TERF2IP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010569Biological processregulation of double-strand break repair via homologous recombination
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0031848Biological processprotection from non-homologous end joining at telomere
GO_0032204Biological processregulation of telomere maintenance
GO_0010833Biological processtelomere maintenance via telomere lengthening
GO_0032205Biological processnegative regulation of telomere maintenance
GO_0048239Biological processnegative regulation of DNA recombination at telomere
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0016233Biological processtelomere capping
GO_0035556Biological processintracellular signal transduction
GO_0070198Biological processprotein localization to chromosome, telomeric region
GO_0032206Biological processpositive regulation of telomere maintenance
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0006355Biological processregulation of DNA-templated transcription
GO_0000723Biological processtelomere maintenance
GO_0007004Biological processtelomere maintenance via telomerase
GO_0000228Cellular componentnuclear chromosome
GO_0000783Cellular componentnuclear telomere cap complex
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005737Cellular componentcytoplasm
GO_0000781Cellular componentchromosome, telomeric region
GO_0070187Cellular componentshelterin complex
GO_0001673Cellular componentmale germ cell nucleus
GO_0005634Cellular componentnucleus
GO_0042162Molecular functiontelomeric DNA binding
GO_0019902Molecular functionphosphatase binding
GO_0098505Molecular functionG-rich strand telomeric DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTERF2IP
Protein nameTelomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1)
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (Repressor/activator protein 1 homolog)
TERF2 interacting protein
SynonymsDRIP5
RAP1
PP8000
DescriptionFUNCTION: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. .

FUNCTION: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression. .

AccessionsH3BMI8
ENST00000300086.5
ENST00000653858.1
Q9NYB0
ENST00000569234.1
ENST00000564671.2
H3BR63
A0A590UJT3