EIF3M | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	36 studies	36% ± 13%	Explore
natural killer cell	33 studies	32% ± 11%	Explore
fibroblast	32 studies	32% ± 12%	Explore
endothelial cell	31 studies	29% ± 12%	Explore
T cell	30 studies	33% ± 13%	Explore
CD4-positive, alpha-beta T cell	30 studies	41% ± 15%	Explore
CD8-positive, alpha-beta T cell	30 studies	38% ± 15%	Explore
conventional dendritic cell	27 studies	48% ± 15%	Explore
macrophage	25 studies	28% ± 11%	Explore
regulatory T cell	25 studies	40% ± 13%	Explore
classical monocyte	24 studies	41% ± 14%	Explore
non-classical monocyte	23 studies	35% ± 14%	Explore
smooth muscle cell	21 studies	34% ± 13%	Explore
basal cell	21 studies	36% ± 16%	Explore
dendritic cell	20 studies	41% ± 24%	Explore
memory B cell	20 studies	36% ± 9%	Explore
epithelial cell	20 studies	38% ± 20%	Explore
monocyte	19 studies	35% ± 13%	Explore
plasmacytoid dendritic cell	19 studies	42% ± 15%	Explore
pericyte	19 studies	34% ± 11%	Explore
naive B cell	18 studies	33% ± 8%	Explore
mast cell	17 studies	35% ± 14%	Explore
gamma-delta T cell	17 studies	36% ± 15%	Explore
mature NK T cell	16 studies	32% ± 9%	Explore
connective tissue cell	16 studies	44% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	41% ± 12%	Explore
endothelial cell of lymphatic vessel	14 studies	29% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	42% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	30% ± 9%	Explore
plasma cell	13 studies	38% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	33% ± 10%	Explore
mucosal invariant T cell	13 studies	33% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	36% ± 15%	Explore
myofibroblast cell	12 studies	38% ± 16%	Explore
mesothelial cell	12 studies	56% ± 27%	Explore
vein endothelial cell	12 studies	26% ± 10%	Explore
endothelial cell of vascular tree	12 studies	28% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	39% ± 16%	Explore
plasmablast	10 studies	46% ± 22%	Explore
secretory cell	10 studies	38% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	35% ± 13%	Explore
progenitor cell	9 studies	51% ± 16%	Explore
abnormal cell	9 studies	34% ± 7%	Explore
myeloid cell	9 studies	33% ± 14%	Explore
ciliated cell	9 studies	36% ± 11%	Explore
leukocyte	8 studies	35% ± 11%	Explore
capillary endothelial cell	8 studies	26% ± 10%	Explore
innate lymphoid cell	8 studies	39% ± 11%	Explore
neuron	8 studies	35% ± 16%	Explore
endothelial cell of artery	8 studies	24% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	42% ± 17%	Explore
epithelial cell of proximal tubule	7 studies	30% ± 14%	Explore
goblet cell	7 studies	29% ± 10%	Explore
hematopoietic stem cell	7 studies	62% ± 12%	Explore
T follicular helper cell	7 studies	37% ± 5%	Explore
type I pneumocyte	6 studies	27% ± 10%	Explore
hematopoietic precursor cell	6 studies	51% ± 26%	Explore
precursor B cell	6 studies	45% ± 13%	Explore
erythrocyte	6 studies	38% ± 23%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	44% ± 17%	Explore
CD4-positive helper T cell	5 studies	24% ± 9%	Explore
exhausted T cell	5 studies	46% ± 13%	Explore
mononuclear phagocyte	5 studies	44% ± 18%	Explore
kidney loop of Henle epithelial cell	5 studies	19% ± 3%	Explore
transit amplifying cell	5 studies	25% ± 8%	Explore
pro-B cell	5 studies	40% ± 12%	Explore
club cell	5 studies	32% ± 10%	Explore
immature B cell	5 studies	45% ± 20%	Explore
type II pneumocyte	5 studies	31% ± 15%	Explore
alveolar macrophage	5 studies	25% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	53% ± 21%	Explore
granulocyte	5 studies	38% ± 14%	Explore
glutamatergic neuron	5 studies	37% ± 17%	Explore
oligodendrocyte precursor cell	5 studies	34% ± 15%	Explore
podocyte	4 studies	80% ± 17%	Explore
enterocyte	4 studies	28% ± 12%	Explore
enteroendocrine cell	4 studies	43% ± 11%	Explore
intestinal crypt stem cell	4 studies	38% ± 10%	Explore
erythroblast	4 studies	48% ± 16%	Explore
lymphocyte	4 studies	36% ± 15%	Explore
astrocyte	4 studies	24% ± 5%	Explore
microglial cell	4 studies	24% ± 7%	Explore
muscle cell	4 studies	30% ± 14%	Explore
intermediate monocyte	4 studies	47% ± 24%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	29% ± 6%	Explore
GABAergic neuron	4 studies	32% ± 12%	Explore
T-helper 17 cell	4 studies	42% ± 22%	Explore
interneuron	4 studies	29% ± 15%	Explore
oligodendrocyte	4 studies	19% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	30% ± 9%	Explore
double negative thymocyte	4 studies	52% ± 18%	Explore
duct epithelial cell	3 studies	18% ± 1%	Explore
precursor cell	3 studies	58% ± 16%	Explore
respiratory goblet cell	3 studies	31% ± 21%	Explore
type B pancreatic cell	3 studies	31% ± 6%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	56% ± 27%	Explore
neural crest cell	3 studies	57% ± 6%	Explore
extravillous trophoblast	3 studies	42% ± 7%	Explore
placental villous trophoblast	3 studies	48% ± 13%	Explore
common myeloid progenitor	3 studies	51% ± 28%	Explore
megakaryocyte	3 studies	29% ± 2%	Explore
serous secreting cell	3 studies	28% ± 1%	Explore
intraepithelial lymphocyte	3 studies	38% ± 20%	Explore
acinar cell	3 studies	40% ± 19%	Explore
germinal center B cell	3 studies	47% ± 3%	Explore
myoepithelial cell	3 studies	45% ± 16%	Explore
granulocyte monocyte progenitor cell	3 studies	51% ± 18%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	66% ± 24%	Explore
group 3 innate lymphoid cell	3 studies	48% ± 15%	Explore
keratinocyte	3 studies	31% ± 5%	Explore
T-helper 1 cell	3 studies	52% ± 11%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	40% ± 11%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	36% ± 10%	Explore
progenitor cell of mammary luminal epithelium	3 studies	42% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	41% ± 12%	Explore
lung	16 studies	32% ± 12%	Explore
intestine	10 studies	32% ± 15%	Explore
brain	9 studies	27% ± 9%	Explore
kidney	8 studies	32% ± 12%	Explore
eye	6 studies	21% ± 7%	Explore
liver	6 studies	31% ± 20%	Explore
pancreas	5 studies	27% ± 12%	Explore
placenta	5 studies	30% ± 14%	Explore
bone marrow	5 studies	28% ± 9%	Explore
uterus	5 studies	41% ± 16%	Explore
lymph node	5 studies	37% ± 5%	Explore
breast	4 studies	29% ± 7%	Explore
adrenal gland	3 studies	27% ± 7%	Explore
thymus	3 studies	56% ± 26%	Explore
prostate	3 studies	29% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4925.16	1445 / 1445	100%	45.56	183 / 183
lung	100%	4516.76	578 / 578	100%	46.04	1155 / 1155
ovary	100%	8519.56	180 / 180	100%	75.63	430 / 430
pancreas	100%	4707.79	328 / 328	100%	42.06	178 / 178
stomach	100%	4763.00	359 / 359	100%	53.98	286 / 286
uterus	100%	6497.89	170 / 170	100%	53.46	459 / 459
breast	100%	5752.18	459 / 459	100%	53.75	1116 / 1118
bladder	100%	5398.24	21 / 21	100%	51.20	503 / 504
prostate	100%	4609.80	245 / 245	100%	50.87	501 / 502
thymus	100%	4888.14	653 / 653	100%	50.15	603 / 605
intestine	100%	4925.12	966 / 966	100%	58.54	525 / 527
brain	100%	3230.47	2629 / 2642	100%	45.33	705 / 705
kidney	100%	4824.85	89 / 89	99%	36.79	894 / 901
skin	100%	6725.84	1809 / 1809	99%	50.69	468 / 472
liver	99%	2337.13	224 / 226	99%	28.56	401 / 406
adrenal gland	100%	6632.55	258 / 258	97%	32.21	223 / 230
adipose	100%	6146.06	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5247.29	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	74.05	29 / 29
muscle	100%	4322.57	803 / 803	0%	0	0 / 0
spleen	100%	4954.99	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	46.69	45 / 45
ureter	0%	0	0 / 0	100%	12.59	1 / 1
eye	0%	0	0 / 0	99%	48.03	79 / 80
heart	96%	3548.28	826 / 861	0%	0	0 / 0
peripheral blood	95%	5091.06	882 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001732	Biological process	formation of cytoplasmic translation initiation complex
GO_0002183	Biological process	cytoplasmic translational initiation
GO_0006413	Biological process	translational initiation
GO_0033290	Cellular component	eukaryotic 48S preinitiation complex
GO_0005829	Cellular component	cytosol
GO_0071541	Cellular component	eukaryotic translation initiation factor 3 complex, eIF3m
GO_0016282	Cellular component	eukaryotic 43S preinitiation complex
GO_0005852	Cellular component	eukaryotic translation initiation factor 3 complex
GO_0003743	Molecular function	translation initiation factor activity
GO_0031369	Molecular function	translation initiation factor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	EIF3M
Protein name	Eukaryotic translation initiation factor 3 subunit M Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Fetal lung protein B5) (hFL-B5) (PCI domain-containing protein 1)
Synonyms	HFLB5 PCID1 PNAS-125 GA17
Description	FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation . The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression . .; FUNCTION: (Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2). .
Accessions	E9PN86 ENST00000524896.5 [Q7L2H7-2] Q7L2H7 ENST00000525782.5 ENST00000531120.6 [Q7L2H7-1] J3KNJ2 ENST00000533439.1 E7ESM3 ENST00000526267.1 ENST00000323213.9 ENST00000532444.5 H0YCQ8 ENST00000524711.5 E9PRY0 E9PSB3 ENST00000531921.5 E9PRI2

EIF3M report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review