DDX46 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_1903241Biological processU2-type prespliceosome assembly
GO_0005686Cellular componentU2 snRNP
GO_0015030Cellular componentCajal body
GO_0016607Cellular componentnuclear speck
GO_0001650Cellular componentfibrillar center
GO_0005654Cellular componentnucleoplasm
GO_0005681Cellular componentspliceosomal complex
GO_0005684Cellular componentU2-type spliceosomal complex
GO_0005634Cellular componentnucleus
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0003724Molecular functionRNA helicase activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameDDX46
Protein nameDEAD-box helicase 46
RNA helicase (EC 3.6.4.13)
ATP-dependent RNA helicase (EC 3.6.4.13)
DDX46 protein
Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog)
SynonymsKIAA0801
hCG_16595
DescriptionFUNCTION: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs . The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing . Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site . .

FUNCTION: RNA helicase. .

AccessionsA0A0C4DG89
H0YAD5
D6RJA6
H0Y9U3
ENST00000513592.5
Q0VGL8
ENST00000507392.5
ENST00000354283.8
ENST00000452510.7
ENST00000628477.2
Q7L014
ENST00000507053.1