G3BP2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	31 studies	28% ± 10%	Explore
CD8-positive, alpha-beta T cell	30 studies	29% ± 10%	Explore
B cell	29 studies	27% ± 10%	Explore
CD4-positive, alpha-beta T cell	29 studies	30% ± 9%	Explore
T cell	23 studies	31% ± 11%	Explore
endothelial cell	21 studies	27% ± 10%	Explore
regulatory T cell	21 studies	35% ± 8%	Explore
conventional dendritic cell	20 studies	25% ± 11%	Explore
memory B cell	19 studies	28% ± 9%	Explore
mast cell	18 studies	28% ± 13%	Explore
mature NK T cell	16 studies	29% ± 12%	Explore
gamma-delta T cell	16 studies	36% ± 13%	Explore
mucosal invariant T cell	14 studies	39% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	33% ± 14%	Explore
naive B cell	14 studies	26% ± 8%	Explore
macrophage	13 studies	21% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	27% ± 8%	Explore
ciliated cell	13 studies	31% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	30% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	30% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	34% ± 13%	Explore
non-classical monocyte	12 studies	27% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	31% ± 12%	Explore
glutamatergic neuron	11 studies	42% ± 21%	Explore
plasmacytoid dendritic cell	11 studies	29% ± 9%	Explore
dendritic cell	10 studies	32% ± 18%	Explore
classical monocyte	10 studies	24% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	33% ± 13%	Explore
monocyte	9 studies	21% ± 4%	Explore
fibroblast	9 studies	22% ± 4%	Explore
epithelial cell	9 studies	35% ± 19%	Explore
GABAergic neuron	9 studies	41% ± 19%	Explore
platelet	8 studies	24% ± 6%	Explore
neuron	8 studies	32% ± 13%	Explore
oligodendrocyte	8 studies	25% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	26% ± 6%	Explore
leukocyte	7 studies	28% ± 9%	Explore
interneuron	7 studies	39% ± 23%	Explore
hematopoietic stem cell	7 studies	24% ± 10%	Explore
innate lymphoid cell	7 studies	29% ± 8%	Explore
basal cell	7 studies	31% ± 10%	Explore
T follicular helper cell	7 studies	33% ± 10%	Explore
oligodendrocyte precursor cell	7 studies	28% ± 8%	Explore
smooth muscle cell	6 studies	23% ± 6%	Explore
plasmablast	6 studies	37% ± 17%	Explore
goblet cell	6 studies	27% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	36% ± 18%	Explore
pericyte	5 studies	24% ± 7%	Explore
CD4-positive helper T cell	5 studies	31% ± 16%	Explore
hematopoietic precursor cell	5 studies	30% ± 12%	Explore
plasma cell	5 studies	27% ± 13%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	31% ± 3%	Explore
lymphocyte	5 studies	29% ± 16%	Explore
vein endothelial cell	5 studies	20% ± 5%	Explore
astrocyte	5 studies	26% ± 9%	Explore
alveolar macrophage	5 studies	20% ± 4%	Explore
endothelial cell of lymphatic vessel	4 studies	23% ± 6%	Explore
pancreatic A cell	4 studies	34% ± 18%	Explore
exhausted T cell	4 studies	27% ± 6%	Explore
abnormal cell	4 studies	24% ± 7%	Explore
microglial cell	4 studies	22% ± 4%	Explore
megakaryocyte	4 studies	40% ± 17%	Explore
precursor B cell	4 studies	22% ± 3%	Explore
immature B cell	4 studies	23% ± 3%	Explore
retina horizontal cell	4 studies	19% ± 3%	Explore
secretory cell	4 studies	25% ± 10%	Explore
granulocyte	4 studies	28% ± 10%	Explore
connective tissue cell	4 studies	21% ± 6%	Explore
group 3 innate lymphoid cell	4 studies	51% ± 11%	Explore
endothelial cell of vascular tree	4 studies	20% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	27% ± 6%	Explore
type II pneumocyte	3 studies	23% ± 8%	Explore
type B pancreatic cell	3 studies	51% ± 21%	Explore
mononuclear phagocyte	3 studies	24% ± 8%	Explore
GABAergic interneuron	3 studies	25% ± 4%	Explore
retinal ganglion cell	3 studies	45% ± 21%	Explore
myeloid cell	3 studies	37% ± 2%	Explore
club cell	3 studies	24% ± 7%	Explore
capillary endothelial cell	3 studies	19% ± 3%	Explore
retinal cone cell	3 studies	26% ± 7%	Explore
retinal pigment epithelial cell	3 studies	31% ± 10%	Explore
retinal rod cell	3 studies	17% ± 1%	Explore
endothelial cell of artery	3 studies	19% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	20% ± 4%	Explore
muscle cell	3 studies	33% ± 16%	Explore
pancreatic ductal cell	3 studies	39% ± 18%	Explore
enteroendocrine cell	3 studies	29% ± 8%	Explore
transit amplifying cell	3 studies	25% ± 10%	Explore
T-helper 17 cell	3 studies	38% ± 11%	Explore
granule cell	3 studies	22% ± 5%	Explore
hepatocyte	3 studies	47% ± 20%	Explore
T-helper 1 cell	3 studies	36% ± 11%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	32% ± 11%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	27% ± 9%	Explore
double negative thymocyte	3 studies	43% ± 7%	Explore
double-positive, alpha-beta thymocyte	3 studies	48% ± 12%	Explore
erythrocyte	3 studies	25% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	15 studies	30% ± 10%	Explore
brain	15 studies	31% ± 17%	Explore
lung	9 studies	28% ± 9%	Explore
intestine	6 studies	23% ± 6%	Explore
eye	6 studies	20% ± 7%	Explore
liver	5 studies	27% ± 7%	Explore
kidney	4 studies	19% ± 3%	Explore
bone marrow	4 studies	25% ± 7%	Explore
uterus	4 studies	26% ± 9%	Explore
pancreas	3 studies	43% ± 17%	Explore
breast	3 studies	20% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6069.92	1445 / 1445	100%	37.07	183 / 183
prostate	100%	5907.25	245 / 245	100%	67.40	502 / 502
lung	100%	5561.77	578 / 578	100%	37.69	1153 / 1155
stomach	100%	4712.92	359 / 359	100%	35.07	285 / 286
intestine	100%	6946.86	966 / 966	100%	38.20	525 / 527
breast	100%	5144.88	459 / 459	99%	46.10	1112 / 1118
thymus	100%	5717.46	653 / 653	99%	38.36	599 / 605
brain	99%	7698.49	2617 / 2642	100%	37.75	704 / 705
uterus	100%	5367.55	170 / 170	99%	28.78	453 / 459
bladder	100%	6106.00	21 / 21	98%	31.92	495 / 504
ovary	100%	4603.15	180 / 180	98%	23.49	421 / 430
skin	100%	6158.60	1803 / 1809	97%	40.27	459 / 472
kidney	100%	4458.61	89 / 89	97%	30.94	873 / 901
adrenal gland	100%	5770.95	258 / 258	96%	34.09	220 / 230
pancreas	97%	2715.49	317 / 328	99%	32.26	176 / 178
liver	99%	2695.03	223 / 226	82%	13.21	331 / 406
adipose	100%	5313.24	1204 / 1204	0%	0	0 / 0
blood vessel	100%	6743.54	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	27.88	29 / 29
muscle	100%	10623.45	803 / 803	0%	0	0 / 0
spleen	100%	4857.21	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	32.08	45 / 45
ureter	0%	0	0 / 0	100%	13.54	1 / 1
heart	93%	3590.98	804 / 861	0%	0	0 / 0
peripheral blood	87%	5084.35	811 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	80%	15.18	64 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051260	Biological process	protein homooligomerization
GO_0062029	Biological process	positive regulation of stress granule assembly
GO_0007265	Biological process	Ras protein signal transduction
GO_0007253	Biological process	cytoplasmic sequestering of NF-kappaB
GO_0034063	Biological process	stress granule assembly
GO_0051028	Biological process	mRNA transport
GO_0045087	Biological process	innate immune response
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0005829	Cellular component	cytosol
GO_0010494	Cellular component	cytoplasmic stress granule
GO_0005737	Cellular component	cytoplasm
GO_0140693	Molecular function	molecular condensate scaffold activity
GO_0030159	Molecular function	signaling receptor complex adaptor activity
GO_0005515	Molecular function	protein binding
GO_0003729	Molecular function	mRNA binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	G3BP2
Protein name	Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2) G3BP stress granule assembly factor 2
Synonyms	KIAA0660
Description	FUNCTION: Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling . Plays an essential role in stress granule formation . Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress . Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity). .
Accessions	ENST00000677520.1 ENST00000678123.1 [Q9UN86-1] ENST00000678642.1 ENST00000677489.1 ENST00000678447.1 ENST00000357854.7 [Q9UN86-2] ENST00000677003.1 ENST00000508510.6 ENST00000676584.1 [Q9UN86-1] A0A7I2V382 A0A7I2V481 ENST00000678578.1 [Q9UN86-1] ENST00000676974.1 [Q9UN86-1] ENST00000677889.1 A0A7I2YQS2 ENST00000679281.1 [Q9UN86-2] ENST00000507252.5 Q9UN86 ENST00000510902.2 A0A7I2YQL7 A0A7I2V3I4 A0A7I2V3P9 D6R9A4 ENST00000677952.1 ENST00000678958.1 ENST00000359707.9 [Q9UN86-1] ENST00000678273.1 [Q9UN86-2] ENST00000678062.1 [Q9UN86-1] ENST00000676839.1 [Q9UN86-2] ENST00000677426.1 ENST00000677970.1 ENST00000677171.1 [Q9UN86-1] ENST00000678265.1 [Q9UN86-1] ENST00000509100.6 ENST00000677060.1 ENST00000678329.1 D6RE13 ENST00000677583.1 [Q9UN86-2] A0A7I2YQG8 A0A7I2V3R7 ENST00000678971.1 [Q9UN86-1] D6RBR0 ENST00000677201.1 [Q9UN86-1] ENST00000503660.5 A0A7I2V647 D6RBW8 A0A7I2V2R0 ENST00000678100.1 [Q9UN86-1] ENST00000677620.1 [Q9UN86-1] ENST00000678244.1 ENST00000511146.5 ENST00000511868.6 ENST00000678122.1 [Q9UN86-2] D6RGJ4 ENST00000507745.5 ENST00000676761.1 A0A7I2V3Z6 ENST00000677333.1 [Q9UN86-1] ENST00000676666.1 [Q9UN86-2] A0A7I2V572 ENST00000677125.1 [Q9UN86-2] A0A7I2V513 ENST00000677566.1 [Q9UN86-1] A0A7I2V547 D6RAC7 ENST00000395719.7 [Q9UN86-1] ENST00000677597.1 ENST00000677145.1 ENST00000677727.1 ENST00000676470.1 [Q9UN86-2] ENST00000676702.1 A0A7I2YQD9 ENST00000515457.6 ENST00000677606.1 [Q9UN86-1] ENST00000678798.1 [Q9UN86-1] ENST00000677162.1 [Q9UN86-1] ENST00000677265.1 [Q9UN86-2] ENST00000499709.3 ENST00000509561.6 A0A7I2V3E2 ENST00000678932.1 ENST00000677876.1 [Q9UN86-2] D6RB17 ENST00000676493.1 ENST00000677794.1 ENST00000678552.1 [Q9UN86-2] ENST00000676926.1 ENST00000677278.1 H0YAE3

G3BP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review