CAPZA1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	39 studies	38% ± 13%	Explore
B cell	37 studies	33% ± 11%	Explore
natural killer cell	36 studies	31% ± 7%	Explore
T cell	34 studies	31% ± 10%	Explore
CD8-positive, alpha-beta T cell	34 studies	31% ± 10%	Explore
endothelial cell	32 studies	28% ± 12%	Explore
CD4-positive, alpha-beta T cell	31 studies	30% ± 11%	Explore
conventional dendritic cell	27 studies	41% ± 15%	Explore
fibroblast	26 studies	25% ± 8%	Explore
classical monocyte	24 studies	39% ± 13%	Explore
non-classical monocyte	23 studies	47% ± 14%	Explore
regulatory T cell	23 studies	35% ± 8%	Explore
mast cell	21 studies	24% ± 10%	Explore
monocyte	21 studies	41% ± 13%	Explore
memory B cell	20 studies	32% ± 7%	Explore
dendritic cell	19 studies	37% ± 20%	Explore
naive B cell	19 studies	29% ± 7%	Explore
mature NK T cell	18 studies	30% ± 7%	Explore
endothelial cell of lymphatic vessel	17 studies	25% ± 8%	Explore
plasmacytoid dendritic cell	17 studies	32% ± 11%	Explore
pericyte	17 studies	26% ± 10%	Explore
gamma-delta T cell	17 studies	35% ± 12%	Explore
myeloid cell	17 studies	40% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	30% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	25% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	28% ± 7%	Explore
plasma cell	14 studies	30% ± 13%	Explore
smooth muscle cell	14 studies	21% ± 4%	Explore
mucosal invariant T cell	14 studies	28% ± 6%	Explore
epithelial cell	13 studies	38% ± 22%	Explore
microglial cell	13 studies	32% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	35% ± 10%	Explore
astrocyte	12 studies	33% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	33% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	29% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	31% ± 9%	Explore
neutrophil	10 studies	33% ± 8%	Explore
leukocyte	10 studies	34% ± 11%	Explore
connective tissue cell	10 studies	26% ± 7%	Explore
capillary endothelial cell	10 studies	19% ± 2%	Explore
basal cell	10 studies	36% ± 22%	Explore
plasmablast	9 studies	37% ± 21%	Explore
myofibroblast cell	9 studies	21% ± 4%	Explore
adipocyte	9 studies	22% ± 7%	Explore
oligodendrocyte	9 studies	29% ± 11%	Explore
alveolar macrophage	8 studies	37% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	35% ± 14%	Explore
vein endothelial cell	8 studies	23% ± 11%	Explore
T follicular helper cell	8 studies	31% ± 7%	Explore
ciliated cell	8 studies	40% ± 16%	Explore
mononuclear phagocyte	7 studies	44% ± 13%	Explore
endothelial cell of artery	7 studies	20% ± 4%	Explore
hematopoietic precursor cell	6 studies	41% ± 14%	Explore
platelet	6 studies	21% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	38% ± 11%	Explore
neuron	6 studies	33% ± 15%	Explore
goblet cell	6 studies	33% ± 19%	Explore
hematopoietic stem cell	6 studies	22% ± 9%	Explore
lymphocyte	6 studies	39% ± 17%	Explore
precursor B cell	6 studies	33% ± 11%	Explore
innate lymphoid cell	6 studies	28% ± 8%	Explore
club cell	6 studies	26% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	35% ± 11%	Explore
endothelial cell of vascular tree	6 studies	26% ± 12%	Explore
type I pneumocyte	6 studies	26% ± 8%	Explore
GABAergic neuron	6 studies	39% ± 17%	Explore
oligodendrocyte precursor cell	6 studies	29% ± 11%	Explore
transit amplifying cell	5 studies	30% ± 20%	Explore
glutamatergic neuron	5 studies	51% ± 20%	Explore
pro-B cell	5 studies	29% ± 6%	Explore
mesothelial cell	5 studies	30% ± 15%	Explore
secretory cell	5 studies	30% ± 18%	Explore
type II pneumocyte	5 studies	27% ± 9%	Explore
abnormal cell	5 studies	29% ± 6%	Explore
interneuron	5 studies	35% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	32% ± 8%	Explore
exhausted T cell	4 studies	46% ± 14%	Explore
progenitor cell	4 studies	30% ± 15%	Explore
immature B cell	4 studies	30% ± 7%	Explore
cardiac muscle cell	4 studies	21% ± 2%	Explore
Mueller cell	4 studies	22% ± 3%	Explore
respiratory goblet cell	4 studies	30% ± 19%	Explore
germinal center B cell	4 studies	41% ± 14%	Explore
granulocyte	4 studies	31% ± 14%	Explore
enteroendocrine cell	4 studies	25% ± 10%	Explore
keratinocyte	4 studies	27% ± 10%	Explore
T-helper 17 cell	4 studies	41% ± 9%	Explore
double negative thymocyte	4 studies	42% ± 10%	Explore
pancreatic A cell	3 studies	34% ± 12%	Explore
glomerular endothelial cell	3 studies	17% ± 0%	Explore
neural crest cell	3 studies	20% ± 1%	Explore
extravillous trophoblast	3 studies	36% ± 3%	Explore
placental villous trophoblast	3 studies	29% ± 0%	Explore
erythroblast	3 studies	47% ± 19%	Explore
megakaryocyte	3 studies	33% ± 9%	Explore
squamous epithelial cell	3 studies	45% ± 25%	Explore
brush cell	3 studies	31% ± 7%	Explore
retinal rod cell	3 studies	17% ± 3%	Explore
tissue-resident macrophage	3 studies	42% ± 7%	Explore
rod bipolar cell	3 studies	17% ± 1%	Explore
intermediate monocyte	3 studies	50% ± 22%	Explore
CD4-positive helper T cell	3 studies	34% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	20% ± 3%	Explore
inflammatory macrophage	3 studies	35% ± 2%	Explore
muscle cell	3 studies	29% ± 11%	Explore
group 3 innate lymphoid cell	3 studies	31% ± 12%	Explore
T-helper 1 cell	3 studies	40% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	29% ± 8%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	28% ± 9%	Explore
erythrocyte	3 studies	29% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	30% ± 15%	Explore
peripheral blood	17 studies	35% ± 11%	Explore
brain	13 studies	32% ± 17%	Explore
intestine	9 studies	24% ± 11%	Explore
kidney	5 studies	22% ± 4%	Explore
heart	5 studies	21% ± 2%	Explore
liver	5 studies	37% ± 18%	Explore
bone marrow	4 studies	30% ± 8%	Explore
eye	4 studies	28% ± 14%	Explore
uterus	4 studies	32% ± 14%	Explore
lymph node	4 studies	27% ± 4%	Explore
adipose	4 studies	25% ± 5%	Explore
placenta	3 studies	38% ± 8%	Explore
breast	3 studies	17% ± 0%	Explore
esophagus	3 studies	34% ± 21%	Explore
skin	3 studies	21% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	4952.14	21 / 21	100%	179.75	504 / 504
breast	100%	5416.15	459 / 459	100%	191.81	1118 / 1118
ovary	100%	3715.49	180 / 180	100%	133.01	430 / 430
prostate	100%	4922.82	245 / 245	100%	110.61	502 / 502
esophagus	100%	6984.00	1444 / 1445	100%	160.29	183 / 183
lung	100%	8176.47	578 / 578	100%	178.63	1154 / 1155
intestine	100%	5873.79	966 / 966	100%	166.09	526 / 527
stomach	100%	4151.06	359 / 359	100%	151.68	285 / 286
uterus	100%	4400.56	170 / 170	99%	189.40	456 / 459
thymus	100%	5307.84	653 / 653	99%	125.31	601 / 605
skin	100%	9871.04	1809 / 1809	99%	155.40	465 / 472
kidney	100%	4096.19	89 / 89	97%	105.81	878 / 901
brain	99%	3336.63	2605 / 2642	99%	80.74	696 / 705
pancreas	99%	2997.37	325 / 328	98%	140.44	174 / 178
liver	100%	3629.29	226 / 226	95%	68.58	386 / 406
adrenal gland	100%	5449.41	258 / 258	92%	52.91	212 / 230
lymph node	0%	0	0 / 0	100%	234.44	29 / 29
spleen	100%	11377.49	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	200.14	45 / 45
ureter	0%	0	0 / 0	100%	92.19	1 / 1
adipose	100%	6184.35	1203 / 1204	0%	0	0 / 0
peripheral blood	99%	15475.02	923 / 929	0%	0	0 / 0
blood vessel	99%	4102.39	1326 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	187.54	79 / 80
heart	91%	2353.56	785 / 861	0%	0	0 / 0
muscle	86%	2130.02	693 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030036	Biological process	actin cytoskeleton organization
GO_0051016	Biological process	barbed-end actin filament capping
GO_0065003	Biological process	protein-containing complex assembly
GO_0034329	Biological process	cell junction assembly
GO_0008290	Cellular component	F-actin capping protein complex
GO_0030863	Cellular component	cortical cytoskeleton
GO_0015629	Cellular component	actin cytoskeleton
GO_0070062	Cellular component	extracellular exosome
GO_0005856	Cellular component	cytoskeleton
GO_0071203	Cellular component	WASH complex
GO_0005829	Cellular component	cytosol
GO_0005576	Cellular component	extracellular region
GO_0045296	Molecular function	cadherin binding
GO_0051015	Molecular function	actin filament binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding

IV. Literature review

[source]

Gene name	CAPZA1
Protein name	F-actin-capping protein subunit alpha-1 (CapZ alpha-1)
Synonyms
Description	FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions . Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). .
Accessions	ENST00000263168.4 P52907

CAPZA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review