OSTC | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	34 studies	47% ± 21%	Explore
natural killer cell	32 studies	29% ± 9%	Explore
endothelial cell	31 studies	36% ± 16%	Explore
macrophage	28 studies	29% ± 12%	Explore
conventional dendritic cell	27 studies	41% ± 14%	Explore
CD8-positive, alpha-beta T cell	27 studies	30% ± 13%	Explore
T cell	26 studies	27% ± 13%	Explore
CD4-positive, alpha-beta T cell	26 studies	30% ± 11%	Explore
plasma cell	24 studies	49% ± 23%	Explore
plasmacytoid dendritic cell	23 studies	60% ± 16%	Explore
B cell	22 studies	24% ± 10%	Explore
pericyte	22 studies	40% ± 23%	Explore
classical monocyte	20 studies	28% ± 11%	Explore
smooth muscle cell	19 studies	38% ± 18%	Explore
mature NK T cell	18 studies	27% ± 9%	Explore
regulatory T cell	18 studies	26% ± 8%	Explore
epithelial cell	17 studies	48% ± 25%	Explore
connective tissue cell	17 studies	57% ± 24%	Explore
mast cell	15 studies	31% ± 15%	Explore
monocyte	15 studies	31% ± 10%	Explore
endothelial cell of lymphatic vessel	15 studies	35% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	26% ± 8%	Explore
non-classical monocyte	15 studies	27% ± 10%	Explore
gamma-delta T cell	15 studies	29% ± 14%	Explore
dendritic cell	13 studies	43% ± 24%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	24% ± 5%	Explore
myofibroblast cell	13 studies	48% ± 21%	Explore
plasmablast	12 studies	61% ± 22%	Explore
basal cell	12 studies	41% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	30% ± 8%	Explore
mucosal invariant T cell	12 studies	29% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	30% ± 8%	Explore
endothelial cell of artery	11 studies	30% ± 15%	Explore
vein endothelial cell	11 studies	32% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	28% ± 13%	Explore
secretory cell	10 studies	39% ± 19%	Explore
goblet cell	10 studies	38% ± 16%	Explore
mesothelial cell	10 studies	65% ± 25%	Explore
endothelial cell of vascular tree	10 studies	26% ± 6%	Explore
myeloid cell	10 studies	33% ± 13%	Explore
naive B cell	9 studies	21% ± 5%	Explore
progenitor cell	9 studies	57% ± 20%	Explore
abnormal cell	9 studies	32% ± 11%	Explore
memory B cell	9 studies	20% ± 5%	Explore
ciliated cell	9 studies	41% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	31% ± 12%	Explore
leukocyte	8 studies	29% ± 11%	Explore
innate lymphoid cell	8 studies	39% ± 12%	Explore
capillary endothelial cell	8 studies	29% ± 14%	Explore
IgG plasma cell	8 studies	34% ± 14%	Explore
club cell	7 studies	37% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	26% ± 7%	Explore
epithelial cell of proximal tubule	7 studies	31% ± 18%	Explore
IgA plasma cell	7 studies	38% ± 16%	Explore
hematopoietic stem cell	7 studies	43% ± 15%	Explore
T follicular helper cell	7 studies	24% ± 3%	Explore
hematopoietic precursor cell	6 studies	52% ± 24%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	39% ± 14%	Explore
enterocyte	6 studies	32% ± 15%	Explore
neuron	6 studies	37% ± 17%	Explore
respiratory goblet cell	5 studies	30% ± 22%	Explore
mononuclear phagocyte	5 studies	42% ± 18%	Explore
kidney loop of Henle epithelial cell	5 studies	22% ± 5%	Explore
intestinal crypt stem cell	5 studies	34% ± 11%	Explore
transit amplifying cell	5 studies	25% ± 5%	Explore
precursor B cell	5 studies	38% ± 13%	Explore
pro-B cell	5 studies	37% ± 8%	Explore
immature B cell	5 studies	37% ± 20%	Explore
type II pneumocyte	5 studies	45% ± 22%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	33% ± 13%	Explore
alveolar macrophage	4 studies	24% ± 5%	Explore
pancreatic A cell	4 studies	45% ± 13%	Explore
type B pancreatic cell	4 studies	62% ± 18%	Explore
exhausted T cell	4 studies	39% ± 11%	Explore
enteroendocrine cell	4 studies	53% ± 16%	Explore
erythroblast	4 studies	43% ± 16%	Explore
type I pneumocyte	4 studies	37% ± 15%	Explore
adventitial cell	4 studies	40% ± 8%	Explore
acinar cell	4 studies	45% ± 20%	Explore
muscle cell	4 studies	29% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	45% ± 12%	Explore
CD4-positive helper T cell	4 studies	20% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	37% ± 3%	Explore
T-helper 17 cell	4 studies	38% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	25% ± 6%	Explore
duct epithelial cell	3 studies	27% ± 0%	Explore
precursor cell	3 studies	53% ± 15%	Explore
pancreatic D cell	3 studies	62% ± 15%	Explore
glomerular endothelial cell	3 studies	18% ± 1%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	59% ± 24%	Explore
neural crest cell	3 studies	64% ± 5%	Explore
extravillous trophoblast	3 studies	81% ± 7%	Explore
placental villous trophoblast	3 studies	65% ± 4%	Explore
common myeloid progenitor	3 studies	49% ± 23%	Explore
lymphocyte	3 studies	39% ± 14%	Explore
serous secreting cell	3 studies	38% ± 14%	Explore
intraepithelial lymphocyte	3 studies	32% ± 15%	Explore
germinal center B cell	3 studies	28% ± 7%	Explore
intermediate monocyte	3 studies	39% ± 15%	Explore
IgM plasma cell	3 studies	45% ± 12%	Explore
glutamatergic neuron	3 studies	22% ± 5%	Explore
pancreatic ductal cell	3 studies	56% ± 9%	Explore
granulocyte	3 studies	36% ± 10%	Explore
granulocyte monocyte progenitor cell	3 studies	63% ± 17%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	56% ± 27%	Explore
glial cell	3 studies	45% ± 27%	Explore
erythrocyte	3 studies	42% ± 14%	Explore
group 3 innate lymphoid cell	3 studies	51% ± 16%	Explore
keratinocyte	3 studies	20% ± 3%	Explore
T-helper 1 cell	3 studies	35% ± 9%	Explore
double negative thymocyte	3 studies	46% ± 26%	Explore
progenitor cell of mammary luminal epithelium	3 studies	32% ± 2%	Explore
hepatocyte	3 studies	48% ± 35%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	34% ± 19%	Explore
peripheral blood	14 studies	30% ± 8%	Explore
intestine	11 studies	37% ± 20%	Explore
kidney	8 studies	33% ± 13%	Explore
bone marrow	6 studies	25% ± 11%	Explore
pancreas	5 studies	46% ± 21%	Explore
lymph node	5 studies	25% ± 8%	Explore
liver	5 studies	35% ± 19%	Explore
placenta	4 studies	54% ± 20%	Explore
eye	4 studies	20% ± 4%	Explore
uterus	4 studies	48% ± 20%	Explore
breast	4 studies	30% ± 4%	Explore
brain	4 studies	21% ± 2%	Explore
adrenal gland	3 studies	24% ± 3%	Explore
skin	3 studies	28% ± 3%	Explore
thymus	3 studies	53% ± 27%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2317.21	1445 / 1445	100%	114.72	183 / 183
liver	100%	4085.50	226 / 226	100%	146.82	406 / 406
lung	100%	3122.16	578 / 578	100%	194.15	1155 / 1155
ovary	100%	2993.54	180 / 180	100%	151.96	430 / 430
pancreas	100%	3341.82	328 / 328	100%	172.18	178 / 178
skin	100%	4215.93	1808 / 1809	100%	197.93	472 / 472
breast	100%	2784.38	459 / 459	100%	207.97	1117 / 1118
bladder	100%	2598.19	21 / 21	100%	173.74	503 / 504
uterus	100%	2880.49	170 / 170	100%	198.34	458 / 459
stomach	100%	2375.23	359 / 359	100%	143.23	285 / 286
intestine	100%	2551.41	966 / 966	100%	166.96	525 / 527
prostate	100%	2407.31	245 / 245	100%	168.63	500 / 502
thymus	100%	2716.27	653 / 653	99%	140.20	601 / 605
kidney	100%	2457.85	89 / 89	99%	131.02	892 / 901
adrenal gland	100%	3249.73	258 / 258	98%	107.81	225 / 230
brain	92%	836.44	2438 / 2642	97%	82.30	685 / 705
adipose	100%	2897.53	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	104.54	80 / 80
lymph node	0%	0	0 / 0	100%	142.57	29 / 29
spleen	100%	3188.04	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	145.27	45 / 45
ureter	0%	0	0 / 0	100%	129.31	1 / 1
blood vessel	100%	2790.53	1332 / 1335	0%	0	0 / 0
heart	97%	1468.30	835 / 861	0%	0	0 / 0
muscle	79%	587.86	635 / 803	0%	0	0 / 0
peripheral blood	79%	1793.30	731 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	OSTC
Protein name	Oligosaccharyltransferase complex subunit OSTC (Hydrophobic protein HSF-28) Oligosaccharyltransferase complex subunit
Synonyms	DC2 HSPC307 HDCMD45P
Description	FUNCTION: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation . N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. . FUNCTION: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. .
Accessions	Q9NRP0 ENST00000613215.4 ENST00000512478.2 [Q9NRP0-2] ENST00000361564.9 [Q9NRP0-1] A0A087WUD3

GO_0018279	Biological process	protein N-linked glycosylation via asparagine
GO_0006487	Biological process	protein N-linked glycosylation
GO_0008250	Cellular component	oligosaccharyltransferase complex
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0004579	Molecular function	dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO_0005515	Molecular function	protein binding

OSTC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review