DUSP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	52 studies	61% ± 26%	Explore
endothelial cell	52 studies	55% ± 24%	Explore
fibroblast	47 studies	54% ± 23%	Explore
B cell	43 studies	59% ± 20%	Explore
natural killer cell	42 studies	54% ± 20%	Explore
T cell	35 studies	50% ± 23%	Explore
pericyte	33 studies	56% ± 23%	Explore
CD8-positive, alpha-beta T cell	33 studies	55% ± 19%	Explore
conventional dendritic cell	32 studies	72% ± 19%	Explore
dendritic cell	31 studies	67% ± 23%	Explore
smooth muscle cell	31 studies	55% ± 23%	Explore
CD4-positive, alpha-beta T cell	30 studies	56% ± 22%	Explore
classical monocyte	29 studies	83% ± 16%	Explore
non-classical monocyte	28 studies	87% ± 13%	Explore
monocyte	27 studies	69% ± 21%	Explore
endothelial cell of lymphatic vessel	27 studies	65% ± 20%	Explore
mast cell	25 studies	59% ± 23%	Explore
mature NK T cell	24 studies	57% ± 20%	Explore
regulatory T cell	24 studies	57% ± 23%	Explore
plasma cell	23 studies	49% ± 20%	Explore
epithelial cell	23 studies	58% ± 23%	Explore
basal cell	22 studies	55% ± 22%	Explore
memory B cell	21 studies	59% ± 26%	Explore
gamma-delta T cell	20 studies	59% ± 22%	Explore
naive B cell	20 studies	58% ± 24%	Explore
ciliated cell	19 studies	55% ± 22%	Explore
connective tissue cell	19 studies	53% ± 24%	Explore
CD16-negative, CD56-bright natural killer cell, human	17 studies	61% ± 24%	Explore
plasmacytoid dendritic cell	17 studies	46% ± 13%	Explore
mucosal invariant T cell	16 studies	69% ± 21%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	57% ± 24%	Explore
neutrophil	16 studies	73% ± 17%	Explore
endothelial cell of artery	16 studies	72% ± 18%	Explore
capillary endothelial cell	16 studies	64% ± 19%	Explore
vein endothelial cell	16 studies	53% ± 22%	Explore
myeloid cell	16 studies	64% ± 25%	Explore
myofibroblast cell	15 studies	57% ± 23%	Explore
endothelial cell of vascular tree	15 studies	61% ± 22%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	43% ± 18%	Explore
type I pneumocyte	12 studies	68% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	51% ± 21%	Explore
secretory cell	12 studies	59% ± 17%	Explore
mesothelial cell	12 studies	72% ± 17%	Explore
type II pneumocyte	11 studies	54% ± 21%	Explore
innate lymphoid cell	11 studies	66% ± 19%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	51% ± 20%	Explore
microglial cell	11 studies	49% ± 24%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	60% ± 24%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	64% ± 23%	Explore
goblet cell	10 studies	53% ± 18%	Explore
club cell	9 studies	50% ± 25%	Explore
leukocyte	9 studies	63% ± 16%	Explore
alveolar macrophage	8 studies	69% ± 20%	Explore
plasmablast	8 studies	51% ± 11%	Explore
mononuclear phagocyte	8 studies	72% ± 17%	Explore
erythrocyte	8 studies	47% ± 17%	Explore
progenitor cell	8 studies	43% ± 23%	Explore
abnormal cell	8 studies	55% ± 29%	Explore
T follicular helper cell	8 studies	66% ± 20%	Explore
astrocyte	8 studies	51% ± 21%	Explore
adipocyte	8 studies	42% ± 11%	Explore
respiratory goblet cell	7 studies	38% ± 24%	Explore
enterocyte	7 studies	41% ± 18%	Explore
IgA plasma cell	7 studies	49% ± 21%	Explore
IgG plasma cell	7 studies	46% ± 21%	Explore
precursor B cell	7 studies	59% ± 17%	Explore
immature B cell	7 studies	76% ± 11%	Explore
CD4-positive helper T cell	6 studies	55% ± 23%	Explore
ionocyte	6 studies	36% ± 19%	Explore
renal alpha-intercalated cell	6 studies	52% ± 13%	Explore
hematopoietic stem cell	6 studies	55% ± 26%	Explore
intermediate monocyte	6 studies	87% ± 12%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	46% ± 16%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	50% ± 24%	Explore
hematopoietic precursor cell	5 studies	60% ± 19%	Explore
duct epithelial cell	5 studies	45% ± 20%	Explore
platelet	5 studies	41% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	45% ± 12%	Explore
endothelial cell of sinusoid	5 studies	36% ± 14%	Explore
kidney loop of Henle epithelial cell	5 studies	40% ± 15%	Explore
epithelial cell of proximal tubule	5 studies	34% ± 21%	Explore
transit amplifying cell	5 studies	43% ± 23%	Explore
renal principal cell	5 studies	54% ± 19%	Explore
pro-B cell	5 studies	56% ± 16%	Explore
group 3 innate lymphoid cell	5 studies	91% ± 8%	Explore
adventitial cell	5 studies	67% ± 24%	Explore
Mueller cell	5 studies	58% ± 23%	Explore
inflammatory macrophage	5 studies	58% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	49% ± 19%	Explore
hepatocyte	5 studies	38% ± 24%	Explore
granulocyte	5 studies	69% ± 12%	Explore
keratinocyte	5 studies	56% ± 28%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	57% ± 14%	Explore
squamous epithelial cell	4 studies	60% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	50% ± 21%	Explore
monocyte-derived dendritic cell	4 studies	79% ± 20%	Explore
glomerular endothelial cell	4 studies	85% ± 9%	Explore
kidney connecting tubule epithelial cell	4 studies	56% ± 26%	Explore
podocyte	4 studies	59% ± 18%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	42% ± 13%	Explore
parietal epithelial cell	4 studies	67% ± 13%	Explore
enteroendocrine cell	4 studies	51% ± 12%	Explore
lymphocyte	4 studies	48% ± 26%	Explore
T-helper 17 cell	4 studies	86% ± 11%	Explore
retinal pigment epithelial cell	4 studies	45% ± 15%	Explore
cardiac muscle cell	4 studies	25% ± 7%	Explore
erythroblast	4 studies	38% ± 28%	Explore
acinar cell	4 studies	40% ± 14%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	41% ± 14%	Explore
luminal cell of prostate epithelium	4 studies	53% ± 6%	Explore
glial cell	4 studies	33% ± 10%	Explore
Langerhans cell	3 studies	45% ± 19%	Explore
deuterosomal cell	3 studies	21% ± 4%	Explore
hillock cell	3 studies	35% ± 8%	Explore
precursor cell	3 studies	56% ± 7%	Explore
pancreatic A cell	3 studies	43% ± 9%	Explore
type B pancreatic cell	3 studies	35% ± 7%	Explore
cholangiocyte	3 studies	22% ± 6%	Explore
intestinal crypt stem cell	3 studies	43% ± 14%	Explore
extravillous trophoblast	3 studies	35% ± 20%	Explore
placental villous trophoblast	3 studies	30% ± 13%	Explore
brush cell	3 studies	32% ± 12%	Explore
neuroendocrine cell	3 studies	41% ± 15%	Explore
neuron	3 studies	44% ± 23%	Explore
retina horizontal cell	3 studies	24% ± 6%	Explore
retinal rod cell	3 studies	34% ± 15%	Explore
endocardial cell	3 studies	36% ± 8%	Explore
tissue-resident macrophage	3 studies	76% ± 23%	Explore
intraepithelial lymphocyte	3 studies	45% ± 9%	Explore
germinal center B cell	3 studies	40% ± 8%	Explore
myoepithelial cell	3 studies	60% ± 23%	Explore
muscle cell	3 studies	53% ± 19%	Explore
pancreatic ductal cell	3 studies	74% ± 17%	Explore
oligodendrocyte precursor cell	3 studies	30% ± 13%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	69% ± 15%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	44% ± 31%	Explore
double-positive, alpha-beta thymocyte	3 studies	54% ± 32%	Explore
progenitor cell of mammary luminal epithelium	3 studies	62% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	21 studies	55% ± 20%	Explore
peripheral blood	20 studies	57% ± 19%	Explore
intestine	12 studies	54% ± 23%	Explore
liver	9 studies	36% ± 19%	Explore
kidney	9 studies	46% ± 25%	Explore
eye	7 studies	39% ± 13%	Explore
uterus	6 studies	63% ± 26%	Explore
lymph node	6 studies	63% ± 27%	Explore
pancreas	5 studies	37% ± 14%	Explore
brain	5 studies	31% ± 15%	Explore
placenta	5 studies	37% ± 16%	Explore
heart	5 studies	27% ± 7%	Explore
prostate	5 studies	43% ± 6%	Explore
skin	5 studies	47% ± 24%	Explore
breast	5 studies	54% ± 18%	Explore
bone marrow	4 studies	45% ± 24%	Explore
adipose	4 studies	46% ± 23%	Explore
esophagus	4 studies	55% ± 20%	Explore
stomach	4 studies	26% ± 9%	Explore
ovary	3 studies	41% ± 18%	Explore
adrenal gland	3 studies	57% ± 25%	Explore
thymus	3 studies	47% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	99%	44077.29	242 / 245	98%	892.73	491 / 502
thymus	97%	42427.31	636 / 653	90%	844.06	545 / 605
lung	99%	68773.12	573 / 578	82%	378.33	948 / 1155
esophagus	90%	33979.38	1303 / 1445	83%	369.03	152 / 183
kidney	87%	22891.09	77 / 89	85%	1112.50	765 / 901
breast	100%	56960.43	457 / 459	70%	269.77	787 / 1118
bladder	95%	39363.57	20 / 21	71%	264.77	359 / 504
ovary	95%	49221.37	171 / 180	68%	295.97	293 / 430
liver	81%	32735.42	182 / 226	75%	284.58	304 / 406
uterus	80%	30788.22	136 / 170	73%	369.43	333 / 459
adrenal gland	60%	24099.67	156 / 258	90%	548.64	207 / 230
intestine	71%	23889.53	684 / 966	64%	203.42	339 / 527
stomach	61%	29438.62	218 / 359	65%	230.73	187 / 286
pancreas	31%	5355.23	102 / 328	93%	447.43	166 / 178
skin	93%	60072.59	1687 / 1809	28%	70.56	134 / 472
adipose	100%	74876.50	1200 / 1204	0%	0	0 / 0
blood vessel	100%	86285.57	1330 / 1335	0%	0	0 / 0
spleen	92%	28527.57	222 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	82%	498.85	37 / 45
peripheral blood	78%	51338.42	724 / 929	0%	0	0 / 0
brain	17%	2678.60	438 / 2642	57%	180.38	405 / 705
heart	72%	19286.82	619 / 861	0%	0	0 / 0
muscle	61%	11240.01	490 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	24%	56.30	7 / 29
eye	0%	0	0 / 0	1%	1.73	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0051447	Biological process	negative regulation of meiotic cell cycle
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0007162	Biological process	negative regulation of cell adhesion
GO_0035970	Biological process	peptidyl-threonine dephosphorylation
GO_0035335	Biological process	peptidyl-tyrosine dephosphorylation
GO_0070262	Biological process	peptidyl-serine dephosphorylation
GO_0043409	Biological process	negative regulation of MAPK cascade
GO_1990869	Biological process	cellular response to chemokine
GO_0043407	Biological process	negative regulation of MAP kinase activity
GO_0001706	Biological process	endoderm formation
GO_0090027	Biological process	negative regulation of monocyte chemotaxis
GO_0090266	Biological process	regulation of mitotic cell cycle spindle assembly checkpoint
GO_1903753	Biological process	negative regulation of p38MAPK cascade
GO_0005634	Cellular component	nucleus
GO_0005737	Cellular component	cytoplasm
GO_0017018	Molecular function	myosin phosphatase activity
GO_0017017	Molecular function	MAP kinase tyrosine/serine/threonine phosphatase activity
GO_0008138	Molecular function	protein tyrosine/serine/threonine phosphatase activity
GO_0051019	Molecular function	mitogen-activated protein kinase binding
GO_0008330	Molecular function	protein tyrosine/threonine phosphatase activity
GO_0004722	Molecular function	protein serine/threonine phosphatase activity
GO_0033550	Molecular function	MAP kinase tyrosine phosphatase activity
GO_0005515	Molecular function	protein binding
GO_0004725	Molecular function	protein tyrosine phosphatase activity

Gene name	DUSP1
Protein name	Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100)
Synonyms	CL100 VH1 PTPN10 MKP1
Description	FUNCTION: Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. .
Accessions	P28562 ENST00000239223.4

DUSP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review