SYK | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	34 studies	34% ± 19%	Explore
B cell	33 studies	36% ± 12%	Explore
classical monocyte	23 studies	35% ± 13%	Explore
memory B cell	19 studies	30% ± 10%	Explore
monocyte	18 studies	37% ± 16%	Explore
conventional dendritic cell	18 studies	34% ± 16%	Explore
plasmacytoid dendritic cell	17 studies	44% ± 13%	Explore
non-classical monocyte	16 studies	29% ± 8%	Explore
microglial cell	15 studies	50% ± 22%	Explore
naive B cell	15 studies	28% ± 7%	Explore
dendritic cell	15 studies	45% ± 15%	Explore
myeloid cell	14 studies	44% ± 16%	Explore
natural killer cell	8 studies	19% ± 3%	Explore
precursor B cell	7 studies	50% ± 17%	Explore
plasma cell	6 studies	33% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	22% ± 9%	Explore
hematopoietic precursor cell	5 studies	41% ± 23%	Explore
pro-B cell	5 studies	39% ± 9%	Explore
immature B cell	5 studies	47% ± 21%	Explore
epithelial cell	5 studies	26% ± 10%	Explore
alveolar macrophage	5 studies	44% ± 19%	Explore
plasmablast	4 studies	33% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	21% ± 6%	Explore
mast cell	4 studies	28% ± 5%	Explore
mononuclear phagocyte	4 studies	38% ± 11%	Explore
intermediate monocyte	4 studies	40% ± 16%	Explore
hematopoietic stem cell	4 studies	23% ± 9%	Explore
leukocyte	3 studies	38% ± 22%	Explore
lymphocyte	3 studies	19% ± 4%	Explore
tissue-resident macrophage	3 studies	32% ± 11%	Explore
germinal center B cell	3 studies	41% ± 11%	Explore
neutrophil	3 studies	28% ± 14%	Explore
transit amplifying cell	3 studies	35% ± 19%	Explore
abnormal cell	3 studies	40% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	7 studies	22% ± 6%	Explore
bone marrow	4 studies	23% ± 7%	Explore
lung	4 studies	20% ± 5%	Explore
brain	3 studies	19% ± 3%	Explore
intestine	3 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	4986.37	653 / 653	100%	77.28	605 / 605
lung	99%	2924.94	572 / 578	99%	43.48	1138 / 1155
pancreas	97%	1263.33	317 / 328	96%	37.53	170 / 178
intestine	92%	2701.81	886 / 966	99%	60.04	521 / 527
stomach	92%	1148.29	331 / 359	98%	51.64	280 / 286
kidney	99%	1917.46	88 / 89	86%	28.22	779 / 901
breast	89%	983.08	408 / 459	91%	26.22	1015 / 1118
esophagus	81%	1780.76	1164 / 1445	96%	42.28	175 / 183
bladder	71%	1415.81	15 / 21	92%	39.48	463 / 504
prostate	87%	970.87	214 / 245	63%	10.09	314 / 502
skin	72%	1514.90	1300 / 1809	63%	19.48	298 / 472
uterus	31%	252.59	53 / 170	89%	41.72	407 / 459
ovary	9%	80.47	17 / 180	99%	46.61	425 / 430
lymph node	0%	0	0 / 0	100%	208.95	29 / 29
peripheral blood	100%	12167.42	929 / 929	0%	0	0 / 0
spleen	100%	9870.85	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	21.23	1 / 1
tonsil	0%	0	0 / 0	98%	77.96	44 / 45
brain	22%	220.16	584 / 2642	76%	18.30	533 / 705
adipose	90%	1293.50	1080 / 1204	0%	0	0 / 0
adrenal gland	65%	578.80	167 / 258	10%	1.52	24 / 230
blood vessel	48%	570.19	636 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	36%	4.98	29 / 80
liver	12%	89.43	26 / 226	20%	4.52	82 / 406
heart	18%	135.16	153 / 861	0%	0	0 / 0
muscle	1%	5.21	7 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051712	Biological process	positive regulation of killing of cells of another organism
GO_0031623	Biological process	receptor internalization
GO_0070372	Biological process	regulation of ERK1 and ERK2 cascade
GO_0002862	Biological process	negative regulation of inflammatory response to antigenic stimulus
GO_0031334	Biological process	positive regulation of protein-containing complex assembly
GO_0030168	Biological process	platelet activation
GO_0043303	Biological process	mast cell degranulation
GO_0001775	Biological process	cell activation
GO_0032725	Biological process	positive regulation of granulocyte macrophage colony-stimulating factor production
GO_0120162	Biological process	positive regulation of cold-induced thermogenesis
GO_0090237	Biological process	regulation of arachidonic acid secretion
GO_0050764	Biological process	regulation of phagocytosis
GO_0071226	Biological process	cellular response to molecule of fungal origin
GO_0002554	Biological process	serotonin secretion by platelet
GO_0006468	Biological process	protein phosphorylation
GO_0030183	Biological process	B cell differentiation
GO_0001525	Biological process	angiogenesis
GO_0002366	Biological process	leukocyte activation involved in immune response
GO_0038156	Biological process	interleukin-3-mediated signaling pathway
GO_0045087	Biological process	innate immune response
GO_0010543	Biological process	regulation of platelet activation
GO_0030593	Biological process	neutrophil chemotaxis
GO_0038063	Biological process	collagen-activated tyrosine kinase receptor signaling pathway
GO_0045588	Biological process	positive regulation of gamma-delta T cell differentiation
GO_0042492	Biological process	gamma-delta T cell differentiation
GO_0043366	Biological process	beta selection
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0006606	Biological process	protein import into nucleus
GO_0032757	Biological process	positive regulation of interleukin-8 production
GO_0002281	Biological process	macrophage activation involved in immune response
GO_0032930	Biological process	positive regulation of superoxide anion generation
GO_0051090	Biological process	regulation of DNA-binding transcription factor activity
GO_0001945	Biological process	lymph vessel development
GO_0046638	Biological process	positive regulation of alpha-beta T cell differentiation
GO_0032760	Biological process	positive regulation of tumor necrosis factor production
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_0033630	Biological process	positive regulation of cell adhesion mediated by integrin
GO_0032753	Biological process	positive regulation of interleukin-4 production
GO_0019722	Biological process	calcium-mediated signaling
GO_0032928	Biological process	regulation of superoxide anion generation
GO_0009887	Biological process	animal organ morphogenesis
GO_0043313	Biological process	regulation of neutrophil degranulation
GO_0019370	Biological process	leukotriene biosynthetic process
GO_0050853	Biological process	B cell receptor signaling pathway
GO_0032481	Biological process	positive regulation of type I interferon production
GO_0010803	Biological process	regulation of tumor necrosis factor-mediated signaling pathway
GO_0045579	Biological process	positive regulation of B cell differentiation
GO_0002223	Biological process	stimulatory C-type lectin receptor signaling pathway
GO_0032765	Biological process	positive regulation of mast cell cytokine production
GO_0071639	Biological process	positive regulation of monocyte chemotactic protein-1 production
GO_1904263	Biological process	positive regulation of TORC1 signaling
GO_1990858	Biological process	cellular response to lectin
GO_0002283	Biological process	neutrophil activation involved in immune response
GO_0043306	Biological process	positive regulation of mast cell degranulation
GO_0007169	Biological process	cell surface receptor protein tyrosine kinase signaling pathway
GO_0050850	Biological process	positive regulation of calcium-mediated signaling
GO_0071396	Biological process	cellular response to lipid
GO_0032735	Biological process	positive regulation of interleukin-12 production
GO_0038095	Biological process	Fc-epsilon receptor signaling pathway
GO_0032733	Biological process	positive regulation of interleukin-10 production
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0043280	Biological process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0002092	Biological process	positive regulation of receptor internalization
GO_0090330	Biological process	regulation of platelet aggregation
GO_0002250	Biological process	adaptive immune response
GO_0032752	Biological process	positive regulation of interleukin-3 production
GO_0018108	Biological process	peptidyl-tyrosine phosphorylation
GO_0071404	Biological process	cellular response to low-density lipoprotein particle stimulus
GO_0035556	Biological process	intracellular signal transduction
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0030154	Biological process	cell differentiation
GO_0046641	Biological process	positive regulation of alpha-beta T cell proliferation
GO_0042742	Biological process	defense response to bacterium
GO_0048514	Biological process	blood vessel morphogenesis
GO_0045780	Biological process	positive regulation of bone resorption
GO_0038096	Biological process	Fc-gamma receptor signaling pathway involved in phagocytosis
GO_0007159	Biological process	leukocyte cell-cell adhesion
GO_0019815	Cellular component	B cell receptor complex
GO_0005634	Cellular component	nucleus
GO_0042101	Cellular component	T cell receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0032991	Cellular component	protein-containing complex
GO_0005737	Cellular component	cytoplasm
GO_0032009	Cellular component	early phagosome
GO_0005829	Cellular component	cytosol
GO_0004672	Molecular function	protein kinase activity
GO_0042169	Molecular function	SH2 domain binding
GO_0097110	Molecular function	scaffold protein binding
GO_0005524	Molecular function	ATP binding
GO_0001784	Molecular function	phosphotyrosine residue binding
GO_0035325	Molecular function	Toll-like receptor binding
GO_0005102	Molecular function	signaling receptor binding
GO_0019902	Molecular function	phosphatase binding
GO_0043274	Molecular function	phospholipase binding
GO_0004715	Molecular function	non-membrane spanning protein tyrosine kinase activity
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0005515	Molecular function	protein binding
GO_0019901	Molecular function	protein kinase binding
GO_0005178	Molecular function	integrin binding
GO_0016301	Molecular function	kinase activity
GO_0016170	Molecular function	interleukin-15 receptor binding

IV. Literature review

[source]

Gene name	SYK
Protein name	Spleen tyrosine kinase Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Synonyms
Description	FUNCTION: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development . Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK . Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition . Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 . Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion . Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). .
Accessions	ENST00000375751.8 [P43405-2] ENST00000375746.1 [P43405-1] ENST00000375754.9 [P43405-1] C3W980 C3W981 P43405 ENST00000375747.5 [P43405-2]

SYK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review