RAB1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0006897Biological processendocytosis
GO_0000045Biological processautophagosome assembly
GO_0090110Biological processCOPII-coated vesicle cargo loading
GO_0030252Biological processgrowth hormone secretion
GO_0006886Biological processintracellular protein transport
GO_0032402Biological processmelanosome transport
GO_0016192Biological processvesicle-mediated transport
GO_0007030Biological processGolgi organization
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0019068Biological processvirion assembly
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0042742Biological processdefense response to bacterium
GO_0090557Biological processestablishment of endothelial intestinal barrier
GO_1903020Biological processpositive regulation of glycoprotein metabolic process
GO_0006914Biological processautophagy
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0016477Biological processcell migration
GO_0047496Biological processvesicle transport along microtubule
GO_0012505Cellular componentendomembrane system
GO_0005769Cellular componentearly endosome
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0042470Cellular componentmelanosome
GO_0030658Cellular componenttransport vesicle membrane
GO_0045296Molecular functioncadherin binding
GO_0003925Molecular functionG protein activity
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRAB1A
Protein nameRas-related protein Rab-1A (EC 3.6.5.2) (YPT1-related protein)
Ras-related protein Rab-1A
SynonymshCG_22592
RAB1
DescriptionFUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes . Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion . RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion . Required to modulate the compacted morphology of the Golgi . Regulates the level of CASR present at the cell membrane . Plays a role in cell adhesion and cell migration, via its role in protein trafficking . Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria . Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity). .

AccessionsENST00000409784.8 [P62820-1]
ENST00000409892.5 [P62820-2]
ENST00000409751.1
Q5U0I6
E7END7
ENST00000649427.1 [P62820-1]
ENST00000398529.7 [P62820-3]
P62820