SRPK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0001525Biological processangiogenesis
GO_0045071Biological processnegative regulation of viral genome replication
GO_0045087Biological processinnate immune response
GO_0050684Biological processregulation of mRNA processing
GO_0010628Biological processpositive regulation of gene expression
GO_0035063Biological processnuclear speck organization
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0045070Biological processpositive regulation of viral genome replication
GO_0035556Biological processintracellular signal transduction
GO_0008380Biological processRNA splicing
GO_0048024Biological processregulation of mRNA splicing, via spliceosome
GO_0062176Biological processR-loop processing
GO_0030154Biological processcell differentiation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0006468Biological processprotein phosphorylation
GO_0000245Biological processspliceosomal complex assembly
GO_0045787Biological processpositive regulation of cell cycle
GO_0005730Cellular componentnucleolus
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0071889Molecular function14-3-3 protein binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSRPK2
Protein nameSRSF protein kinase 2
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Uncharacterized protein SRPK2
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Synonyms
DescriptionFUNCTION: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing . Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression . This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression . Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation . Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 . Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA . Can mediate hepatitis B virus (HBV) core protein phosphorylation . Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles . .

AccessionsENST00000474770.1
ENST00000465072.5
C9JWF7
ENST00000482862.2
F8WBW4
ENST00000357311.7 [P78362-1]
ENST00000393651.8 [P78362-2]
ENST00000482897.6
ENST00000460391.6
ENST00000477925.6
C9J2M4
H7C5L6
Q75MW9
ENST00000465112.5
A0A994J591
H7C521
ENST00000489828.5 [P78362-1]
P78362
F8WAV6