DSTN | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	48 studies	56% ± 22%	Explore
fibroblast	46 studies	62% ± 22%	Explore
pericyte	37 studies	69% ± 25%	Explore
smooth muscle cell	34 studies	79% ± 22%	Explore
natural killer cell	31 studies	34% ± 13%	Explore
macrophage	30 studies	27% ± 9%	Explore
CD4-positive, alpha-beta T cell	29 studies	27% ± 9%	Explore
T cell	26 studies	29% ± 17%	Explore
CD8-positive, alpha-beta T cell	25 studies	28% ± 10%	Explore
endothelial cell of lymphatic vessel	24 studies	57% ± 20%	Explore
epithelial cell	24 studies	68% ± 20%	Explore
basal cell	21 studies	69% ± 19%	Explore
ciliated cell	20 studies	76% ± 22%	Explore
mast cell	19 studies	36% ± 15%	Explore
plasmacytoid dendritic cell	19 studies	50% ± 15%	Explore
connective tissue cell	19 studies	68% ± 18%	Explore
conventional dendritic cell	18 studies	26% ± 11%	Explore
mature NK T cell	17 studies	33% ± 11%	Explore
non-classical monocyte	17 studies	30% ± 14%	Explore
gamma-delta T cell	17 studies	32% ± 13%	Explore
myofibroblast cell	16 studies	79% ± 16%	Explore
capillary endothelial cell	15 studies	49% ± 15%	Explore
endothelial cell of artery	14 studies	62% ± 16%	Explore
regulatory T cell	14 studies	21% ± 6%	Explore
plasma cell	13 studies	37% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	39% ± 9%	Explore
astrocyte	13 studies	34% ± 19%	Explore
vein endothelial cell	13 studies	61% ± 15%	Explore
endothelial cell of vascular tree	13 studies	68% ± 19%	Explore
type I pneumocyte	12 studies	78% ± 15%	Explore
type II pneumocyte	12 studies	66% ± 26%	Explore
club cell	12 studies	62% ± 25%	Explore
secretory cell	12 studies	73% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	23% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	26% ± 8%	Explore
goblet cell	12 studies	51% ± 21%	Explore
mesothelial cell	12 studies	59% ± 24%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	26% ± 9%	Explore
glutamatergic neuron	11 studies	39% ± 18%	Explore
mucosal invariant T cell	11 studies	25% ± 6%	Explore
dendritic cell	10 studies	36% ± 23%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	29% ± 6%	Explore
classical monocyte	10 studies	22% ± 5%	Explore
progenitor cell	10 studies	51% ± 25%	Explore
neuron	10 studies	51% ± 23%	Explore
oligodendrocyte	10 studies	27% ± 11%	Explore
monocyte	9 studies	26% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	28% ± 7%	Explore
GABAergic neuron	9 studies	32% ± 13%	Explore
oligodendrocyte precursor cell	9 studies	34% ± 14%	Explore
respiratory goblet cell	8 studies	60% ± 23%	Explore
leukocyte	8 studies	30% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	30% ± 8%	Explore
abnormal cell	8 studies	59% ± 24%	Explore
myeloid cell	8 studies	31% ± 14%	Explore
ionocyte	7 studies	76% ± 13%	Explore
platelet	7 studies	27% ± 10%	Explore
epithelial cell of proximal tubule	7 studies	59% ± 17%	Explore
hematopoietic stem cell	7 studies	19% ± 3%	Explore
alveolar macrophage	6 studies	33% ± 12%	Explore
plasmablast	6 studies	39% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	37% ± 8%	Explore
kidney loop of Henle epithelial cell	6 studies	78% ± 11%	Explore
renal alpha-intercalated cell	6 studies	73% ± 6%	Explore
enterocyte	6 studies	34% ± 9%	Explore
transit amplifying cell	6 studies	47% ± 25%	Explore
retinal ganglion cell	6 studies	67% ± 33%	Explore
retinal cone cell	6 studies	48% ± 28%	Explore
erythroblast	6 studies	32% ± 15%	Explore
innate lymphoid cell	6 studies	24% ± 4%	Explore
cardiac muscle cell	6 studies	45% ± 8%	Explore
T follicular helper cell	6 studies	19% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	34% ± 9%	Explore
interneuron	6 studies	37% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	28% ± 13%	Explore
hematopoietic precursor cell	5 studies	34% ± 11%	Explore
duct epithelial cell	5 studies	70% ± 23%	Explore
mononuclear phagocyte	5 studies	34% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	84% ± 4%	Explore
enteroendocrine cell	5 studies	59% ± 21%	Explore
intestinal crypt stem cell	5 studies	48% ± 22%	Explore
B cell	5 studies	29% ± 8%	Explore
IgA plasma cell	5 studies	21% ± 5%	Explore
microglial cell	5 studies	29% ± 13%	Explore
retinal rod cell	5 studies	41% ± 15%	Explore
lymphocyte	5 studies	40% ± 23%	Explore
brush cell	5 studies	38% ± 29%	Explore
neuroendocrine cell	5 studies	81% ± 15%	Explore
mucus secreting cell	5 studies	58% ± 23%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	35% ± 8%	Explore
deuterosomal cell	4 studies	69% ± 17%	Explore
squamous epithelial cell	4 studies	57% ± 26%	Explore
pancreatic A cell	4 studies	89% ± 9%	Explore
type B pancreatic cell	4 studies	87% ± 12%	Explore
glomerular endothelial cell	4 studies	60% ± 11%	Explore
podocyte	4 studies	89% ± 2%	Explore
IgG plasma cell	4 studies	20% ± 4%	Explore
amacrine cell	4 studies	56% ± 19%	Explore
retina horizontal cell	4 studies	61% ± 18%	Explore
adventitial cell	4 studies	72% ± 10%	Explore
Mueller cell	4 studies	64% ± 23%	Explore
acinar cell	4 studies	71% ± 23%	Explore
muscle cell	4 studies	64% ± 30%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	94% ± 4%	Explore
myoepithelial cell	4 studies	70% ± 17%	Explore
luminal cell of prostate epithelium	4 studies	65% ± 26%	Explore
hepatocyte	4 studies	53% ± 21%	Explore
melanocyte	4 studies	57% ± 21%	Explore
keratinocyte	4 studies	67% ± 31%	Explore
T-helper 17 cell	4 studies	30% ± 13%	Explore
pancreatic D cell	3 studies	92% ± 8%	Explore
kidney connecting tubule epithelial cell	3 studies	84% ± 10%	Explore
neural crest cell	3 studies	52% ± 9%	Explore
retinal bipolar neuron	3 studies	50% ± 22%	Explore
OFF-bipolar cell	3 studies	57% ± 32%	Explore
ON-bipolar cell	3 studies	55% ± 33%	Explore
GABAergic amacrine cell	3 studies	35% ± 12%	Explore
renal principal cell	3 studies	76% ± 8%	Explore
extravillous trophoblast	3 studies	98% ± 2%	Explore
placental villous trophoblast	3 studies	92% ± 3%	Explore
common myeloid progenitor	3 studies	27% ± 16%	Explore
retinal pigment epithelial cell	3 studies	47% ± 22%	Explore
serous secreting cell	3 studies	72% ± 9%	Explore
rod bipolar cell	3 studies	36% ± 13%	Explore
chondrocyte	3 studies	46% ± 22%	Explore
endothelial cell of sinusoid	3 studies	33% ± 13%	Explore
germinal center B cell	3 studies	22% ± 2%	Explore
intermediate monocyte	3 studies	31% ± 16%	Explore
CD4-positive helper T cell	3 studies	24% ± 6%	Explore
adipocyte	3 studies	41% ± 30%	Explore
granulocyte	3 studies	35% ± 7%	Explore
pancreatic ductal cell	3 studies	88% ± 3%	Explore
granulocyte monocyte progenitor cell	3 studies	32% ± 12%	Explore
megakaryocyte	3 studies	39% ± 12%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	42% ± 19%	Explore
glial cell	3 studies	41% ± 20%	Explore
erythrocyte	3 studies	40% ± 16%	Explore
group 3 innate lymphoid cell	3 studies	28% ± 15%	Explore
granule cell	3 studies	29% ± 6%	Explore
T-helper 1 cell	3 studies	28% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	30% ± 5%	Explore
double negative thymocyte	3 studies	47% ± 18%	Explore
progenitor cell of mammary luminal epithelium	3 studies	79% ± 17%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	20 studies	51% ± 21%	Explore
brain	16 studies	31% ± 12%	Explore
peripheral blood	15 studies	27% ± 7%	Explore
intestine	13 studies	38% ± 22%	Explore
kidney	9 studies	47% ± 15%	Explore
eye	9 studies	47% ± 15%	Explore
heart	6 studies	31% ± 10%	Explore
pancreas	5 studies	75% ± 27%	Explore
placenta	5 studies	60% ± 30%	Explore
uterus	5 studies	68% ± 17%	Explore
prostate	5 studies	56% ± 23%	Explore
liver	5 studies	37% ± 15%	Explore
bone marrow	4 studies	27% ± 10%	Explore
esophagus	4 studies	55% ± 29%	Explore
breast	4 studies	67% ± 13%	Explore
adrenal gland	3 studies	35% ± 4%	Explore
skin	3 studies	59% ± 27%	Explore
thymus	3 studies	47% ± 12%	Explore
lymph node	3 studies	45% ± 22%	Explore
adipose	3 studies	28% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
uterus	100%	52267.39	170 / 170	100%	354.68	459 / 459
bladder	100%	67495.90	21 / 21	100%	350.70	502 / 504
prostate	98%	42328.76	239 / 245	100%	571.97	502 / 502
lung	97%	31966.55	563 / 578	100%	373.59	1152 / 1155
esophagus	98%	90235.11	1410 / 1445	99%	322.53	182 / 183
thymus	95%	23663.94	619 / 653	100%	312.83	602 / 605
breast	95%	24088.38	434 / 459	100%	523.26	1115 / 1118
intestine	90%	69590.82	872 / 966	100%	346.30	526 / 527
skin	92%	19932.84	1670 / 1809	97%	218.12	457 / 472
ovary	88%	20604.56	158 / 180	100%	209.51	429 / 430
kidney	84%	18101.30	75 / 89	99%	279.57	890 / 901
adrenal gland	82%	15126.30	211 / 258	97%	275.64	224 / 230
stomach	79%	39649.99	284 / 359	100%	337.93	286 / 286
pancreas	65%	11128.12	212 / 328	100%	359.55	178 / 178
brain	56%	10662.18	1483 / 2642	100%	256.28	704 / 705
tonsil	0%	0	0 / 0	100%	254.36	45 / 45
ureter	0%	0	0 / 0	100%	172.76	1 / 1
blood vessel	100%	192576.84	1334 / 1335	0%	0	0 / 0
liver	3%	410.40	7 / 226	95%	150.16	384 / 406
adipose	93%	25977.09	1114 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	91%	152.18	73 / 80
heart	85%	26105.07	733 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	59%	54.64	17 / 29
spleen	7%	1241.11	18 / 241	0%	0	0 / 0
muscle	4%	674.13	31 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0051014	Biological process	actin filament severing
GO_0048870	Biological process	cell motility
GO_0030836	Biological process	positive regulation of actin filament depolymerization
GO_0030043	Biological process	actin filament fragmentation
GO_0008154	Biological process	actin polymerization or depolymerization
GO_0030042	Biological process	actin filament depolymerization
GO_0015629	Cellular component	actin cytoskeleton
GO_0070062	Cellular component	extracellular exosome
GO_0030864	Cellular component	cortical actin cytoskeleton
GO_0005737	Cellular component	cytoplasm
GO_0051015	Molecular function	actin filament binding
GO_0005515	Molecular function	protein binding

Gene name	DSTN
Protein name	Destrin (Actin-depolymerizing factor) (ADF) Destrin (Actin-depolymerizing factor)
Synonyms	DSN ACTDP
Description	FUNCTION: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. . FUNCTION: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. .
Accessions	ENST00000474024.5 [P60981-2] F6RFD5 ENST00000449141.2 P60981 ENST00000246069.12 [P60981-1]

DSTN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review