RAD23A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	33 studies	29% ± 13%	Explore
B cell	31 studies	30% ± 10%	Explore
natural killer cell	31 studies	29% ± 10%	Explore
fibroblast	30 studies	28% ± 11%	Explore
macrophage	27 studies	29% ± 10%	Explore
CD8-positive, alpha-beta T cell	27 studies	33% ± 14%	Explore
CD4-positive, alpha-beta T cell	26 studies	32% ± 15%	Explore
pericyte	25 studies	33% ± 9%	Explore
T cell	24 studies	27% ± 7%	Explore
conventional dendritic cell	24 studies	31% ± 14%	Explore
smooth muscle cell	23 studies	35% ± 10%	Explore
classical monocyte	20 studies	29% ± 10%	Explore
regulatory T cell	20 studies	31% ± 11%	Explore
non-classical monocyte	19 studies	31% ± 12%	Explore
memory B cell	18 studies	31% ± 8%	Explore
monocyte	17 studies	26% ± 10%	Explore
mature NK T cell	17 studies	28% ± 8%	Explore
basal cell	17 studies	33% ± 15%	Explore
naive B cell	17 studies	29% ± 7%	Explore
epithelial cell	17 studies	35% ± 19%	Explore
gamma-delta T cell	16 studies	31% ± 12%	Explore
plasmacytoid dendritic cell	15 studies	33% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	31% ± 8%	Explore
ciliated cell	14 studies	37% ± 15%	Explore
connective tissue cell	13 studies	29% ± 8%	Explore
mast cell	12 studies	22% ± 4%	Explore
endothelial cell of lymphatic vessel	12 studies	37% ± 9%	Explore
plasma cell	12 studies	33% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	29% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	35% ± 8%	Explore
capillary endothelial cell	12 studies	28% ± 9%	Explore
myofibroblast cell	12 studies	32% ± 10%	Explore
vein endothelial cell	12 studies	27% ± 9%	Explore
erythrocyte	11 studies	46% ± 20%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	32% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	32% ± 7%	Explore
endothelial cell of vascular tree	11 studies	32% ± 8%	Explore
myeloid cell	11 studies	33% ± 15%	Explore
plasmablast	10 studies	40% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	33% ± 9%	Explore
secretory cell	10 studies	27% ± 12%	Explore
endothelial cell of artery	10 studies	28% ± 5%	Explore
dendritic cell	10 studies	37% ± 20%	Explore
mucosal invariant T cell	10 studies	32% ± 7%	Explore
type I pneumocyte	8 studies	32% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	31% ± 9%	Explore
abnormal cell	8 studies	38% ± 13%	Explore
goblet cell	7 studies	27% ± 13%	Explore
T follicular helper cell	7 studies	26% ± 6%	Explore
alveolar macrophage	6 studies	24% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	39% ± 14%	Explore
progenitor cell	6 studies	27% ± 7%	Explore
erythroblast	6 studies	44% ± 24%	Explore
innate lymphoid cell	6 studies	27% ± 7%	Explore
type II pneumocyte	6 studies	33% ± 14%	Explore
hematopoietic precursor cell	5 studies	37% ± 12%	Explore
club cell	5 studies	30% ± 9%	Explore
leukocyte	5 studies	28% ± 9%	Explore
mononuclear phagocyte	5 studies	30% ± 14%	Explore
kidney loop of Henle epithelial cell	5 studies	21% ± 6%	Explore
neuron	5 studies	34% ± 15%	Explore
mesothelial cell	5 studies	34% ± 15%	Explore
transit amplifying cell	5 studies	28% ± 7%	Explore
hematopoietic stem cell	5 studies	27% ± 6%	Explore
astrocyte	5 studies	23% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	36% ± 13%	Explore
pancreatic A cell	4 studies	52% ± 18%	Explore
type B pancreatic cell	4 studies	49% ± 17%	Explore
exhausted T cell	4 studies	36% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	31% ± 8%	Explore
epithelial cell of proximal tubule	4 studies	24% ± 8%	Explore
enteroendocrine cell	4 studies	38% ± 15%	Explore
retinal ganglion cell	4 studies	62% ± 29%	Explore
precursor B cell	4 studies	35% ± 8%	Explore
pro-B cell	4 studies	29% ± 5%	Explore
adventitial cell	4 studies	21% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	40% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	28% ± 4%	Explore
oligodendrocyte precursor cell	4 studies	25% ± 6%	Explore
T-helper 17 cell	4 studies	36% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	30% ± 6%	Explore
ionocyte	3 studies	25% ± 7%	Explore
renal alpha-intercalated cell	3 studies	27% ± 7%	Explore
enterocyte	3 studies	19% ± 2%	Explore
intestinal crypt stem cell	3 studies	26% ± 5%	Explore
neural crest cell	3 studies	35% ± 4%	Explore
IgG plasma cell	3 studies	22% ± 3%	Explore
extravillous trophoblast	3 studies	29% ± 7%	Explore
placental villous trophoblast	3 studies	37% ± 12%	Explore
lymphocyte	3 studies	38% ± 4%	Explore
immature B cell	3 studies	35% ± 8%	Explore
amacrine cell	3 studies	45% ± 12%	Explore
retina horizontal cell	3 studies	37% ± 14%	Explore
retinal cone cell	3 studies	43% ± 18%	Explore
microglial cell	3 studies	27% ± 8%	Explore
serous secreting cell	3 studies	21% ± 0%	Explore
intraepithelial lymphocyte	3 studies	29% ± 13%	Explore
Mueller cell	3 studies	23% ± 6%	Explore
germinal center B cell	3 studies	34% ± 4%	Explore
intermediate monocyte	3 studies	47% ± 13%	Explore
adipocyte	3 studies	20% ± 3%	Explore
myoepithelial cell	3 studies	30% ± 7%	Explore
glutamatergic neuron	3 studies	41% ± 18%	Explore
pancreatic ductal cell	3 studies	44% ± 12%	Explore
group 3 innate lymphoid cell	3 studies	38% ± 13%	Explore
keratinocyte	3 studies	20% ± 2%	Explore
T-helper 1 cell	3 studies	39% ± 12%	Explore
double negative thymocyte	3 studies	46% ± 13%	Explore
progenitor cell of mammary luminal epithelium	3 studies	27% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	30% ± 12%	Explore
peripheral blood	16 studies	31% ± 9%	Explore
intestine	8 studies	26% ± 12%	Explore
kidney	7 studies	25% ± 6%	Explore
eye	6 studies	27% ± 12%	Explore
liver	6 studies	31% ± 28%	Explore
lymph node	5 studies	33% ± 9%	Explore
brain	5 studies	30% ± 9%	Explore
pancreas	4 studies	47% ± 20%	Explore
bone marrow	4 studies	24% ± 6%	Explore
uterus	4 studies	33% ± 13%	Explore
breast	4 studies	27% ± 2%	Explore
placenta	3 studies	33% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4682.29	1445 / 1445	100%	130.49	183 / 183
ovary	100%	3678.01	180 / 180	100%	181.06	430 / 430
uterus	100%	4408.64	170 / 170	100%	146.40	459 / 459
skin	100%	4748.86	1808 / 1809	100%	166.48	472 / 472
pancreas	100%	2279.86	327 / 328	100%	108.06	178 / 178
prostate	100%	3639.21	245 / 245	100%	113.01	500 / 502
breast	100%	4822.66	459 / 459	100%	114.10	1113 / 1118
intestine	100%	4638.56	966 / 966	99%	135.60	524 / 527
lung	100%	4448.11	577 / 578	100%	122.87	1150 / 1155
stomach	100%	3429.03	359 / 359	99%	128.01	284 / 286
adrenal gland	100%	4020.43	258 / 258	99%	118.40	228 / 230
kidney	100%	3078.12	89 / 89	99%	100.73	893 / 901
thymus	100%	3772.47	652 / 653	99%	109.59	599 / 605
brain	99%	3275.19	2611 / 2642	100%	124.97	705 / 705
bladder	100%	4913.05	21 / 21	99%	124.87	497 / 504
liver	100%	2165.27	225 / 226	99%	86.48	400 / 406
adipose	100%	5046.09	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5395.13	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	169.43	80 / 80
lymph node	0%	0	0 / 0	100%	129.23	29 / 29
muscle	100%	27817.77	803 / 803	0%	0	0 / 0
spleen	100%	3376.52	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	167.39	45 / 45
ureter	0%	0	0 / 0	100%	70.73	1 / 1
peripheral blood	99%	4089.11	924 / 929	0%	0	0 / 0
heart	97%	4532.96	836 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0032434	Biological process	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006289	Biological process	nucleotide-excision repair
GO_0032436	Biological process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0045787	Biological process	positive regulation of cell cycle
GO_0031648	Biological process	protein destabilization
GO_0045070	Biological process	positive regulation of viral genome replication
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502	Cellular component	proteasome complex
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005794	Cellular component	Golgi apparatus
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005634	Cellular component	nucleus
GO_1990381	Molecular function	ubiquitin-specific protease binding
GO_0070628	Molecular function	proteasome binding
GO_0003697	Molecular function	single-stranded DNA binding
GO_0019900	Molecular function	kinase binding
GO_0031593	Molecular function	polyubiquitin modification-dependent protein binding
GO_0005515	Molecular function	protein binding
GO_0043130	Molecular function	ubiquitin binding
GO_0003684	Molecular function	damaged DNA binding

IV. Literature review

[source]

Gene name	RAD23A
Protein name	UV excision repair protein RAD23 UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) RAD23 homolog A, nucleotide excision repair protein
Synonyms
Description	FUNCTION: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. . FUNCTION: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair. .
Accessions	ENST00000591499.5 ENST00000592268.5 [P54725-2] K7ELW1 A0A494C0B4 ENST00000593114.5 ENST00000586375.1 ENST00000586534.6 [P54725-1] P54725 K7ENJ0 K7EQ16 K7ELU6 ENST00000316856.7 [P54725-3] ENST00000651137.1 ENST00000590881.1

RAD23A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review