SPTBN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	56 studies	66% ± 18%	Explore
fibroblast	48 studies	47% ± 19%	Explore
pericyte	34 studies	48% ± 21%	Explore
endothelial cell of lymphatic vessel	28 studies	67% ± 18%	Explore
smooth muscle cell	25 studies	36% ± 17%	Explore
astrocyte	21 studies	54% ± 20%	Explore
ciliated cell	19 studies	50% ± 17%	Explore
epithelial cell	19 studies	39% ± 17%	Explore
B cell	17 studies	24% ± 7%	Explore
capillary endothelial cell	17 studies	68% ± 16%	Explore
endothelial cell of artery	16 studies	60% ± 15%	Explore
oligodendrocyte	15 studies	52% ± 17%	Explore
oligodendrocyte precursor cell	15 studies	44% ± 16%	Explore
vein endothelial cell	15 studies	64% ± 16%	Explore
endothelial cell of vascular tree	15 studies	49% ± 21%	Explore
natural killer cell	13 studies	19% ± 3%	Explore
basal cell	13 studies	36% ± 16%	Explore
T cell	12 studies	24% ± 9%	Explore
type I pneumocyte	12 studies	68% ± 13%	Explore
type II pneumocyte	12 studies	38% ± 15%	Explore
connective tissue cell	12 studies	45% ± 11%	Explore
glutamatergic neuron	12 studies	67% ± 21%	Explore
myofibroblast cell	12 studies	31% ± 15%	Explore
GABAergic neuron	11 studies	58% ± 21%	Explore
adipocyte	11 studies	64% ± 24%	Explore
neuron	10 studies	57% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	18% ± 4%	Explore
goblet cell	9 studies	33% ± 16%	Explore
memory B cell	9 studies	18% ± 4%	Explore
mesothelial cell	9 studies	39% ± 16%	Explore
mast cell	8 studies	26% ± 9%	Explore
naive B cell	8 studies	20% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	21% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	21% ± 4%	Explore
amacrine cell	8 studies	34% ± 8%	Explore
glial cell	8 studies	42% ± 14%	Explore
club cell	8 studies	37% ± 13%	Explore
CD8-positive, alpha-beta T cell	8 studies	22% ± 6%	Explore
CD4-positive, alpha-beta T cell	7 studies	26% ± 4%	Explore
progenitor cell	7 studies	28% ± 9%	Explore
microglial cell	7 studies	45% ± 25%	Explore
retinal ganglion cell	7 studies	80% ± 15%	Explore
ionocyte	6 studies	45% ± 20%	Explore
hepatocyte	6 studies	52% ± 28%	Explore
abnormal cell	6 studies	39% ± 17%	Explore
interneuron	6 studies	65% ± 18%	Explore
precursor B cell	6 studies	49% ± 6%	Explore
retina horizontal cell	6 studies	52% ± 13%	Explore
retinal cone cell	6 studies	33% ± 11%	Explore
retinal rod cell	6 studies	41% ± 17%	Explore
Mueller cell	6 studies	31% ± 11%	Explore
plasmablast	5 studies	38% ± 15%	Explore
secretory cell	5 studies	40% ± 26%	Explore
macrophage	5 studies	32% ± 21%	Explore
epithelial cell of proximal tubule	5 studies	24% ± 9%	Explore
enterocyte	5 studies	24% ± 6%	Explore
retinal bipolar neuron	5 studies	25% ± 4%	Explore
hematopoietic stem cell	5 studies	25% ± 9%	Explore
pro-B cell	5 studies	41% ± 7%	Explore
brush cell	5 studies	24% ± 13%	Explore
immature B cell	5 studies	28% ± 9%	Explore
adventitial cell	5 studies	48% ± 7%	Explore
cardiac muscle cell	5 studies	66% ± 13%	Explore
melanocyte	5 studies	46% ± 16%	Explore
deuterosomal cell	4 studies	35% ± 12%	Explore
respiratory goblet cell	4 studies	35% ± 11%	Explore
cholangiocyte	4 studies	56% ± 23%	Explore
endothelial cell of sinusoid	4 studies	45% ± 17%	Explore
glomerular endothelial cell	4 studies	78% ± 9%	Explore
renal alpha-intercalated cell	4 studies	31% ± 9%	Explore
transit amplifying cell	4 studies	27% ± 9%	Explore
granule cell	4 studies	54% ± 6%	Explore
kidney loop of Henle epithelial cell	4 studies	33% ± 10%	Explore
Schwann cell	4 studies	66% ± 18%	Explore
lymphocyte	4 studies	42% ± 19%	Explore
OFF-bipolar cell	4 studies	42% ± 27%	Explore
ON-bipolar cell	4 studies	41% ± 29%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	24% ± 3%	Explore
renal principal cell	4 studies	34% ± 12%	Explore
hematopoietic precursor cell	3 studies	39% ± 13%	Explore
pancreatic A cell	3 studies	24% ± 5%	Explore
pancreatic D cell	3 studies	35% ± 17%	Explore
hepatic stellate cell	3 studies	47% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	49% ± 6%	Explore
neural crest cell	3 studies	25% ± 5%	Explore
GABAergic interneuron	3 studies	62% ± 3%	Explore
retinal pigment epithelial cell	3 studies	50% ± 21%	Explore
endocardial cell	3 studies	70% ± 5%	Explore
GABAergic amacrine cell	3 studies	37% ± 5%	Explore
glycinergic amacrine cell	3 studies	32% ± 4%	Explore
rod bipolar cell	3 studies	48% ± 7%	Explore
gamma-delta T cell	3 studies	34% ± 14%	Explore
innate lymphoid cell	3 studies	18% ± 1%	Explore
myoepithelial cell	3 studies	38% ± 13%	Explore
muscle cell	3 studies	36% ± 9%	Explore
pancreatic ductal cell	3 studies	80% ± 12%	Explore
neural progenitor cell	3 studies	23% ± 10%	Explore
ependymal cell	3 studies	59% ± 18%	Explore
enteroendocrine cell	3 studies	45% ± 13%	Explore
chondrocyte	3 studies	39% ± 14%	Explore
regulatory T cell	3 studies	19% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	23% ± 7%	Explore
double negative thymocyte	3 studies	28% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	25% ± 8%	Explore
parietal epithelial cell	3 studies	38% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	41% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	55% ± 20%	Explore
lung	15 studies	35% ± 11%	Explore
eye	11 studies	32% ± 13%	Explore
intestine	9 studies	24% ± 8%	Explore
kidney	7 studies	29% ± 10%	Explore
heart	6 studies	49% ± 17%	Explore
pancreas	4 studies	31% ± 14%	Explore
peripheral blood	4 studies	21% ± 9%	Explore
adipose	4 studies	51% ± 25%	Explore
uterus	3 studies	38% ± 9%	Explore
breast	3 studies	25% ± 6%	Explore
liver	3 studies	41% ± 22%	Explore
bone marrow	3 studies	29% ± 14%	Explore
skin	3 studies	22% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	46428.49	2642 / 2642	100%	139.25	703 / 705
intestine	100%	31540.92	966 / 966	99%	107.09	524 / 527
stomach	99%	21689.10	356 / 359	99%	115.22	284 / 286
lung	100%	65526.40	577 / 578	98%	70.84	1130 / 1155
skin	100%	22892.84	1806 / 1809	98%	132.80	461 / 472
kidney	100%	24372.04	89 / 89	97%	106.09	878 / 901
esophagus	98%	33917.83	1413 / 1445	99%	122.98	182 / 183
breast	100%	49062.20	459 / 459	96%	57.16	1076 / 1118
thymus	100%	37813.40	653 / 653	96%	61.76	579 / 605
prostate	100%	23508.88	244 / 245	95%	57.60	475 / 502
uterus	100%	27867.85	170 / 170	92%	42.82	422 / 459
bladder	100%	25877.29	21 / 21	91%	57.93	458 / 504
adrenal gland	100%	39396.80	258 / 258	90%	55.37	207 / 230
liver	89%	15108.40	201 / 226	99%	74.92	402 / 406
pancreas	79%	9531.89	258 / 328	99%	98.89	177 / 178
ovary	100%	28064.37	180 / 180	73%	25.95	316 / 430
adipose	100%	64468.13	1204 / 1204	0%	0	0 / 0
blood vessel	100%	34352.88	1334 / 1335	0%	0	0 / 0
heart	100%	36770.83	860 / 861	0%	0	0 / 0
spleen	100%	20018.91	240 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	96%	105.35	77 / 80
muscle	91%	11944.53	731 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	84%	38.66	38 / 45
lymph node	0%	0	0 / 0	69%	24.11	20 / 29
peripheral blood	19%	6396.35	176 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0072659	Biological process	protein localization to plasma membrane
GO_0021556	Biological process	central nervous system formation
GO_0000281	Biological process	mitotic cytokinesis
GO_0051693	Biological process	actin filament capping
GO_0060390	Biological process	regulation of SMAD protein signal transduction
GO_0032743	Biological process	positive regulation of interleukin-2 production
GO_0030036	Biological process	actin cytoskeleton organization
GO_1903078	Biological process	positive regulation of protein localization to plasma membrane
GO_0007009	Biological process	plasma membrane organization
GO_0007417	Biological process	central nervous system development
GO_0071709	Biological process	membrane assembly
GO_1903076	Biological process	regulation of protein localization to plasma membrane
GO_0043001	Biological process	Golgi to plasma membrane protein transport
GO_0098978	Cellular component	glutamatergic synapse
GO_0005730	Cellular component	nucleolus
GO_0005886	Cellular component	plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0030864	Cellular component	cortical actin cytoskeleton
GO_0014731	Cellular component	spectrin-associated cytoskeleton
GO_0032437	Cellular component	cuticular plate
GO_0030673	Cellular component	axolemma
GO_0005829	Cellular component	cytosol
GO_0014069	Cellular component	postsynaptic density
GO_0005737	Cellular component	cytoplasm
GO_0042995	Cellular component	cell projection
GO_0030054	Cellular component	cell junction
GO_0031430	Cellular component	M band
GO_0008091	Cellular component	spectrin
GO_0005543	Molecular function	phospholipid binding
GO_0045296	Molecular function	cadherin binding
GO_0051020	Molecular function	GTPase binding
GO_0005200	Molecular function	structural constituent of cytoskeleton
GO_0051015	Molecular function	actin filament binding
GO_0003723	Molecular function	RNA binding
GO_0030506	Molecular function	ankyrin binding
GO_0005516	Molecular function	calmodulin binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding

IV. Literature review

[source]

Gene name	SPTBN1
Protein name	Alternative protein SPTBN1 Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) Spectrin beta chain Spectrin, beta, non-erythrocytic 1, isoform CRA_c (cDNA FLJ55845, highly similar to Spectrin beta chain, brain 1) Spectrin beta, non-erythrocytic 1 Uncharacterized protein SPTBN1
Synonyms	hCG_17370 HEL102 SPTB2
Description	FUNCTION: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. .
Accessions	A0A087WUZ3 ENST00000389980.7 F8W6C1 ENST00000615901.4 ENST00000333896.5 [Q01082-3] B4DIF8 L8ECA0 Q53RC4 ENST00000356805.9 [Q01082-1] K9MS24 B2ZZ89 Q01082

SPTBN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review