HLA-DRA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050870Biological processpositive regulation of T cell activation
GO_0002469Biological processmyeloid dendritic cell antigen processing and presentation
GO_0043382Biological processpositive regulation of memory T cell differentiation
GO_2000516Biological processpositive regulation of CD4-positive, alpha-beta T cell activation
GO_0032831Biological processpositive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO_0002503Biological processpeptide antigen assembly with MHC class II protein complex
GO_0001916Biological processpositive regulation of T cell mediated cytotoxicity
GO_0045622Biological processregulation of T-helper cell differentiation
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0002491Biological processantigen processing and presentation of endogenous peptide antigen via MHC class II
GO_0019886Biological processantigen processing and presentation of exogenous peptide antigen via MHC class II
GO_0050890Biological processcognition
GO_0050778Biological processpositive regulation of immune response
GO_0002504Biological processantigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO_0001772Cellular componentimmunological synapse
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0120281Cellular componentautolysosome membrane
GO_0030666Cellular componentendocytic vesicle membrane
GO_0031901Cellular componentearly endosome membrane
GO_0005764Cellular componentlysosome
GO_0070062Cellular componentextracellular exosome
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0009986Cellular componentcell surface
GO_0000139Cellular componentGolgi membrane
GO_0098553Cellular componentlumenal side of endoplasmic reticulum membrane
GO_0042613Cellular componentMHC class II protein complex
GO_0012507Cellular componentER to Golgi transport vesicle membrane
GO_0030658Cellular componenttransport vesicle membrane
GO_0005765Cellular componentlysosomal membrane
GO_0042608Molecular functionT cell receptor binding
GO_0030247Molecular functionpolysaccharide binding
GO_0023026Molecular functionMHC class II protein complex binding
GO_0032395Molecular functionMHC class II receptor activity
GO_0005515Molecular functionprotein binding
GO_0042605Molecular functionpeptide antigen binding

IV. Literature review

[source]
Gene nameHLA-DRA
Protein nameHLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA)
MHC class II antigen
HLA class II histocompatibility antigen, DR alpha chain (MHC cell surface glycoprotein) (Major histocompatibility complex, class II, DR alpha)
HLA-DRA protein
HLA class II histocompatibility antigen, DR alpha chain
HLA-DRA
HLA-DRA (MHC class II antigen)
SynonymsHLA-DRA1
DescriptionFUNCTION: An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells . Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes . In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins . Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance . The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides . The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules . .

AccessionsA1A436
ENST00000395388.7
ENST00000415767.2
ENST00000411524.6
ENST00000613328
ENST00000416883.6
ENST00000383259.6
ENST00000427753.2
ENST00000411505.2
A0A0G2JMH6
ENST00000442960.6
ENST00000613328.1
ENST00000383258.3
Q30125
P01903
A1A435
A0A0G2JH46
B0UXD8
ENST00000383127.6
Q30118
ENST00000374982.5
ENST00000418111.2
ENST00000414698.6
A0A1V0E3V4
ENST00000434866.2