NOP58 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006364Biological processrRNA processing
GO_0048254Biological processsnoRNA localization
GO_0042274Biological processribosomal small subunit biogenesis
GO_0015030Cellular componentCajal body
GO_0005732Cellular componentsno(s)RNA-containing ribonucleoprotein complex
GO_0005730Cellular componentnucleolus
GO_0070761Cellular componentpre-snoRNP complex
GO_0001650Cellular componentfibrillar center
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031428Cellular componentbox C/D methylation guide snoRNP complex
GO_0016020Cellular componentmembrane
GO_0032040Cellular componentsmall-subunit processome
GO_0001094Molecular functionTFIID-class transcription factor complex binding
GO_0051117Molecular functionATPase binding
GO_0030515Molecular functionsnoRNA binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNOP58
Protein nameNOP58 ribonucleoprotein
Nucleolar protein 58 (Nucleolar protein 5)
SynonymsHSPC120
NOP5
NOL5
DescriptionFUNCTION: Required for 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . .

AccessionsENST00000433543.2
F8WED0
ENST00000426814.5
Q9Y2X3
ENST00000264279.10
H7BZ72