PPHLN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	28 studies	23% ± 8%	Explore
natural killer cell	24 studies	22% ± 6%	Explore
regulatory T cell	21 studies	21% ± 4%	Explore
CD4-positive, alpha-beta T cell	19 studies	22% ± 8%	Explore
CD8-positive, alpha-beta T cell	19 studies	22% ± 7%	Explore
endothelial cell	18 studies	29% ± 11%	Explore
T cell	15 studies	21% ± 4%	Explore
memory B cell	15 studies	20% ± 3%	Explore
fibroblast	14 studies	24% ± 8%	Explore
naive B cell	13 studies	20% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	23% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	23% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	22% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	21% ± 6%	Explore
mature NK T cell	11 studies	20% ± 3%	Explore
plasmacytoid dendritic cell	11 studies	25% ± 8%	Explore
gamma-delta T cell	11 studies	25% ± 11%	Explore
glutamatergic neuron	10 studies	50% ± 27%	Explore
microglial cell	10 studies	30% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	23% ± 7%	Explore
astrocyte	10 studies	34% ± 18%	Explore
oligodendrocyte	10 studies	28% ± 13%	Explore
oligodendrocyte precursor cell	9 studies	30% ± 13%	Explore
mucosal invariant T cell	9 studies	20% ± 2%	Explore
dendritic cell	9 studies	28% ± 19%	Explore
GABAergic neuron	8 studies	44% ± 25%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	26% ± 9%	Explore
macrophage	8 studies	30% ± 9%	Explore
pericyte	8 studies	21% ± 7%	Explore
smooth muscle cell	8 studies	19% ± 2%	Explore
epithelial cell	8 studies	39% ± 22%	Explore
basal cell	8 studies	30% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	21% ± 4%	Explore
ciliated cell	7 studies	27% ± 9%	Explore
type I pneumocyte	7 studies	21% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	19% ± 2%	Explore
conventional dendritic cell	6 studies	34% ± 15%	Explore
abnormal cell	6 studies	25% ± 12%	Explore
interneuron	6 studies	45% ± 27%	Explore
myeloid cell	6 studies	23% ± 9%	Explore
adipocyte	6 studies	23% ± 4%	Explore
T follicular helper cell	6 studies	21% ± 5%	Explore
endothelial cell of lymphatic vessel	6 studies	26% ± 6%	Explore
type II pneumocyte	6 studies	20% ± 4%	Explore
leukocyte	5 studies	24% ± 4%	Explore
neuron	5 studies	34% ± 10%	Explore
precursor B cell	5 studies	29% ± 7%	Explore
monocyte	5 studies	24% ± 4%	Explore
hematopoietic stem cell	5 studies	18% ± 1%	Explore
mast cell	5 studies	21% ± 4%	Explore
club cell	5 studies	22% ± 6%	Explore
exhausted T cell	4 studies	27% ± 14%	Explore
hematopoietic precursor cell	4 studies	41% ± 16%	Explore
connective tissue cell	4 studies	20% ± 4%	Explore
granule cell	4 studies	24% ± 7%	Explore
myofibroblast cell	4 studies	22% ± 6%	Explore
plasma cell	4 studies	30% ± 13%	Explore
immature B cell	4 studies	24% ± 5%	Explore
pro-B cell	4 studies	26% ± 5%	Explore
lymphocyte	4 studies	33% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	27% ± 15%	Explore
innate lymphoid cell	4 studies	21% ± 3%	Explore
goblet cell	4 studies	33% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	20% ± 3%	Explore
pancreatic A cell	3 studies	27% ± 8%	Explore
classical monocyte	3 studies	27% ± 8%	Explore
non-classical monocyte	3 studies	27% ± 9%	Explore
plasmablast	3 studies	43% ± 17%	Explore
podocyte	3 studies	23% ± 2%	Explore
GABAergic interneuron	3 studies	25% ± 2%	Explore
progenitor cell	3 studies	22% ± 3%	Explore
retinal ganglion cell	3 studies	30% ± 5%	Explore
amacrine cell	3 studies	22% ± 5%	Explore
retinal bipolar neuron	3 studies	22% ± 5%	Explore
retinal rod cell	3 studies	19% ± 4%	Explore
cardiac muscle cell	3 studies	18% ± 2%	Explore
OFF-bipolar cell	3 studies	17% ± 2%	Explore
glycinergic amacrine cell	3 studies	17% ± 1%	Explore
rod bipolar cell	3 studies	19% ± 2%	Explore
erythroblast	3 studies	32% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	21% ± 2%	Explore
ependymal cell	3 studies	29% ± 15%	Explore
enteroendocrine cell	3 studies	21% ± 8%	Explore
intestinal crypt stem cell	3 studies	19% ± 3%	Explore
alveolar macrophage	3 studies	27% ± 6%	Explore
transit amplifying cell	3 studies	40% ± 29%	Explore
T-helper 17 cell	3 studies	20% ± 3%	Explore
double negative thymocyte	3 studies	34% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	37% ± 21%	Explore
peripheral blood	12 studies	24% ± 9%	Explore
lung	9 studies	23% ± 4%	Explore
eye	5 studies	26% ± 13%	Explore
bone marrow	4 studies	18% ± 2%	Explore
lymph node	4 studies	19% ± 4%	Explore
heart	3 studies	16% ± 0%	Explore
intestine	3 studies	23% ± 8%	Explore
adipose	3 studies	24% ± 2%	Explore
liver	3 studies	39% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	2778.84	459 / 459	100%	14.49	1118 / 1118
esophagus	100%	2496.87	1445 / 1445	100%	12.29	183 / 183
lung	100%	2540.32	578 / 578	100%	13.38	1155 / 1155
ovary	100%	3324.46	180 / 180	100%	11.82	430 / 430
uterus	100%	3004.72	170 / 170	100%	13.68	459 / 459
thymus	100%	2662.74	653 / 653	100%	12.49	604 / 605
intestine	100%	2837.36	966 / 966	100%	12.29	526 / 527
bladder	100%	2602.43	21 / 21	100%	12.69	503 / 504
prostate	100%	2634.98	245 / 245	100%	9.96	501 / 502
liver	100%	1372.12	226 / 226	100%	6.72	405 / 406
kidney	100%	2175.25	89 / 89	100%	10.43	898 / 901
stomach	100%	2096.26	359 / 359	100%	11.70	285 / 286
brain	100%	2225.31	2631 / 2642	100%	11.56	705 / 705
skin	100%	2992.22	1809 / 1809	100%	14.22	470 / 472
adrenal gland	100%	2920.52	258 / 258	99%	12.62	228 / 230
pancreas	100%	1545.85	327 / 328	99%	11.13	176 / 178
adipose	100%	2603.81	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	20.10	29 / 29
spleen	100%	3468.91	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	12.81	45 / 45
ureter	0%	0	0 / 0	100%	7.93	1 / 1
blood vessel	100%	2669.53	1334 / 1335	0%	0	0 / 0
muscle	100%	1854.17	801 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	98%	9.65	78 / 80
heart	97%	1759.81	838 / 861	0%	0	0 / 0
peripheral blood	92%	2055.58	859 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0097355	Biological process	protein localization to heterochromatin
GO_0045814	Biological process	negative regulation of gene expression, epigenetic
GO_0090309	Biological process	positive regulation of DNA methylation-dependent heterochromatin formation
GO_0031424	Biological process	keratinization
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0005694	Cellular component	chromosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005794	Cellular component	Golgi apparatus
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	PPHLN1
Protein name	Periphilin 1 Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) Periphilin 1 (cDNA FLJ52823, highly similar to Periphilin-1)
Synonyms	HSPC232 HSPC206
Description	FUNCTION: Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin . Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex . The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed . May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation . .
Accessions	F8W0Q9 F8VP48 ENST00000547847.1 ENST00000619544.4 [Q8NEY8-3] ENST00000395568.6 [Q8NEY8-1] ENST00000552761.5 [Q8NEY8-6] ENST00000610488.4 [Q8NEY8-1] F8VPY7 ENST00000449194.6 [Q8NEY8-9] Q8NEY8 ENST00000546750.5 ENST00000551723.5 F8W6A0 F8VRK2 ENST00000337898.10 B7Z8L1 ENST00000432191.6 [Q8NEY8-3] ENST00000613154.4 [Q8NEY8-9] ENST00000549190.5 ENST00000317560.13 ENST00000395580.7 [Q8NEY8-2] ENST00000358314.12 [Q8NEY8-8] F8VXV7 ENST00000256678.12 F8VWU8 ENST00000551658.1 ENST00000552429.5 F8WF16

PPHLN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review