SH3BGRL | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	46 studies	52% ± 17%	Explore
B cell	41 studies	42% ± 13%	Explore
endothelial cell	40 studies	37% ± 15%	Explore
fibroblast	40 studies	38% ± 15%	Explore
pericyte	37 studies	49% ± 22%	Explore
natural killer cell	36 studies	35% ± 11%	Explore
smooth muscle cell	31 studies	57% ± 21%	Explore
CD4-positive, alpha-beta T cell	29 studies	31% ± 10%	Explore
T cell	28 studies	29% ± 9%	Explore
conventional dendritic cell	28 studies	62% ± 15%	Explore
CD8-positive, alpha-beta T cell	28 studies	32% ± 11%	Explore
dendritic cell	26 studies	52% ± 21%	Explore
classical monocyte	26 studies	54% ± 15%	Explore
regulatory T cell	25 studies	41% ± 12%	Explore
non-classical monocyte	24 studies	66% ± 16%	Explore
mast cell	23 studies	36% ± 16%	Explore
monocyte	22 studies	50% ± 14%	Explore
endothelial cell of lymphatic vessel	20 studies	35% ± 11%	Explore
memory B cell	20 studies	44% ± 10%	Explore
naive B cell	20 studies	40% ± 11%	Explore
plasmacytoid dendritic cell	19 studies	48% ± 14%	Explore
mature NK T cell	18 studies	34% ± 10%	Explore
connective tissue cell	17 studies	47% ± 17%	Explore
gamma-delta T cell	17 studies	37% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	40% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	29% ± 9%	Explore
myofibroblast cell	15 studies	53% ± 21%	Explore
myeloid cell	15 studies	54% ± 15%	Explore
ciliated cell	15 studies	33% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	34% ± 13%	Explore
capillary endothelial cell	14 studies	32% ± 14%	Explore
epithelial cell	14 studies	33% ± 20%	Explore
microglial cell	14 studies	46% ± 16%	Explore
basal cell	13 studies	34% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	35% ± 9%	Explore
plasma cell	12 studies	30% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	34% ± 14%	Explore
vein endothelial cell	12 studies	34% ± 16%	Explore
astrocyte	12 studies	32% ± 13%	Explore
mucosal invariant T cell	12 studies	32% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	33% ± 11%	Explore
endothelial cell of artery	11 studies	33% ± 12%	Explore
endothelial cell of vascular tree	11 studies	34% ± 14%	Explore
platelet	10 studies	45% ± 15%	Explore
leukocyte	10 studies	39% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	36% ± 14%	Explore
oligodendrocyte precursor cell	10 studies	35% ± 12%	Explore
mesothelial cell	9 studies	36% ± 17%	Explore
glutamatergic neuron	9 studies	37% ± 24%	Explore
alveolar macrophage	8 studies	64% ± 18%	Explore
neutrophil	8 studies	30% ± 11%	Explore
secretory cell	8 studies	25% ± 12%	Explore
GABAergic neuron	8 studies	41% ± 21%	Explore
hematopoietic stem cell	8 studies	62% ± 13%	Explore
plasmablast	7 studies	43% ± 22%	Explore
mononuclear phagocyte	7 studies	55% ± 17%	Explore
progenitor cell	7 studies	41% ± 20%	Explore
abnormal cell	7 studies	39% ± 12%	Explore
neuron	7 studies	32% ± 15%	Explore
precursor B cell	7 studies	49% ± 17%	Explore
innate lymphoid cell	7 studies	35% ± 10%	Explore
erythrocyte	7 studies	34% ± 20%	Explore
T follicular helper cell	7 studies	38% ± 6%	Explore
type I pneumocyte	6 studies	28% ± 7%	Explore
club cell	6 studies	23% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	33% ± 11%	Explore
kidney loop of Henle epithelial cell	6 studies	33% ± 8%	Explore
lymphocyte	6 studies	35% ± 11%	Explore
immature B cell	6 studies	50% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	35% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	33% ± 13%	Explore
hematopoietic precursor cell	5 studies	60% ± 20%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	31% ± 9%	Explore
epithelial cell of proximal tubule	5 studies	23% ± 5%	Explore
pro-B cell	5 studies	48% ± 14%	Explore
type II pneumocyte	5 studies	27% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	42% ± 15%	Explore
intermediate monocyte	5 studies	63% ± 19%	Explore
granulocyte	5 studies	44% ± 18%	Explore
interneuron	5 studies	42% ± 21%	Explore
CD4-positive helper T cell	4 studies	23% ± 6%	Explore
exhausted T cell	4 studies	46% ± 9%	Explore
glomerular endothelial cell	4 studies	39% ± 7%	Explore
renal alpha-intercalated cell	4 studies	44% ± 19%	Explore
glial cell	4 studies	37% ± 19%	Explore
erythroblast	4 studies	59% ± 20%	Explore
brush cell	4 studies	37% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	67% ± 10%	Explore
myoepithelial cell	4 studies	40% ± 5%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	66% ± 31%	Explore
T-helper 17 cell	4 studies	25% ± 7%	Explore
oligodendrocyte	4 studies	30% ± 6%	Explore
double negative thymocyte	4 studies	51% ± 16%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	34% ± 12%	Explore
pancreatic A cell	3 studies	34% ± 12%	Explore
type B pancreatic cell	3 studies	44% ± 7%	Explore
monocyte-derived dendritic cell	3 studies	60% ± 23%	Explore
neural crest cell	3 studies	32% ± 2%	Explore
GABAergic interneuron	3 studies	25% ± 6%	Explore
retinal ganglion cell	3 studies	47% ± 24%	Explore
megakaryocyte	3 studies	54% ± 5%	Explore
enterocyte	3 studies	16% ± 1%	Explore
retinal pigment epithelial cell	3 studies	40% ± 23%	Explore
mucus secreting cell	3 studies	19% ± 1%	Explore
tissue-resident macrophage	3 studies	49% ± 8%	Explore
intraepithelial lymphocyte	3 studies	38% ± 14%	Explore
Mueller cell	3 studies	39% ± 5%	Explore
germinal center B cell	3 studies	47% ± 4%	Explore
inflammatory macrophage	3 studies	40% ± 9%	Explore
muscle cell	3 studies	57% ± 19%	Explore
enteroendocrine cell	3 studies	45% ± 18%	Explore
adventitial cell	3 studies	26% ± 10%	Explore
group 3 innate lymphoid cell	3 studies	43% ± 12%	Explore
melanocyte	3 studies	23% ± 1%	Explore
keratinocyte	3 studies	18% ± 2%	Explore
T-helper 1 cell	3 studies	36% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	37% ± 12%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	31% ± 14%	Explore
renal principal cell	3 studies	36% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	38% ± 15%	Explore
peripheral blood	19 studies	43% ± 13%	Explore
brain	15 studies	32% ± 16%	Explore
intestine	9 studies	35% ± 16%	Explore
kidney	9 studies	35% ± 11%	Explore
bone marrow	5 studies	33% ± 10%	Explore
uterus	5 studies	43% ± 14%	Explore
liver	5 studies	38% ± 24%	Explore
eye	4 studies	26% ± 5%	Explore
adipose	4 studies	28% ± 6%	Explore
lymph node	4 studies	45% ± 10%	Explore
breast	4 studies	38% ± 5%	Explore
pancreas	3 studies	37% ± 8%	Explore
adrenal gland	3 studies	26% ± 10%	Explore
placenta	3 studies	19% ± 2%	Explore
thymus	3 studies	48% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	6946.62	180 / 180	100%	159.13	428 / 430
kidney	100%	5780.34	89 / 89	99%	211.81	894 / 901
thymus	100%	5795.06	651 / 653	100%	217.83	602 / 605
breast	100%	7983.16	459 / 459	99%	604.99	1107 / 1118
adrenal gland	100%	6283.49	258 / 258	99%	225.91	227 / 230
prostate	100%	7858.78	244 / 245	97%	179.43	487 / 502
lung	100%	7265.90	576 / 578	97%	150.83	1119 / 1155
skin	98%	4140.33	1764 / 1809	97%	185.03	460 / 472
esophagus	99%	9249.15	1433 / 1445	95%	123.70	173 / 183
bladder	100%	10820.67	21 / 21	92%	123.11	466 / 504
stomach	98%	6616.07	351 / 359	94%	145.96	268 / 286
intestine	100%	11447.29	964 / 966	90%	117.95	475 / 527
brain	89%	5789.71	2342 / 2642	100%	288.88	705 / 705
pancreas	84%	2186.51	276 / 328	99%	186.28	176 / 178
uterus	100%	11743.35	170 / 170	83%	152.27	380 / 459
adipose	100%	7785.20	1204 / 1204	0%	0	0 / 0
blood vessel	100%	19548.16	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	223.79	80 / 80
lymph node	0%	0	0 / 0	100%	272.49	29 / 29
spleen	100%	7274.04	241 / 241	0%	0	0 / 0
peripheral blood	97%	7792.03	905 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	97.85	43 / 45
heart	67%	2199.82	574 / 861	0%	0	0 / 0
liver	16%	324.30	37 / 226	48%	39.08	196 / 406
muscle	9%	187.04	70 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1904690	Biological process	positive regulation of cytoplasmic translational initiation
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005615	Cellular component	extracellular space
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_1990756	Molecular function	ubiquitin-like ligase-substrate adaptor activity
GO_0140517	Molecular function	protein-RNA adaptor activity
GO_0017124	Molecular function	SH3 domain binding

Gene name	SH3BGRL
Protein name	Adapter SH3BGRL (SH3 domain-binding glutamic acid-rich-like protein 1) SH3 domain-binding glutamic acid-rich-like protein
Synonyms	hCG_14922 HEL-S-115
Description	FUNCTION: Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs . May function as a ubiquitin ligase-substrate adapter . Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs . .
Accessions	O75368 V9HW48 ENST00000373212.6

SH3BGRL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review