BRD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071168Biological processprotein localization to chromatin
GO_2000330Biological processpositive regulation of T-helper 17 cell lineage commitment
GO_0007283Biological processspermatogenesis
GO_0001843Biological processneural tube closure
GO_0140588Biological processchromatin looping
GO_0006334Biological processnucleosome assembly
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0070577Molecular functionlysine-acetylated histone binding
GO_0140033Molecular functionacetylation-dependent protein binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameBRD2
Protein nameBromodomain-containing protein 2 (O27.1.1)
Bromodomain containing 2 (Bromodomain-containing protein 2)
Bromodomain containing 2
Bromodomain-containing protein 2
SynonymsKIAA9001
RING3
DescriptionFUNCTION: Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures . Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation . Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation . Also recognizes and binds acetylated non-histone proteins, such as STAT3 . Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin . In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation . Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) . .

AccessionsENST00000452539.5
ENST00000429833.5
ENST00000456339.5
ENST00000481259.1
ENST00000414731.6
ENST00000446150.3
ENST00000450320.5
ENST00000607833.5
ENST00000454038.5
ENST00000425016.5
ENST00000549126.4 [P25440-1]
H0Y799
ENST00000433783.5
ENST00000496118.2
A0A0G2JK44
ENST00000677085.1
ENST00000477259.5
A0A140T9X8
ENST00000678778.1
ENST00000442863.5 [P25440-2]
X5CF57
ENST00000552587.4 [P25440-1]
ENST00000449118.5
A0A0G2JHN8
H0Y6K2
ENST00000493063.5
ENST00000374831.8 [P25440-1]
ENST00000383108.6 [P25440-1]
ENST00000518754.1
ENST00000442219.5
ENST00000425201.5
ENST00000457933.1
J3QR72
ENST00000399527.5 [P25440-2]
A0A140T9I1
ENST00000427021.3
ENST00000438194.6 [P25440-1]
A0A140T9V2
E9PKQ9
ENST00000679179.1
E9PIQ3
ENST00000450284.5
ENST00000479699.5
A0A140T9F7
A0A140T9E9
ENST00000424160.5
H0YDJ7
U3KQA6
ENST00000412535.5
ENST00000395287.5 [P25440-2]
ENST00000399529.7 [P25440-1]
ENST00000495733.5
ENST00000439194.3
ENST00000436979.5 [P25440-3]
ENST00000416727.5
ENST00000492172.5
ENST00000606059.1
U3KPW0
ENST00000448067.5 [P25440-2]
A0A0G2JHL0
ENST00000496177.1
ENST00000449025.5
ENST00000486864.5
ENST00000374825.9 [P25440-1]
ENST00000477920.5
ENST00000399528.5 [P25440-1]
ENST00000449085.4 [P25440-1]
ENST00000678250.1 [P25440-1]
ENST00000482914.5
P25440
ENST00000447730.5