NOL7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030490Biological processmaturation of SSU-rRNA
GO_0042274Biological processribosomal small subunit biogenesis
GO_0005730Cellular componentnucleolus
GO_0005694Cellular componentchromosome
GO_0005739Cellular componentmitochondrion
GO_0032040Cellular componentsmall-subunit processome
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNOL7
Protein nameNucleolar protein 7
U3 small nucleolar RNA-associated protein NOL7 (U3 snoRNA-associated protein NOL7) (Nucleolar protein 7) (Nucleolar protein of 27 kDa)
SynonymsC6orf90
NOP27
DescriptionFUNCTION: Functions as part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit that coordinates the first two steps of ribosome biogenesis in transcription of the primary transcript pre-RNA and pre-18S processing . During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . This subunit is required for processing of the 5'-external transcribed spacer sequence (5'ETS) of the primary transcript pre-rRNA to yield the 18S rRNA . Also plays a role in maintaining early pre-rRNA levels, either by assisting in its transcription or stability . .

AccessionsQ9UMY1
ENST00000420088.1
H7C2B1
ENST00000451315.7 [Q9UMY1-1]