ANP32A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006913Biological processnucleocytoplasmic transport
GO_0035556Biological processintracellular signal transduction
GO_0042981Biological processregulation of apoptotic process
GO_0005654Cellular componentnucleoplasm
GO_0005783Cellular componentendoplasmic reticulum
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0042393Molecular functionhistone binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameANP32A
Protein nameAcidic leucine-rich nuclear phosphoprotein 32 family member
Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI)
SynonymsLANP
PHAP1
MAPM
C15orf1
DescriptionFUNCTION: Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription . Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation . In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking . Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition . Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) . Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A . .; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication . Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region . Also plays an essential role in foamy virus mRNA export from the nucleus . .

FUNCTION: Multifunctional protein that is involved in the regulation of many processes. .

FUNCTION: Multifunctional protein that is involved in the regulation of many processes. .

FUNCTION: Multifunctional protein that is involved in the regulation of many processes. .

FUNCTION: Multifunctional protein that is involved in the regulation of many processes. .

FUNCTION: Multifunctional protein that is involved in the regulation of many processes. .

AccessionsENST00000560303.1
ENST00000409628.6
Q6PKH8
H0YN26
Q08AJ6
Q3KPI8
P39687
ENST00000465139.6
H7BZ09