FKBP1A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	45 studies	64% ± 26%	Explore
macrophage	36 studies	53% ± 19%	Explore
fibroblast	33 studies	44% ± 15%	Explore
natural killer cell	32 studies	32% ± 13%	Explore
CD8-positive, alpha-beta T cell	31 studies	41% ± 22%	Explore
B cell	30 studies	36% ± 18%	Explore
CD4-positive, alpha-beta T cell	28 studies	40% ± 21%	Explore
T cell	27 studies	38% ± 17%	Explore
conventional dendritic cell	27 studies	64% ± 16%	Explore
classical monocyte	26 studies	61% ± 16%	Explore
pericyte	26 studies	48% ± 25%	Explore
regulatory T cell	24 studies	47% ± 18%	Explore
smooth muscle cell	23 studies	41% ± 16%	Explore
non-classical monocyte	23 studies	78% ± 13%	Explore
monocyte	22 studies	56% ± 21%	Explore
dendritic cell	21 studies	55% ± 25%	Explore
endothelial cell of lymphatic vessel	21 studies	74% ± 16%	Explore
plasmacytoid dendritic cell	20 studies	52% ± 16%	Explore
epithelial cell	19 studies	50% ± 22%	Explore
basal cell	18 studies	45% ± 22%	Explore
connective tissue cell	18 studies	48% ± 22%	Explore
memory B cell	17 studies	30% ± 10%	Explore
naive B cell	16 studies	31% ± 9%	Explore
endothelial cell of artery	16 studies	67% ± 24%	Explore
capillary endothelial cell	16 studies	67% ± 21%	Explore
mast cell	15 studies	34% ± 15%	Explore
mature NK T cell	15 studies	31% ± 12%	Explore
vein endothelial cell	15 studies	69% ± 25%	Explore
gamma-delta T cell	15 studies	37% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	29% ± 9%	Explore
myeloid cell	14 studies	54% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	32% ± 10%	Explore
ciliated cell	13 studies	41% ± 20%	Explore
myofibroblast cell	13 studies	48% ± 19%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	38% ± 16%	Explore
plasma cell	12 studies	43% ± 15%	Explore
endothelial cell of vascular tree	11 studies	72% ± 20%	Explore
plasmablast	10 studies	53% ± 19%	Explore
platelet	10 studies	53% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	39% ± 21%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	36% ± 21%	Explore
neutrophil	10 studies	42% ± 20%	Explore
secretory cell	10 studies	39% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	36% ± 9%	Explore
mucosal invariant T cell	10 studies	25% ± 6%	Explore
progenitor cell	9 studies	51% ± 17%	Explore
mesothelial cell	9 studies	62% ± 20%	Explore
type I pneumocyte	8 studies	39% ± 15%	Explore
abnormal cell	8 studies	46% ± 16%	Explore
T follicular helper cell	8 studies	42% ± 12%	Explore
hematopoietic stem cell	8 studies	52% ± 17%	Explore
club cell	7 studies	37% ± 15%	Explore
leukocyte	7 studies	44% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	33% ± 10%	Explore
enterocyte	7 studies	30% ± 9%	Explore
goblet cell	7 studies	33% ± 15%	Explore
type II pneumocyte	7 studies	37% ± 17%	Explore
alveolar macrophage	6 studies	55% ± 20%	Explore
hematopoietic precursor cell	6 studies	54% ± 26%	Explore
mononuclear phagocyte	6 studies	57% ± 22%	Explore
epithelial cell of proximal tubule	6 studies	33% ± 11%	Explore
kidney loop of Henle epithelial cell	6 studies	28% ± 8%	Explore
innate lymphoid cell	6 studies	31% ± 11%	Explore
neuron	6 studies	48% ± 21%	Explore
microglial cell	6 studies	29% ± 13%	Explore
erythrocyte	6 studies	39% ± 24%	Explore
CD4-positive helper T cell	5 studies	18% ± 4%	Explore
exhausted T cell	5 studies	57% ± 17%	Explore
ionocyte	5 studies	33% ± 5%	Explore
megakaryocyte	5 studies	70% ± 26%	Explore
enteroendocrine cell	5 studies	54% ± 23%	Explore
precursor B cell	5 studies	59% ± 12%	Explore
pro-B cell	5 studies	55% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	57% ± 19%	Explore
intermediate monocyte	5 studies	74% ± 18%	Explore
oligodendrocyte precursor cell	5 studies	36% ± 16%	Explore
pancreatic A cell	4 studies	59% ± 21%	Explore
type B pancreatic cell	4 studies	52% ± 23%	Explore
glomerular endothelial cell	4 studies	74% ± 8%	Explore
renal alpha-intercalated cell	4 studies	44% ± 20%	Explore
intestinal crypt stem cell	4 studies	41% ± 7%	Explore
transit amplifying cell	4 studies	40% ± 17%	Explore
erythroblast	4 studies	53% ± 16%	Explore
brush cell	4 studies	31% ± 17%	Explore
immature B cell	4 studies	60% ± 13%	Explore
adventitial cell	4 studies	43% ± 6%	Explore
double negative thymocyte	4 studies	54% ± 21%	Explore
germinal center B cell	4 studies	50% ± 17%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	64% ± 13%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	37% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	50% ± 18%	Explore
glutamatergic neuron	4 studies	28% ± 10%	Explore
glial cell	4 studies	43% ± 28%	Explore
group 3 innate lymphoid cell	4 studies	40% ± 16%	Explore
T-helper 17 cell	4 studies	47% ± 26%	Explore
T-helper 1 cell	4 studies	51% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	27% ± 7%	Explore
duct epithelial cell	3 studies	17% ± 3%	Explore
precursor cell	3 studies	54% ± 12%	Explore
respiratory goblet cell	3 studies	43% ± 27%	Explore
pancreatic D cell	3 studies	56% ± 27%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	55% ± 17%	Explore
neural crest cell	3 studies	56% ± 13%	Explore
extravillous trophoblast	3 studies	64% ± 23%	Explore
lymphocyte	3 studies	59% ± 2%	Explore
neuroendocrine cell	3 studies	59% ± 20%	Explore
mucus secreting cell	3 studies	24% ± 0%	Explore
serous secreting cell	3 studies	31% ± 2%	Explore
tissue-resident macrophage	3 studies	37% ± 18%	Explore
intraepithelial lymphocyte	3 studies	49% ± 11%	Explore
muscle cell	3 studies	28% ± 12%	Explore
myoepithelial cell	3 studies	38% ± 9%	Explore
luminal cell of prostate epithelium	3 studies	34% ± 5%	Explore
pancreatic ductal cell	3 studies	70% ± 12%	Explore
granulocyte	3 studies	45% ± 14%	Explore
keratinocyte	3 studies	41% ± 7%	Explore
progenitor cell of mammary luminal epithelium	3 studies	42% ± 2%	Explore
oligodendrocyte	3 studies	16% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	40% ± 12%	Explore
lung	18 studies	45% ± 19%	Explore
intestine	12 studies	36% ± 19%	Explore
kidney	8 studies	41% ± 13%	Explore
brain	6 studies	30% ± 7%	Explore
pancreas	5 studies	52% ± 25%	Explore
placenta	5 studies	46% ± 19%	Explore
bone marrow	5 studies	31% ± 10%	Explore
uterus	5 studies	46% ± 24%	Explore
liver	5 studies	39% ± 21%	Explore
lymph node	5 studies	46% ± 13%	Explore
prostate	4 studies	31% ± 9%	Explore
breast	4 studies	44% ± 9%	Explore
heart	3 studies	26% ± 8%	Explore
adrenal gland	3 studies	36% ± 9%	Explore
esophagus	3 studies	51% ± 30%	Explore
skin	3 studies	38% ± 13%	Explore
thymus	3 studies	57% ± 30%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	10065.33	21 / 21	100%	129.87	504 / 504
esophagus	100%	9709.14	1445 / 1445	100%	135.21	183 / 183
intestine	100%	9104.42	966 / 966	100%	99.99	527 / 527
ovary	100%	9170.31	180 / 180	100%	177.89	430 / 430
prostate	100%	9410.65	245 / 245	100%	117.86	502 / 502
stomach	100%	6683.48	359 / 359	100%	115.86	286 / 286
thymus	100%	14664.55	653 / 653	100%	128.92	605 / 605
uterus	100%	11076.43	170 / 170	100%	137.24	459 / 459
skin	100%	13771.00	1808 / 1809	100%	180.96	472 / 472
lung	100%	17176.02	578 / 578	100%	122.61	1154 / 1155
kidney	100%	10510.36	89 / 89	100%	101.57	899 / 901
adrenal gland	100%	12250.78	258 / 258	100%	83.27	229 / 230
breast	100%	14311.17	459 / 459	100%	112.72	1113 / 1118
brain	98%	10904.19	2600 / 2642	100%	90.54	705 / 705
pancreas	98%	4488.03	321 / 328	100%	111.64	178 / 178
liver	88%	3542.29	200 / 226	100%	62.14	405 / 406
adipose	100%	18231.56	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	75.57	80 / 80
lymph node	0%	0	0 / 0	100%	148.77	29 / 29
spleen	100%	13123.96	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	121.43	45 / 45
ureter	0%	0	0 / 0	100%	58.42	1 / 1
blood vessel	100%	9387.91	1331 / 1335	0%	0	0 / 0
heart	99%	6958.89	856 / 861	0%	0	0 / 0
peripheral blood	99%	14078.06	916 / 929	0%	0	0 / 0
muscle	97%	4459.96	776 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0022417	Biological process	protein maturation by protein folding
GO_0030512	Biological process	negative regulation of transforming growth factor beta receptor signaling pathway
GO_0060347	Biological process	heart trabecula formation
GO_0032092	Biological process	positive regulation of protein binding
GO_0032880	Biological process	regulation of protein localization
GO_0032926	Biological process	negative regulation of activin receptor signaling pathway
GO_0050776	Biological process	regulation of immune response
GO_0055010	Biological process	ventricular cardiac muscle tissue morphogenesis
GO_0006457	Biological process	protein folding
GO_1990000	Biological process	amyloid fibril formation
GO_0097435	Biological process	supramolecular fiber organization
GO_0006458	Biological process	'de novo' protein folding
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0042026	Biological process	protein refolding
GO_0014809	Biological process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
GO_0060314	Biological process	regulation of ryanodine-sensitive calcium-release channel activity
GO_0042110	Biological process	T cell activation
GO_0003007	Biological process	heart morphogenesis
GO_1902991	Biological process	regulation of amyloid precursor protein catabolic process
GO_0070588	Biological process	calcium ion transmembrane transport
GO_0000413	Biological process	protein peptidyl-prolyl isomerization
GO_0016020	Cellular component	membrane
GO_0030018	Cellular component	Z disc
GO_0014802	Cellular component	terminal cisterna
GO_1990425	Cellular component	ryanodine receptor complex
GO_0098562	Cellular component	cytoplasmic side of membrane
GO_0005829	Cellular component	cytosol
GO_0016529	Cellular component	sarcoplasmic reticulum
GO_0005737	Cellular component	cytoplasm
GO_0033017	Cellular component	sarcoplasmic reticulum membrane
GO_0005527	Molecular function	macrolide binding
GO_0070697	Molecular function	activin receptor binding
GO_0003755	Molecular function	peptidyl-prolyl cis-trans isomerase activity
GO_0030547	Molecular function	signaling receptor inhibitor activity
GO_0034713	Molecular function	type I transforming growth factor beta receptor binding
GO_0016247	Molecular function	channel regulator activity
GO_0044325	Molecular function	transmembrane transporter binding
GO_0070411	Molecular function	I-SMAD binding
GO_0005528	Molecular function	FK506 binding
GO_0005160	Molecular function	transforming growth factor beta receptor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	FKBP1A
Protein name	Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) FKBP prolyl isomerase 1A FK506 binding protein12 (FKBP prolyl isomerase 1A) peptidylprolyl isomerase (EC 5.2.1.8)
Synonyms	FKBP12-Exip3 FKBP12 FKBP12-Exip2 FKBP12-Exin FKBP1
Description	FUNCTION: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. .
Accessions	Q5W0X3 ENST00000439640.5 ENST00000381724 ENST00000677533.1 ENST00000614856.2 ENST00000678136.1 Q0VDC5 ENST00000618612.5 ENST00000381719.8 Q0VDC6 ENST00000677335.1 F6T7Q3 ENST00000612074.5 A0A7I2V3S6 ENST00000381715.4 A0A087WZM5 Q1JUQ5 ENST00000400137.9 P62942 ENST00000678408.1 ENST00000381724.8 Q1JUQ3 A0A087WTS4

FKBP1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review