ATP1A1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	49 studies	38% ± 15%	Explore
fibroblast	35 studies	30% ± 13%	Explore
macrophage	32 studies	25% ± 8%	Explore
CD4-positive, alpha-beta T cell	27 studies	27% ± 8%	Explore
T cell	26 studies	28% ± 12%	Explore
basal cell	23 studies	50% ± 15%	Explore
CD8-positive, alpha-beta T cell	23 studies	24% ± 6%	Explore
conventional dendritic cell	23 studies	30% ± 11%	Explore
classical monocyte	21 studies	29% ± 11%	Explore
epithelial cell	20 studies	47% ± 20%	Explore
non-classical monocyte	20 studies	37% ± 14%	Explore
ciliated cell	19 studies	48% ± 17%	Explore
regulatory T cell	18 studies	23% ± 6%	Explore
B cell	17 studies	19% ± 4%	Explore
monocyte	17 studies	29% ± 11%	Explore
pericyte	16 studies	28% ± 10%	Explore
natural killer cell	15 studies	22% ± 5%	Explore
smooth muscle cell	14 studies	26% ± 8%	Explore
dendritic cell	13 studies	32% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	31% ± 9%	Explore
oligodendrocyte precursor cell	13 studies	32% ± 18%	Explore
capillary endothelial cell	13 studies	32% ± 13%	Explore
endothelial cell of artery	13 studies	46% ± 19%	Explore
gamma-delta T cell	13 studies	27% ± 9%	Explore
endothelial cell of vascular tree	13 studies	54% ± 21%	Explore
type I pneumocyte	12 studies	60% ± 19%	Explore
type II pneumocyte	12 studies	64% ± 19%	Explore
secretory cell	12 studies	45% ± 14%	Explore
endothelial cell of lymphatic vessel	11 studies	23% ± 8%	Explore
club cell	11 studies	53% ± 16%	Explore
glutamatergic neuron	11 studies	43% ± 21%	Explore
vein endothelial cell	11 studies	45% ± 20%	Explore
oligodendrocyte	11 studies	25% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	28% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	28% ± 9%	Explore
mature NK T cell	10 studies	21% ± 4%	Explore
mucosal invariant T cell	10 studies	25% ± 6%	Explore
myeloid cell	10 studies	31% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	29% ± 9%	Explore
epithelial cell of proximal tubule	9 studies	30% ± 7%	Explore
connective tissue cell	9 studies	27% ± 10%	Explore
goblet cell	9 studies	46% ± 15%	Explore
mesothelial cell	9 studies	31% ± 12%	Explore
memory B cell	9 studies	21% ± 4%	Explore
respiratory goblet cell	8 studies	53% ± 17%	Explore
GABAergic neuron	8 studies	40% ± 21%	Explore
kidney loop of Henle epithelial cell	8 studies	78% ± 12%	Explore
renal alpha-intercalated cell	8 studies	62% ± 23%	Explore
abnormal cell	8 studies	32% ± 8%	Explore
enterocyte	8 studies	57% ± 24%	Explore
retinal cone cell	8 studies	54% ± 14%	Explore
microglial cell	8 studies	29% ± 14%	Explore
leukocyte	7 studies	26% ± 5%	Explore
progenitor cell	7 studies	45% ± 18%	Explore
kidney distal convoluted tubule epithelial cell	7 studies	69% ± 27%	Explore
retinal rod cell	7 studies	24% ± 7%	Explore
T follicular helper cell	7 studies	24% ± 8%	Explore
ionocyte	6 studies	82% ± 10%	Explore
mononuclear phagocyte	6 studies	31% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	19% ± 2%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	20% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	28% ± 8%	Explore
neuron	6 studies	34% ± 14%	Explore
amacrine cell	6 studies	48% ± 18%	Explore
plasmacytoid dendritic cell	6 studies	21% ± 7%	Explore
innate lymphoid cell	6 studies	27% ± 11%	Explore
mucus secreting cell	6 studies	35% ± 9%	Explore
alveolar macrophage	5 studies	19% ± 5%	Explore
astrocyte	5 studies	23% ± 6%	Explore
hematopoietic precursor cell	5 studies	25% ± 4%	Explore
kidney connecting tubule epithelial cell	5 studies	83% ± 21%	Explore
transit amplifying cell	5 studies	59% ± 20%	Explore
retinal ganglion cell	5 studies	70% ± 22%	Explore
renal principal cell	5 studies	58% ± 28%	Explore
neuroendocrine cell	5 studies	58% ± 28%	Explore
cardiac muscle cell	5 studies	22% ± 1%	Explore
Mueller cell	5 studies	53% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	33% ± 11%	Explore
interneuron	5 studies	45% ± 22%	Explore
deuterosomal cell	4 studies	33% ± 11%	Explore
duct epithelial cell	4 studies	62% ± 26%	Explore
pancreatic A cell	4 studies	43% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	23% ± 6%	Explore
enteroendocrine cell	4 studies	39% ± 10%	Explore
intestinal crypt stem cell	4 studies	55% ± 15%	Explore
lymphocyte	4 studies	30% ± 8%	Explore
brush cell	4 studies	38% ± 10%	Explore
retina horizontal cell	4 studies	30% ± 7%	Explore
retinal pigment epithelial cell	4 studies	58% ± 20%	Explore
adventitial cell	4 studies	35% ± 11%	Explore
erythroblast	4 studies	27% ± 10%	Explore
CD4-positive helper T cell	4 studies	27% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	49% ± 5%	Explore
luminal cell of prostate epithelium	4 studies	53% ± 6%	Explore
keratinocyte	4 studies	33% ± 9%	Explore
T-helper 17 cell	4 studies	27% ± 9%	Explore
mast cell	3 studies	19% ± 2%	Explore
hillock cell	3 studies	62% ± 18%	Explore
squamous epithelial cell	3 studies	45% ± 22%	Explore
pancreatic D cell	3 studies	43% ± 22%	Explore
type B pancreatic cell	3 studies	48% ± 16%	Explore
exhausted T cell	3 studies	22% ± 4%	Explore
myofibroblast cell	3 studies	21% ± 4%	Explore
podocyte	3 studies	57% ± 10%	Explore
retinal bipolar neuron	3 studies	23% ± 5%	Explore
GABAergic interneuron	3 studies	24% ± 7%	Explore
GABAergic amacrine cell	3 studies	35% ± 13%	Explore
glycinergic amacrine cell	3 studies	35% ± 13%	Explore
megakaryocyte	3 studies	21% ± 7%	Explore
serous secreting cell	3 studies	43% ± 19%	Explore
OFF-bipolar cell	3 studies	33% ± 15%	Explore
ON-bipolar cell	3 studies	41% ± 29%	Explore
muscle cell	3 studies	34% ± 2%	Explore
pancreatic ductal cell	3 studies	87% ± 6%	Explore
granulocyte	3 studies	19% ± 2%	Explore
hepatocyte	3 studies	50% ± 28%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 9%	Explore
melanocyte	3 studies	55% ± 23%	Explore
T-helper 1 cell	3 studies	32% ± 10%	Explore
progenitor cell of mammary luminal epithelium	3 studies	46% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	36% ± 10%	Explore
brain	17 studies	33% ± 17%	Explore
peripheral blood	12 studies	27% ± 7%	Explore
intestine	11 studies	30% ± 17%	Explore
kidney	11 studies	38% ± 13%	Explore
eye	10 studies	37% ± 13%	Explore
uterus	5 studies	32% ± 14%	Explore
prostate	5 studies	39% ± 7%	Explore
liver	5 studies	30% ± 11%	Explore
pancreas	4 studies	45% ± 18%	Explore
placenta	4 studies	20% ± 2%	Explore
bone marrow	4 studies	21% ± 5%	Explore
heart	4 studies	18% ± 2%	Explore
lymph node	4 studies	30% ± 8%	Explore
breast	4 studies	40% ± 11%	Explore
esophagus	3 studies	38% ± 13%	Explore
thymus	3 studies	25% ± 7%	Explore
skin	3 studies	24% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	100%	39928.44	1809 / 1809	99%	414.47	466 / 472
stomach	99%	21658.48	356 / 359	99%	180.00	283 / 286
intestine	98%	56515.36	947 / 966	98%	201.47	517 / 527
pancreas	100%	35303.65	328 / 328	96%	146.53	171 / 178
lung	100%	39947.87	576 / 578	96%	124.46	1110 / 1155
esophagus	98%	21862.37	1416 / 1445	97%	162.91	177 / 183
breast	100%	23613.52	457 / 459	93%	105.30	1035 / 1118
thymus	100%	76286.51	653 / 653	89%	170.19	537 / 605
prostate	100%	22679.49	244 / 245	88%	97.79	443 / 502
ovary	99%	16958.32	179 / 180	87%	82.03	375 / 430
kidney	100%	81890.63	89 / 89	85%	115.14	765 / 901
uterus	99%	13693.32	169 / 170	85%	91.21	390 / 459
bladder	100%	14519.48	21 / 21	82%	106.07	411 / 504
brain	91%	29744.46	2414 / 2642	87%	61.33	615 / 705
adrenal gland	98%	19473.69	252 / 258	73%	98.67	167 / 230
liver	50%	6897.28	112 / 226	58%	70.48	234 / 406
adipose	100%	20544.38	1199 / 1204	0%	0	0 / 0
blood vessel	99%	18836.01	1317 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	98%	199.09	78 / 80
spleen	96%	9935.95	231 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	170.31	43 / 45
heart	92%	19883.23	790 / 861	0%	0	0 / 0
peripheral blood	63%	12676.16	583 / 929	0%	0	0 / 0
muscle	57%	11244.46	459 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	52%	33.85	15 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0002028	Biological process	regulation of sodium ion transport
GO_0086002	Biological process	cardiac muscle cell action potential involved in contraction
GO_0036376	Biological process	sodium ion export across plasma membrane
GO_0086064	Biological process	cell communication by electrical coupling involved in cardiac conduction
GO_0008217	Biological process	regulation of blood pressure
GO_0071383	Biological process	cellular response to steroid hormone stimulus
GO_0002026	Biological process	regulation of the force of heart contraction
GO_0045989	Biological process	positive regulation of striated muscle contraction
GO_0006883	Biological process	intracellular sodium ion homeostasis
GO_0055119	Biological process	relaxation of cardiac muscle
GO_0086013	Biological process	membrane repolarization during cardiac muscle cell action potential
GO_0031947	Biological process	negative regulation of glucocorticoid biosynthetic process
GO_0045822	Biological process	negative regulation of heart contraction
GO_1903416	Biological process	response to glycoside
GO_0010248	Biological process	establishment or maintenance of transmembrane electrochemical gradient
GO_0007231	Biological process	osmosensory signaling pathway
GO_0045823	Biological process	positive regulation of heart contraction
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0086009	Biological process	membrane repolarization
GO_0030007	Biological process	intracellular potassium ion homeostasis
GO_1902600	Biological process	proton transmembrane transport
GO_1990573	Biological process	potassium ion import across plasma membrane
GO_0016324	Cellular component	apical plasma membrane
GO_0036126	Cellular component	sperm flagellum
GO_0005890	Cellular component	sodium:potassium-exchanging ATPase complex
GO_0005886	Cellular component	plasma membrane
GO_0045121	Cellular component	membrane raft
GO_0016020	Cellular component	membrane
GO_0042383	Cellular component	sarcolemma
GO_0032991	Cellular component	protein-containing complex
GO_1903561	Cellular component	extracellular vesicle
GO_0070062	Cellular component	extracellular exosome
GO_0005794	Cellular component	Golgi apparatus
GO_0030315	Cellular component	T-tubule
GO_0005783	Cellular component	endoplasmic reticulum
GO_0014069	Cellular component	postsynaptic density
GO_0016328	Cellular component	lateral plasma membrane
GO_0060342	Cellular component	photoreceptor inner segment membrane
GO_0030424	Cellular component	axon
GO_0031090	Cellular component	organelle membrane
GO_0042470	Cellular component	melanosome
GO_0016323	Cellular component	basolateral plasma membrane
GO_1990239	Molecular function	steroid hormone binding
GO_0005391	Molecular function	P-type sodium:potassium-exchanging transporter activity
GO_0030955	Molecular function	potassium ion binding
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0005524	Molecular function	ATP binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0031402	Molecular function	sodium ion binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0016791	Molecular function	phosphatase activity
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	ATP1A1
Protein name	Alternative protein ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) ATP1A1 protein Na+/K+ transporting ATPase alpha 1 polypeptide
Synonyms
Description	FUNCTION: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients . Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). .
Accessions	ENST00000537345.5 [P05023-4] ENST00000369496.8 [P05023-3] ENST00000295598.10 [P05023-1] ENST00000369494.5 P05023 L0R4U4 Q5TC05 ENST00000418797.5 ENST00000440951.1 Q5TC01 Q13818 Q58I23 A0A2H4Y9T5 Q5TC02

ATP1A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review