studies	28% ± 9%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	34% ± 2%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	31% ± 8%	Explore
hematopoietic stem cell	3 studies	27% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	31% ± 10%	Explore
lung	15 studies	28% ± 12%	Explore
intestine	8 studies	21% ± 8%	Explore
eye	5 studies	29% ± 13%	Explore
lymph node	5 studies	23% ± 5%	Explore
kidney	4 studies	23% ± 4%	Explore
bone marrow	4 studies	23% ± 8%	Explore
uterus	4 studies	34% ± 15%	Explore
brain	4 studies	24% ± 3%	Explore
pancreas	3 studies	34% ± 6%	Explore
liver	3 studies	37% ± 20%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6273.56	1445 / 1445	100%	58.98	183 / 183
lung	100%	6040.81	578 / 578	100%	69.11	1155 / 1155
ovary	100%	6448.89	180 / 180	100%	62.38	430 / 430
prostate	100%	5272.68	245 / 245	100%	87.39	502 / 502
stomach	100%	4408.74	359 / 359	100%	63.97	286 / 286
thymus	100%	6304.56	653 / 653	100%	115.97	605 / 605
uterus	100%	6618.12	170 / 170	100%	97.43	459 / 459
intestine	100%	6428.98	966 / 966	100%	71.44	526 / 527
skin	100%	6396.33	1809 / 1809	100%	87.87	471 / 472
kidney	100%	4353.91	89 / 89	100%	84.33	899 / 901
brain	100%	4794.64	2636 / 2642	100%	93.81	705 / 705
breast	100%	6310.19	459 / 459	100%	99.47	1115 / 1118
bladder	100%	6130.33	21 / 21	100%	74.71	502 / 504
adrenal gland	100%	5581.31	258 / 258	100%	81.00	229 / 230
liver	100%	2527.93	225 / 226	100%	61.64	406 / 406
pancreas	98%	2478.44	320 / 328	100%	78.94	178 / 178
adipose	100%	6160.84	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7124.37	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	73.05	80 / 80
lymph node	0%	0	0 / 0	100%	119.98	29 / 29
muscle	100%	6917.70	803 / 803	0%	0	0 / 0
spleen	100%	6427.98	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	95.41	45 / 45
ureter	0%	0	0 / 0	100%	23.15	1 / 1
peripheral blood	99%	6014.95	923 / 929	0%	0	0 / 0
heart	98%	3991.12	846 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0034501	Biological process	protein localization to kinetochore
GO_0007094	Biological process	mitotic spindle assembly checkpoint signaling
GO_0000278	Biological process	mitotic cell cycle
GO_0000228	Cellular component	nuclear chromosome
GO_0016607	Cellular component	nuclear speck
GO_0097431	Cellular component	mitotic spindle pole
GO_0005654	Cellular component	nucleoplasm
GO_0071005	Cellular component	U2-type precatalytic spliceosome
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	IK
Protein name	Protein Red (Cytokine IK) (IK factor) (Protein RER) IK cytokine IK cytokine, down-regulator of HLA II
Synonyms	RED RER
Description	FUNCTION: Involved in pre-mRNA splicing as a component of the spliceosome . Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression . Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint . Required for normal accumulation of SMU1 . .; FUNCTION: (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles. .
Accessions	ENST00000513256.5 ENST00000417647.7 ENST00000508301.5 ENST00000502899.2 D6RAY9 Q13123 E7EQZ7 D6RCQ4 Q95HA6 ENST00000507593.5 D6REL4 D6RAH1 ENST00000503332.5

IK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review