SBDS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002244Biological processhematopoietic progenitor cell differentiation
GO_0007052Biological processmitotic spindle organization
GO_0048539Biological processbone marrow development
GO_0001833Biological processinner cell mass cell proliferation
GO_0030595Biological processleukocyte chemotaxis
GO_0030282Biological processbone mineralization
GO_0042256Biological processcytosolic ribosome assembly
GO_0006364Biological processrRNA processing
GO_0005730Cellular componentnucleolus
GO_0000922Cellular componentspindle pole
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019843Molecular functionrRNA binding
GO_0043022Molecular functionribosome binding
GO_0008017Molecular functionmicrotubule binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSBDS
Protein nameRibosome maturation protein SBDS
Ribosome maturation protein SBDS (Shwachman-Bodian-Diamond syndrome protein)
SBDS ribosome maturation factor
Shwachman-Bodian-Diamond syndrome isoform 3
SynonymsCGI-97
DescriptionFUNCTION: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. .

FUNCTION: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. .

FUNCTION: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. .

FUNCTION: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. .

AccessionsENST00000697863.1
ENST00000697865.1
A0A8V8TN15
A0A8V8TLS5
ENST00000697868.1
Q9Y3A5
A0A0S2Z5I7
F8WE72
ENST00000697869.1
ENST00000697897.1
A0A8V8TLR8
A0A0S2Z5F7
ENST00000697862.1
ENST00000697861.1
A0A8V8TMS1
A0A8V8TLA5
A0A8V8TLC6
ENST00000414306.6
A0A8V8TMR6
ENST00000246868.7
ENST00000697866.1
ENST00000697867.1