DDX46 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	40 studies	30% ± 10%	Explore
natural killer cell	37 studies	33% ± 10%	Explore
B cell	35 studies	29% ± 8%	Explore
fibroblast	34 studies	26% ± 8%	Explore
T cell	32 studies	26% ± 7%	Explore
CD8-positive, alpha-beta T cell	31 studies	30% ± 10%	Explore
CD4-positive, alpha-beta T cell	30 studies	28% ± 9%	Explore
pericyte	28 studies	25% ± 7%	Explore
macrophage	26 studies	26% ± 8%	Explore
conventional dendritic cell	25 studies	26% ± 13%	Explore
smooth muscle cell	24 studies	27% ± 6%	Explore
classical monocyte	21 studies	29% ± 11%	Explore
regulatory T cell	21 studies	29% ± 6%	Explore
memory B cell	19 studies	26% ± 6%	Explore
naive B cell	19 studies	26% ± 6%	Explore
non-classical monocyte	18 studies	29% ± 12%	Explore
monocyte	17 studies	26% ± 7%	Explore
plasmacytoid dendritic cell	17 studies	29% ± 10%	Explore
mature NK T cell	17 studies	29% ± 7%	Explore
gamma-delta T cell	17 studies	35% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	28% ± 9%	Explore
epithelial cell	16 studies	34% ± 20%	Explore
mast cell	15 studies	22% ± 7%	Explore
endothelial cell of lymphatic vessel	15 studies	28% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	32% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	32% ± 9%	Explore
dendritic cell	14 studies	29% ± 16%	Explore
basal cell	14 studies	30% ± 15%	Explore
ciliated cell	14 studies	30% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	32% ± 9%	Explore
capillary endothelial cell	13 studies	24% ± 7%	Explore
mucosal invariant T cell	13 studies	28% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	32% ± 7%	Explore
connective tissue cell	12 studies	28% ± 9%	Explore
vein endothelial cell	12 studies	25% ± 8%	Explore
endothelial cell of vascular tree	12 studies	24% ± 6%	Explore
plasma cell	11 studies	27% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	28% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	32% ± 11%	Explore
myofibroblast cell	11 studies	30% ± 8%	Explore
oligodendrocyte	11 studies	31% ± 11%	Explore
microglial cell	11 studies	26% ± 8%	Explore
astrocyte	11 studies	33% ± 12%	Explore
glutamatergic neuron	10 studies	35% ± 21%	Explore
oligodendrocyte precursor cell	10 studies	31% ± 10%	Explore
type I pneumocyte	9 studies	27% ± 6%	Explore
type II pneumocyte	9 studies	25% ± 12%	Explore
abnormal cell	9 studies	29% ± 11%	Explore
myeloid cell	9 studies	29% ± 12%	Explore
plasmablast	8 studies	42% ± 20%	Explore
GABAergic neuron	8 studies	35% ± 17%	Explore
neuron	8 studies	36% ± 14%	Explore
endothelial cell of artery	8 studies	26% ± 4%	Explore
goblet cell	8 studies	28% ± 14%	Explore
adipocyte	8 studies	33% ± 8%	Explore
secretory cell	7 studies	27% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	35% ± 12%	Explore
progenitor cell	7 studies	25% ± 5%	Explore
retinal rod cell	7 studies	26% ± 9%	Explore
interneuron	7 studies	36% ± 21%	Explore
club cell	7 studies	24% ± 9%	Explore
T follicular helper cell	7 studies	24% ± 2%	Explore
hematopoietic precursor cell	6 studies	37% ± 16%	Explore
leukocyte	6 studies	32% ± 8%	Explore
mononuclear phagocyte	6 studies	27% ± 12%	Explore
mesothelial cell	6 studies	29% ± 11%	Explore
amacrine cell	6 studies	34% ± 14%	Explore
lymphocyte	6 studies	35% ± 10%	Explore
precursor B cell	6 studies	33% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	34% ± 8%	Explore
alveolar macrophage	5 studies	22% ± 6%	Explore
respiratory goblet cell	5 studies	26% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	32% ± 8%	Explore
transit amplifying cell	5 studies	34% ± 23%	Explore
hematopoietic stem cell	5 studies	29% ± 11%	Explore
pro-B cell	5 studies	33% ± 5%	Explore
brush cell	5 studies	26% ± 6%	Explore
retina horizontal cell	5 studies	33% ± 13%	Explore
Mueller cell	5 studies	24% ± 6%	Explore
innate lymphoid cell	5 studies	32% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	28% ± 6%	Explore
pancreatic A cell	4 studies	37% ± 13%	Explore
exhausted T cell	4 studies	40% ± 15%	Explore
retinal bipolar neuron	4 studies	32% ± 11%	Explore
glial cell	4 studies	27% ± 15%	Explore
retinal ganglion cell	4 studies	35% ± 14%	Explore
immature B cell	4 studies	29% ± 6%	Explore
retinal cone cell	4 studies	36% ± 14%	Explore
cardiac muscle cell	4 studies	18% ± 1%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	25% ± 7%	Explore
myoepithelial cell	4 studies	25% ± 7%	Explore
enteroendocrine cell	4 studies	32% ± 11%	Explore
T-helper 17 cell	4 studies	32% ± 7%	Explore
double negative thymocyte	4 studies	41% ± 14%	Explore
ionocyte	3 studies	28% ± 5%	Explore
type B pancreatic cell	3 studies	42% ± 6%	Explore
neural crest cell	3 studies	42% ± 3%	Explore
erythroblast	3 studies	47% ± 17%	Explore
rod bipolar cell	3 studies	26% ± 7%	Explore
germinal center B cell	3 studies	26% ± 3%	Explore
intermediate monocyte	3 studies	41% ± 21%	Explore
CD4-positive helper T cell	3 studies	31% ± 6%	Explore
muscle cell	3 studies	34% ± 11%	Explore
pancreatic ductal cell	3 studies	34% ± 12%	Explore
granulocyte	3 studies	19% ± 3%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	40% ± 19%	Explore
adventitial cell	3 studies	19% ± 3%	Explore
erythrocyte	3 studies	39% ± 17%	Explore
group 3 innate lymphoid cell	3 studies	39% ± 14%	Explore
hepatocyte	3 studies	48% ± 15%	Explore
T-helper 1 cell	3 studies	30% ± 1%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	31% ± 1%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	32% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	27% ± 9%	Explore
brain	17 studies	30% ± 15%	Explore
peripheral blood	16 studies	32% ± 10%	Explore
intestine	9 studies	24% ± 10%	Explore
eye	8 studies	30% ± 11%	Explore
kidney	6 studies	24% ± 5%	Explore
lymph node	5 studies	29% ± 12%	Explore
liver	5 studies	39% ± 18%	Explore
bone marrow	4 studies	27% ± 5%	Explore
heart	4 studies	21% ± 3%	Explore
uterus	4 studies	30% ± 16%	Explore
adipose	4 studies	34% ± 9%	Explore
pancreas	3 studies	43% ± 6%	Explore
placenta	3 studies	20% ± 2%	Explore
breast	3 studies	23% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3708.65	1445 / 1445	100%	34.80	183 / 183
intestine	100%	4174.06	966 / 966	100%	26.38	527 / 527
lung	100%	3982.64	578 / 578	100%	24.42	1155 / 1155
ovary	100%	4112.43	180 / 180	100%	23.40	430 / 430
uterus	100%	4716.85	170 / 170	100%	27.48	459 / 459
breast	100%	4337.83	459 / 459	100%	33.35	1117 / 1118
bladder	100%	3868.90	21 / 21	100%	22.49	502 / 504
prostate	100%	3582.01	245 / 245	100%	21.86	500 / 502
pancreas	100%	2497.54	328 / 328	99%	21.46	177 / 178
stomach	100%	3245.83	359 / 359	99%	27.76	284 / 286
thymus	100%	4078.25	653 / 653	99%	20.97	598 / 605
brain	99%	2405.81	2606 / 2642	100%	23.23	705 / 705
skin	100%	4904.53	1809 / 1809	97%	22.97	459 / 472
kidney	100%	2757.29	89 / 89	97%	17.95	874 / 901
liver	100%	2133.23	226 / 226	97%	13.15	392 / 406
adrenal gland	100%	3521.87	258 / 258	96%	14.99	220 / 230
adipose	100%	4053.59	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3899.12	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	28.47	29 / 29
muscle	100%	4655.24	803 / 803	0%	0	0 / 0
spleen	100%	4784.88	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	30.87	45 / 45
heart	97%	2163.58	834 / 861	0%	0	0 / 0
peripheral blood	94%	3029.96	872 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	90%	11.62	72 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_1903241	Biological process	U2-type prespliceosome assembly
GO_0005686	Cellular component	U2 snRNP
GO_0015030	Cellular component	Cajal body
GO_0016607	Cellular component	nuclear speck
GO_0001650	Cellular component	fibrillar center
GO_0005654	Cellular component	nucleoplasm
GO_0005681	Cellular component	spliceosomal complex
GO_0005684	Cellular component	U2-type spliceosomal complex
GO_0005634	Cellular component	nucleus
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0003724	Molecular function	RNA helicase activity
GO_0016887	Molecular function	ATP hydrolysis activity
GO_0005524	Molecular function	ATP binding

IV. Literature review

[source]

Gene name	DDX46
Protein name	DEAD-box helicase 46 RNA helicase (EC 3.6.4.13) ATP-dependent RNA helicase (EC 3.6.4.13) DDX46 protein Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog)
Synonyms	KIAA0801 hCG_16595
Description	FUNCTION: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs . The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing . Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site . . FUNCTION: RNA helicase. .
Accessions	A0A0C4DG89 H0YAD5 D6RJA6 H0Y9U3 ENST00000513592.5 Q0VGL8 ENST00000507392.5 ENST00000354283.8 ENST00000452510.7 ENST00000628477.2 Q7L014 ENST00000507053.1

DDX46 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review