PSMD4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	28 studies	27% ± 8%	Explore
B cell	26 studies	25% ± 8%	Explore
fibroblast	26 studies	26% ± 10%	Explore
endothelial cell	24 studies	28% ± 12%	Explore
smooth muscle cell	21 studies	28% ± 8%	Explore
conventional dendritic cell	21 studies	29% ± 15%	Explore
non-classical monocyte	20 studies	31% ± 13%	Explore
CD8-positive, alpha-beta T cell	20 studies	28% ± 10%	Explore
pericyte	20 studies	27% ± 8%	Explore
T cell	19 studies	24% ± 8%	Explore
CD4-positive, alpha-beta T cell	19 studies	26% ± 11%	Explore
regulatory T cell	19 studies	27% ± 9%	Explore
classical monocyte	18 studies	27% ± 11%	Explore
macrophage	18 studies	26% ± 10%	Explore
ciliated cell	16 studies	36% ± 14%	Explore
basal cell	15 studies	28% ± 14%	Explore
monocyte	14 studies	27% ± 8%	Explore
dendritic cell	14 studies	29% ± 17%	Explore
mast cell	13 studies	19% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	27% ± 7%	Explore
naive B cell	13 studies	22% ± 6%	Explore
mature NK T cell	13 studies	23% ± 6%	Explore
epithelial cell	13 studies	35% ± 19%	Explore
gamma-delta T cell	13 studies	27% ± 15%	Explore
memory B cell	12 studies	24% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	25% ± 6%	Explore
capillary endothelial cell	11 studies	22% ± 5%	Explore
connective tissue cell	11 studies	28% ± 10%	Explore
plasma cell	10 studies	30% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	23% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	28% ± 7%	Explore
myeloid cell	10 studies	24% ± 12%	Explore
myofibroblast cell	9 studies	30% ± 7%	Explore
abnormal cell	9 studies	34% ± 13%	Explore
mucosal invariant T cell	9 studies	23% ± 5%	Explore
endothelial cell of vascular tree	9 studies	25% ± 5%	Explore
endothelial cell of lymphatic vessel	9 studies	27% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	26% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	28% ± 10%	Explore
vein endothelial cell	8 studies	24% ± 6%	Explore
plasmacytoid dendritic cell	8 studies	27% ± 8%	Explore
plasmablast	7 studies	42% ± 23%	Explore
neuron	7 studies	36% ± 15%	Explore
endothelial cell of artery	7 studies	24% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	35% ± 15%	Explore
erythrocyte	6 studies	27% ± 18%	Explore
T follicular helper cell	6 studies	19% ± 3%	Explore
hematopoietic precursor cell	5 studies	39% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	30% ± 5%	Explore
epithelial cell of proximal tubule	5 studies	22% ± 7%	Explore
progenitor cell	5 studies	23% ± 7%	Explore
erythroblast	5 studies	35% ± 21%	Explore
innate lymphoid cell	5 studies	23% ± 5%	Explore
oligodendrocyte precursor cell	5 studies	28% ± 8%	Explore
goblet cell	5 studies	28% ± 9%	Explore
secretory cell	4 studies	31% ± 14%	Explore
leukocyte	4 studies	30% ± 7%	Explore
exhausted T cell	4 studies	35% ± 9%	Explore
intestinal crypt stem cell	4 studies	21% ± 5%	Explore
mesothelial cell	4 studies	31% ± 16%	Explore
retinal ganglion cell	4 studies	60% ± 28%	Explore
immature B cell	4 studies	35% ± 16%	Explore
precursor B cell	4 studies	32% ± 12%	Explore
pro-B cell	4 studies	31% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	37% ± 7%	Explore
glutamatergic neuron	4 studies	41% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	32% ± 7%	Explore
enteroendocrine cell	4 studies	33% ± 14%	Explore
oligodendrocyte	4 studies	21% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	22% ± 8%	Explore
pancreatic A cell	3 studies	37% ± 7%	Explore
type B pancreatic cell	3 studies	41% ± 2%	Explore
mononuclear phagocyte	3 studies	37% ± 15%	Explore
glomerular endothelial cell	3 studies	20% ± 3%	Explore
kidney loop of Henle epithelial cell	3 studies	22% ± 1%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	36% ± 14%	Explore
neural crest cell	3 studies	34% ± 4%	Explore
placental villous trophoblast	3 studies	51% ± 20%	Explore
lymphocyte	3 studies	28% ± 8%	Explore
brush cell	3 studies	29% ± 6%	Explore
club cell	3 studies	31% ± 8%	Explore
type II pneumocyte	3 studies	28% ± 13%	Explore
astrocyte	3 studies	26% ± 9%	Explore
retina horizontal cell	3 studies	33% ± 15%	Explore
microglial cell	3 studies	24% ± 5%	Explore
intraepithelial lymphocyte	3 studies	30% ± 10%	Explore
germinal center B cell	3 studies	26% ± 0%	Explore
intermediate monocyte	3 studies	38% ± 19%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	19% ± 2%	Explore
GABAergic neuron	3 studies	37% ± 14%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	39% ± 25%	Explore
enterocyte	3 studies	17% ± 2%	Explore
T-helper 1 cell	3 studies	30% ± 9%	Explore
double negative thymocyte	3 studies	41% ± 18%	Explore
hematopoietic stem cell	3 studies	28% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	30% ± 7%	Explore
lung	12 studies	30% ± 11%	Explore
intestine	7 studies	25% ± 11%	Explore
brain	7 studies	28% ± 11%	Explore
kidney	6 studies	25% ± 5%	Explore
liver	6 studies	30% ± 21%	Explore
eye	5 studies	25% ± 11%	Explore
bone marrow	5 studies	19% ± 3%	Explore
lymph node	5 studies	24% ± 7%	Explore
uterus	4 studies	29% ± 14%	Explore
pancreas	3 studies	39% ± 5%	Explore
placenta	3 studies	33% ± 19%	Explore
breast	3 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6731.11	1445 / 1445	100%	126.72	183 / 183
liver	100%	4511.16	226 / 226	100%	246.56	406 / 406
ovary	100%	4938.98	180 / 180	100%	117.88	430 / 430
uterus	100%	5779.61	170 / 170	100%	234.28	459 / 459
skin	100%	6234.47	1808 / 1809	100%	203.86	472 / 472
brain	100%	6599.06	2639 / 2642	100%	175.91	705 / 705
thymus	100%	4836.97	652 / 653	100%	161.03	605 / 605
breast	100%	5959.17	459 / 459	100%	219.11	1114 / 1118
lung	100%	5142.39	577 / 578	100%	178.60	1152 / 1155
intestine	100%	6628.52	966 / 966	99%	147.60	524 / 527
prostate	100%	5323.56	245 / 245	99%	146.53	499 / 502
stomach	100%	5084.02	359 / 359	99%	128.97	284 / 286
pancreas	100%	3279.76	327 / 328	99%	153.15	177 / 178
adrenal gland	100%	6245.77	258 / 258	99%	127.92	228 / 230
bladder	100%	6992.10	21 / 21	99%	199.31	498 / 504
kidney	100%	5080.46	89 / 89	99%	106.97	889 / 901
adipose	100%	6177.94	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	154.78	80 / 80
lymph node	0%	0	0 / 0	100%	299.29	29 / 29
muscle	100%	13847.36	803 / 803	0%	0	0 / 0
spleen	100%	6306.70	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	183.50	45 / 45
ureter	0%	0	0 / 0	100%	149.97	1 / 1
blood vessel	100%	7006.20	1334 / 1335	0%	0	0 / 0
peripheral blood	99%	6798.58	924 / 929	0%	0	0 / 0
heart	99%	5671.00	849 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502	Cellular component	proteasome complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0008540	Cellular component	proteasome regulatory particle, base subcomplex
GO_0022624	Cellular component	proteasome accessory complex
GO_0005634	Cellular component	nucleus
GO_0031593	Molecular function	polyubiquitin modification-dependent protein binding
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0060090	Molecular function	molecular adaptor activity
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	PSMD4
Protein name	26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein) Proteasome 26S subunit ubiquitin receptor, non-ATPase 4 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10)
Synonyms	hCG_1741224 MCB1
Description	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. .
Accessions	H0Y3Y9 Q5VWC4 ENST00000445776.1 P55036 ENST00000437736.5 H0Y561 A6PVX3 ENST00000427779.5 ENST00000368884.8 [P55036-1] ENST00000368881.8 ENST00000453615.1 H7C2J9

PSMD4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review