MPC2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	26 studies	24% ± 9%	Explore
CD4-positive, alpha-beta T cell	24 studies	24% ± 8%	Explore
fibroblast	24 studies	26% ± 14%	Explore
T cell	21 studies	24% ± 9%	Explore
CD8-positive, alpha-beta T cell	20 studies	25% ± 8%	Explore
regulatory T cell	20 studies	26% ± 5%	Explore
conventional dendritic cell	19 studies	25% ± 13%	Explore
B cell	18 studies	26% ± 11%	Explore
ciliated cell	16 studies	53% ± 14%	Explore
epithelial cell	15 studies	46% ± 26%	Explore
macrophage	15 studies	22% ± 7%	Explore
endothelial cell	15 studies	26% ± 10%	Explore
pericyte	15 studies	19% ± 4%	Explore
gamma-delta T cell	14 studies	27% ± 13%	Explore
smooth muscle cell	14 studies	24% ± 6%	Explore
basal cell	12 studies	31% ± 13%	Explore
mature NK T cell	12 studies	22% ± 5%	Explore
plasma cell	11 studies	26% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	23% ± 6%	Explore
connective tissue cell	10 studies	24% ± 8%	Explore
goblet cell	10 studies	39% ± 18%	Explore
naive B cell	9 studies	19% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	21% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	24% ± 6%	Explore
dendritic cell	9 studies	39% ± 25%	Explore
memory B cell	9 studies	18% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	26% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	27% ± 4%	Explore
enterocyte	8 studies	41% ± 20%	Explore
mucosal invariant T cell	8 studies	21% ± 3%	Explore
mast cell	7 studies	20% ± 4%	Explore
plasmablast	7 studies	40% ± 24%	Explore
secretory cell	7 studies	28% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	27% ± 9%	Explore
epithelial cell of proximal tubule	7 studies	59% ± 16%	Explore
progenitor cell	7 studies	55% ± 26%	Explore
abnormal cell	7 studies	45% ± 16%	Explore
myeloid cell	7 studies	28% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	25% ± 6%	Explore
club cell	6 studies	28% ± 8%	Explore
ionocyte	6 studies	28% ± 10%	Explore
respiratory goblet cell	6 studies	29% ± 21%	Explore
classical monocyte	6 studies	24% ± 8%	Explore
kidney loop of Henle epithelial cell	6 studies	53% ± 12%	Explore
erythroblast	6 studies	53% ± 21%	Explore
myofibroblast cell	6 studies	23% ± 5%	Explore
transit amplifying cell	6 studies	47% ± 23%	Explore
T follicular helper cell	6 studies	23% ± 3%	Explore
endothelial cell of lymphatic vessel	6 studies	21% ± 6%	Explore
plasmacytoid dendritic cell	6 studies	24% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	27% ± 3%	Explore
non-classical monocyte	5 studies	32% ± 9%	Explore
renal alpha-intercalated cell	5 studies	53% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	62% ± 7%	Explore
neuron	5 studies	29% ± 14%	Explore
enteroendocrine cell	5 studies	52% ± 21%	Explore
intestinal crypt stem cell	5 studies	51% ± 16%	Explore
brush cell	5 studies	21% ± 8%	Explore
erythrocyte	5 studies	56% ± 22%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	26% ± 6%	Explore
endothelial cell of vascular tree	5 studies	20% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	27% ± 10%	Explore
innate lymphoid cell	5 studies	25% ± 4%	Explore
hematopoietic precursor cell	4 studies	46% ± 15%	Explore
leukocyte	4 studies	28% ± 10%	Explore
exhausted T cell	4 studies	31% ± 10%	Explore
endothelial cell of artery	4 studies	17% ± 1%	Explore
retinal ganglion cell	4 studies	64% ± 26%	Explore
precursor B cell	4 studies	26% ± 12%	Explore
pro-B cell	4 studies	26% ± 7%	Explore
amacrine cell	4 studies	35% ± 14%	Explore
astrocyte	4 studies	27% ± 12%	Explore
microglial cell	4 studies	26% ± 12%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	32% ± 6%	Explore
hepatocyte	4 studies	49% ± 32%	Explore
glutamatergic neuron	4 studies	35% ± 10%	Explore
oligodendrocyte precursor cell	4 studies	24% ± 10%	Explore
T-helper 17 cell	4 studies	26% ± 6%	Explore
deuterosomal cell	3 studies	33% ± 1%	Explore
duct epithelial cell	3 studies	28% ± 1%	Explore
pancreatic A cell	3 studies	78% ± 6%	Explore
pancreatic D cell	3 studies	63% ± 13%	Explore
type B pancreatic cell	3 studies	53% ± 14%	Explore
mononuclear phagocyte	3 studies	24% ± 12%	Explore
neural crest cell	3 studies	19% ± 1%	Explore
renal principal cell	3 studies	42% ± 7%	Explore
placental villous trophoblast	3 studies	55% ± 26%	Explore
hematopoietic stem cell	3 studies	31% ± 5%	Explore
lymphocyte	3 studies	27% ± 8%	Explore
neuroendocrine cell	3 studies	44% ± 8%	Explore
retina horizontal cell	3 studies	35% ± 12%	Explore
retinal cone cell	3 studies	64% ± 15%	Explore
retinal rod cell	3 studies	32% ± 7%	Explore
alveolar macrophage	3 studies	20% ± 1%	Explore
mucus secreting cell	3 studies	53% ± 16%	Explore
Mueller cell	3 studies	29% ± 8%	Explore
germinal center B cell	3 studies	31% ± 3%	Explore
luminal cell of prostate epithelium	3 studies	49% ± 7%	Explore
GABAergic neuron	3 studies	29% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	37% ± 10%	Explore
T-helper 1 cell	3 studies	25% ± 4%	Explore
double negative thymocyte	3 studies	39% ± 21%	Explore
progenitor cell of mammary luminal epithelium	3 studies	27% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	14 studies	27% ± 12%	Explore
peripheral blood	12 studies	24% ± 10%	Explore
intestine	12 studies	29% ± 14%	Explore
kidney	9 studies	31% ± 10%	Explore
liver	7 studies	36% ± 23%	Explore
brain	7 studies	26% ± 7%	Explore
eye	6 studies	29% ± 12%	Explore
lymph node	5 studies	27% ± 13%	Explore
bone marrow	4 studies	21% ± 5%	Explore
uterus	4 studies	25% ± 13%	Explore
breast	4 studies	26% ± 3%	Explore
pancreas	3 studies	60% ± 16%	Explore
placenta	3 studies	28% ± 16%	Explore
adrenal gland	3 studies	23% ± 3%	Explore
prostate	3 studies	27% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	4996.22	226 / 226	100%	220.22	406 / 406
prostate	100%	3427.89	245 / 245	100%	250.49	502 / 502
brain	100%	2929.84	2639 / 2642	100%	52.91	704 / 705
kidney	100%	4465.75	89 / 89	100%	102.85	898 / 901
uterus	100%	1153.81	170 / 170	100%	50.36	457 / 459
breast	100%	1843.00	459 / 459	99%	93.83	1111 / 1118
stomach	100%	3681.94	359 / 359	99%	64.09	284 / 286
thymus	99%	1281.93	649 / 653	100%	52.05	602 / 605
intestine	100%	2414.61	966 / 966	98%	68.51	518 / 527
adrenal gland	100%	3143.96	258 / 258	98%	59.70	226 / 230
ovary	100%	1195.27	180 / 180	98%	36.44	422 / 430
lung	99%	1322.56	572 / 578	99%	49.15	1141 / 1155
bladder	100%	1578.33	21 / 21	98%	54.51	492 / 504
pancreas	97%	1046.74	319 / 328	99%	49.75	176 / 178
esophagus	100%	1787.01	1445 / 1445	95%	38.07	173 / 183
skin	99%	1342.13	1792 / 1809	90%	27.79	424 / 472
adipose	100%	1831.94	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	51.31	29 / 29
muscle	100%	3624.82	803 / 803	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	66.79	1 / 1
blood vessel	100%	1817.09	1330 / 1335	0%	0	0 / 0
spleen	99%	999.17	239 / 241	0%	0	0 / 0
heart	98%	3630.06	847 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	35.54	44 / 45
peripheral blood	77%	1002.93	715 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	45%	9.66	36 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006850	Biological process	mitochondrial pyruvate transmembrane transport
GO_0006086	Biological process	acetyl-CoA biosynthetic process from pyruvate
GO_0035774	Biological process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO_0098800	Cellular component	inner mitochondrial membrane protein complex
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0050833	Molecular function	pyruvate transmembrane transporter activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

Gene name	MPC2
Protein name	Mitochondrial pyruvate carrier 2 (Brain protein 44) Mitochondrial pyruvate carrier
Synonyms	BRP44
Description	FUNCTION: Mediates the uptake of pyruvate into mitochondria. . FUNCTION: Mediates the uptake of pyruvate into mitochondria. .
Accessions	ENST00000458574.1 Q5R3B4 ENST00000367846.8 O95563 ENST00000271373.9

MPC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review