CDC37 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	45 studies	48% ± 20%	Explore
B cell	36 studies	32% ± 11%	Explore
fibroblast	34 studies	28% ± 12%	Explore
natural killer cell	33 studies	39% ± 13%	Explore
CD8-positive, alpha-beta T cell	32 studies	39% ± 18%	Explore
macrophage	30 studies	35% ± 12%	Explore
CD4-positive, alpha-beta T cell	30 studies	38% ± 16%	Explore
T cell	29 studies	35% ± 11%	Explore
pericyte	28 studies	33% ± 15%	Explore
conventional dendritic cell	26 studies	43% ± 17%	Explore
regulatory T cell	24 studies	45% ± 15%	Explore
smooth muscle cell	23 studies	28% ± 10%	Explore
classical monocyte	23 studies	37% ± 12%	Explore
dendritic cell	22 studies	41% ± 23%	Explore
endothelial cell of lymphatic vessel	22 studies	48% ± 18%	Explore
non-classical monocyte	21 studies	39% ± 14%	Explore
plasmacytoid dendritic cell	20 studies	40% ± 14%	Explore
monocyte	19 studies	34% ± 11%	Explore
mature NK T cell	19 studies	35% ± 13%	Explore
memory B cell	19 studies	37% ± 10%	Explore
naive B cell	18 studies	34% ± 10%	Explore
gamma-delta T cell	17 studies	41% ± 15%	Explore
epithelial cell	17 studies	37% ± 20%	Explore
capillary endothelial cell	16 studies	48% ± 18%	Explore
mast cell	15 studies	29% ± 7%	Explore
mucosal invariant T cell	15 studies	40% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	33% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	43% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	42% ± 12%	Explore
basal cell	14 studies	37% ± 18%	Explore
endothelial cell of artery	14 studies	54% ± 22%	Explore
myofibroblast cell	14 studies	34% ± 12%	Explore
endothelial cell of vascular tree	14 studies	52% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	40% ± 10%	Explore
connective tissue cell	13 studies	34% ± 11%	Explore
myeloid cell	13 studies	33% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	43% ± 13%	Explore
ciliated cell	12 studies	34% ± 14%	Explore
vein endothelial cell	12 studies	60% ± 14%	Explore
plasma cell	11 studies	37% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	43% ± 15%	Explore
type I pneumocyte	9 studies	29% ± 13%	Explore
plasmablast	9 studies	48% ± 21%	Explore
secretory cell	9 studies	33% ± 19%	Explore
platelet	9 studies	27% ± 8%	Explore
leukocyte	9 studies	29% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	42% ± 12%	Explore
goblet cell	9 studies	30% ± 10%	Explore
abnormal cell	9 studies	35% ± 15%	Explore
alveolar macrophage	8 studies	31% ± 10%	Explore
innate lymphoid cell	8 studies	37% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	51% ± 19%	Explore
neuron	7 studies	36% ± 15%	Explore
hematopoietic stem cell	7 studies	40% ± 14%	Explore
T follicular helper cell	7 studies	35% ± 11%	Explore
hematopoietic precursor cell	6 studies	38% ± 21%	Explore
club cell	6 studies	30% ± 11%	Explore
respiratory goblet cell	6 studies	30% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	52% ± 19%	Explore
mononuclear phagocyte	6 studies	34% ± 14%	Explore
progenitor cell	6 studies	29% ± 12%	Explore
transit amplifying cell	6 studies	24% ± 6%	Explore
glutamatergic neuron	6 studies	32% ± 17%	Explore
precursor B cell	6 studies	47% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	47% ± 17%	Explore
oligodendrocyte precursor cell	6 studies	22% ± 5%	Explore
CD4-positive helper T cell	5 studies	28% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	37% ± 14%	Explore
exhausted T cell	5 studies	53% ± 9%	Explore
mesothelial cell	5 studies	39% ± 16%	Explore
lymphocyte	5 studies	36% ± 16%	Explore
pro-B cell	5 studies	41% ± 11%	Explore
T-helper 17 cell	5 studies	47% ± 20%	Explore
immature B cell	5 studies	40% ± 15%	Explore
type II pneumocyte	5 studies	35% ± 16%	Explore
astrocyte	5 studies	29% ± 7%	Explore
microglial cell	5 studies	26% ± 8%	Explore
erythrocyte	5 studies	37% ± 16%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	35% ± 17%	Explore
squamous epithelial cell	4 studies	32% ± 24%	Explore
glomerular endothelial cell	4 studies	43% ± 10%	Explore
retinal ganglion cell	4 studies	65% ± 25%	Explore
erythroblast	4 studies	34% ± 19%	Explore
amacrine cell	4 studies	30% ± 10%	Explore
retinal rod cell	4 studies	20% ± 4%	Explore
cardiac muscle cell	4 studies	18% ± 2%	Explore
intermediate monocyte	4 studies	50% ± 16%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	25% ± 5%	Explore
granulocyte	4 studies	28% ± 7%	Explore
GABAergic neuron	4 studies	26% ± 11%	Explore
enteroendocrine cell	4 studies	38% ± 18%	Explore
keratinocyte	4 studies	19% ± 3%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	48% ± 23%	Explore
precursor cell	3 studies	54% ± 6%	Explore
pancreatic A cell	3 studies	28% ± 6%	Explore
monocyte-derived dendritic cell	3 studies	42% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	30% ± 9%	Explore
intestinal crypt stem cell	3 studies	21% ± 6%	Explore
neural crest cell	3 studies	30% ± 5%	Explore
retinal bipolar neuron	3 studies	30% ± 9%	Explore
extravillous trophoblast	3 studies	63% ± 7%	Explore
placental villous trophoblast	3 studies	40% ± 4%	Explore
megakaryocyte	3 studies	30% ± 9%	Explore
retina horizontal cell	3 studies	34% ± 12%	Explore
retinal cone cell	3 studies	37% ± 9%	Explore
tissue-resident macrophage	3 studies	26% ± 7%	Explore
intraepithelial lymphocyte	3 studies	35% ± 15%	Explore
germinal center B cell	3 studies	38% ± 11%	Explore
adipocyte	3 studies	18% ± 2%	Explore
endothelial cell of sinusoid	3 studies	32% ± 21%	Explore
muscle cell	3 studies	35% ± 13%	Explore
brush cell	3 studies	20% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	50% ± 8%	Explore
interneuron	3 studies	27% ± 12%	Explore
T-helper 1 cell	3 studies	58% ± 19%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	41% ± 16%	Explore
double negative thymocyte	3 studies	57% ± 6%	Explore
progenitor cell of mammary luminal epithelium	3 studies	27% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	39% ± 11%	Explore
lung	17 studies	36% ± 13%	Explore
intestine	10 studies	26% ± 12%	Explore
brain	9 studies	26% ± 10%	Explore
eye	7 studies	25% ± 6%	Explore
kidney	6 studies	33% ± 12%	Explore
lymph node	5 studies	36% ± 11%	Explore
bone marrow	4 studies	28% ± 11%	Explore
uterus	4 studies	38% ± 13%	Explore
breast	4 studies	33% ± 4%	Explore
liver	4 studies	37% ± 16%	Explore
pancreas	3 studies	30% ± 3%	Explore
placenta	3 studies	44% ± 9%	Explore
prostate	3 studies	20% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	10631.67	1445 / 1445	100%	124.41	183 / 183
liver	100%	5601.52	226 / 226	100%	116.74	406 / 406
skin	100%	10965.94	1809 / 1809	100%	220.63	472 / 472
thymus	100%	12836.50	653 / 653	100%	180.90	605 / 605
uterus	100%	12860.66	170 / 170	100%	211.05	459 / 459
ovary	100%	10941.16	180 / 180	100%	149.62	429 / 430
pancreas	100%	5554.60	327 / 328	100%	187.41	178 / 178
kidney	100%	10757.36	89 / 89	100%	143.69	898 / 901
stomach	100%	8287.62	359 / 359	100%	175.28	285 / 286
intestine	100%	11119.13	966 / 966	100%	208.29	525 / 527
adrenal gland	100%	8841.77	258 / 258	100%	157.48	229 / 230
brain	100%	7903.45	2629 / 2642	100%	144.94	705 / 705
lung	100%	15343.19	578 / 578	99%	145.25	1147 / 1155
prostate	100%	13037.93	245 / 245	99%	171.59	498 / 502
bladder	100%	11576.29	21 / 21	99%	204.88	499 / 504
breast	100%	14480.70	459 / 459	99%	152.36	1105 / 1118
adipose	100%	14534.13	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	214.59	80 / 80
lymph node	0%	0	0 / 0	100%	247.30	29 / 29
muscle	100%	12154.59	803 / 803	0%	0	0 / 0
spleen	100%	16427.48	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	185.33	45 / 45
ureter	0%	0	0 / 0	100%	186.81	1 / 1
blood vessel	100%	9622.30	1334 / 1335	0%	0	0 / 0
heart	100%	9892.43	860 / 861	0%	0	0 / 0
peripheral blood	99%	8236.77	918 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0060334	Biological process	regulation of type II interferon-mediated signaling pathway
GO_0098779	Biological process	positive regulation of mitophagy in response to mitochondrial depolarization
GO_0060338	Biological process	regulation of type I interferon-mediated signaling pathway
GO_0000079	Biological process	regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0010608	Biological process	post-transcriptional regulation of gene expression
GO_0006605	Biological process	protein targeting
GO_0006457	Biological process	protein folding
GO_0050821	Biological process	protein stabilization
GO_0070062	Cellular component	extracellular exosome
GO_0101031	Cellular component	protein folding chaperone complex
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_1990565	Cellular component	HSP90-CDC37 chaperone complex
GO_0051879	Molecular function	Hsp90 protein binding
GO_0019887	Molecular function	protein kinase regulator activity
GO_0019900	Molecular function	kinase binding
GO_0031072	Molecular function	heat shock protein binding
GO_0019901	Molecular function	protein kinase binding
GO_0051082	Molecular function	unfolded protein binding
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0097110	Molecular function	scaffold protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CDC37
Protein name	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] Hsp90 co-chaperone Cdc37 (p50Cdc37) Cell division cycle 37, HSP90 cochaperone Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Synonyms	CDC37A
Description	FUNCTION: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity . Inhibits HSP90AA1 ATPase activity . . FUNCTION: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. . FUNCTION: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. . FUNCTION: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. .
Accessions	Q16543 ENST00000593124.1 ENST00000589331.1 K7EQA9 K7EIU0 ENST00000588869.1 ENST00000589625.5 ENST00000222005.7 K7EKQ2 Q6FG59 K7EL68 K7EJ06 ENST00000589629.5

CDC37 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review