UBE3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042542Biological processresponse to hydrogen peroxide
GO_0000209Biological processprotein polyubiquitination
GO_2000058Biological processregulation of ubiquitin-dependent protein catabolic process
GO_1990416Biological processcellular response to brain-derived neurotrophic factor stimulus
GO_0001541Biological processovarian follicle development
GO_0051865Biological processprotein autoubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0050847Biological processprogesterone receptor signaling pathway
GO_0035037Biological processsperm entry
GO_0061002Biological processnegative regulation of dendritic spine morphogenesis
GO_0060736Biological processprostate gland growth
GO_1905528Biological processpositive regulation of Golgi lumen acidification
GO_0042752Biological processregulation of circadian rhythm
GO_0042220Biological processresponse to cocaine
GO_0048167Biological processregulation of synaptic plasticity
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0006508Biological processproteolysis
GO_0007420Biological processbrain development
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0030521Biological processandrogen receptor signaling pathway
GO_0035641Biological processlocomotory exploration behavior
GO_0061743Biological processmotor learning
GO_0048511Biological processrhythmic process
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0032570Biological processresponse to progesterone
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000502Cellular componentproteasome complex
GO_0098978Cellular componentglutamatergic synapse
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0046872Molecular functionmetal ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBE3A
Protein nameUbiquitin protein ligase E3A
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Ubiquitin-protein ligase E3A (EC 2.3.2.26)
HECT-type E3 ubiquitin transferase (EC 2.3.2.26)
SynonymshCG_18679
EPVE6AP
E6AP
HPVE6A
DescriptionFUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates . Several substrates have been identified including the BMAL1, ARC, LAMTOR1, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B . Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins . Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component BMAL1, leading to its proteasomal degradation . Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation . Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (By similarity). Required for synaptic remodeling in neurons by mediating ubiquitination and degradation of LAMTOR1, thereby limiting mTORC1 signaling and activity-dependent synaptic remodeling (By similarity). Synergizes with WBP2 in enhancing PGR activity . .; FUNCTION: (Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. .

AccessionsA0A0G2JQQ5
Q96GR7
ENST00000628733.2
ENST00000675177.1
A0A0D9SES7
A0A1B0GTB3
ENST00000604860.3
ENST00000629886.2
ENST00000638155.1 [Q05086-2]
ENST00000636667.1
ENST00000628267.2
A0A6Q8PHE5
Q9H2G0
Q5W7F7
ENST00000629252.2
ENST00000637886.1 [Q05086-3]
A0A0D9SG54
ENST00000625778.3
ENST00000638011.1 [Q05086-2]
ENST00000630907.2
Q9UBN9
ENST00000630424.2 [Q05086-2]
A0A1B0GVL3
A0A0D9SG63
ENST00000625681.2
A0A0D9SG77
A0A0D9SFU3
ENST00000438097.6 [Q05086-2]
S4R306
ENST00000566215.5 [Q05086-2]
ENST00000648336.2 [Q05086-3]
ENST00000626589.2
ENST00000650110.1 [Q05086-1]
ENST00000635914.1
ENST00000649550.1 [Q05086-2]
Q9BUI6
ENST00000626176.2
ENST00000628890.1
A0A0D9SF91
Q05086
A0A0D9SFH3
ENST00000428984.6 [Q05086-2]
A0A0D9SEJ2