MEAF6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	32 studies	27% ± 7%	Explore
B cell	27 studies	25% ± 8%	Explore
CD8-positive, alpha-beta T cell	27 studies	26% ± 7%	Explore
CD4-positive, alpha-beta T cell	25 studies	24% ± 7%	Explore
regulatory T cell	20 studies	28% ± 7%	Explore
T cell	19 studies	25% ± 7%	Explore
fibroblast	18 studies	24% ± 8%	Explore
ciliated cell	17 studies	42% ± 17%	Explore
mature NK T cell	16 studies	26% ± 7%	Explore
naive B cell	15 studies	23% ± 6%	Explore
endothelial cell	15 studies	27% ± 11%	Explore
smooth muscle cell	15 studies	21% ± 5%	Explore
memory B cell	15 studies	25% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	27% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	23% ± 6%	Explore
pericyte	13 studies	24% ± 7%	Explore
gamma-delta T cell	13 studies	32% ± 10%	Explore
mast cell	11 studies	21% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	26% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	28% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	30% ± 9%	Explore
connective tissue cell	10 studies	25% ± 10%	Explore
mucosal invariant T cell	10 studies	26% ± 7%	Explore
basal cell	10 studies	32% ± 14%	Explore
type I pneumocyte	9 studies	26% ± 11%	Explore
conventional dendritic cell	9 studies	28% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	28% ± 9%	Explore
macrophage	8 studies	22% ± 5%	Explore
epithelial cell	8 studies	43% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	26% ± 7%	Explore
non-classical monocyte	7 studies	26% ± 10%	Explore
classical monocyte	7 studies	23% ± 8%	Explore
myofibroblast cell	7 studies	26% ± 3%	Explore
neuron	7 studies	39% ± 17%	Explore
T follicular helper cell	7 studies	29% ± 5%	Explore
plasmacytoid dendritic cell	7 studies	28% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	28% ± 3%	Explore
capillary endothelial cell	6 studies	20% ± 2%	Explore
abnormal cell	6 studies	29% ± 8%	Explore
endothelial cell of vascular tree	6 studies	19% ± 1%	Explore
astrocyte	6 studies	27% ± 7%	Explore
kidney loop of Henle epithelial cell	5 studies	22% ± 4%	Explore
precursor B cell	5 studies	28% ± 7%	Explore
endothelial cell of lymphatic vessel	5 studies	23% ± 5%	Explore
innate lymphoid cell	5 studies	25% ± 5%	Explore
GABAergic neuron	5 studies	33% ± 12%	Explore
oligodendrocyte precursor cell	5 studies	26% ± 5%	Explore
pancreatic A cell	4 studies	48% ± 9%	Explore
type B pancreatic cell	4 studies	48% ± 13%	Explore
leukocyte	4 studies	24% ± 6%	Explore
exhausted T cell	4 studies	33% ± 3%	Explore
monocyte	4 studies	21% ± 6%	Explore
endothelial cell of artery	4 studies	20% ± 2%	Explore
pro-B cell	4 studies	25% ± 3%	Explore
immature B cell	4 studies	24% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	43% ± 6%	Explore
luminal cell of prostate epithelium	4 studies	38% ± 15%	Explore
glutamatergic neuron	4 studies	49% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	27% ± 8%	Explore
enteroendocrine cell	4 studies	29% ± 19%	Explore
goblet cell	4 studies	24% ± 10%	Explore
secretory cell	4 studies	26% ± 15%	Explore
oligodendrocyte	4 studies	23% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	28% ± 8%	Explore
hematopoietic precursor cell	3 studies	31% ± 7%	Explore
deuterosomal cell	3 studies	24% ± 4%	Explore
pancreatic D cell	3 studies	54% ± 14%	Explore
glomerular endothelial cell	3 studies	18% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	27% ± 7%	Explore
vein endothelial cell	3 studies	20% ± 1%	Explore
retinal ganglion cell	3 studies	73% ± 19%	Explore
plasma cell	3 studies	28% ± 6%	Explore
club cell	3 studies	27% ± 9%	Explore
type II pneumocyte	3 studies	25% ± 10%	Explore
amacrine cell	3 studies	42% ± 17%	Explore
intraepithelial lymphocyte	3 studies	33% ± 13%	Explore
Mueller cell	3 studies	24% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	31% ± 4%	Explore
dendritic cell	3 studies	44% ± 17%	Explore
pancreatic ductal cell	3 studies	44% ± 11%	Explore
intestinal crypt stem cell	3 studies	21% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	31% ± 11%	Explore
T-helper 17 cell	3 studies	24% ± 2%	Explore
interneuron	3 studies	34% ± 15%	Explore
mononuclear phagocyte	3 studies	28% ± 13%	Explore
T-helper 1 cell	3 studies	26% ± 5%	Explore
hematopoietic stem cell	3 studies	25% ± 7%	Explore
double negative thymocyte	3 studies	39% ± 9%	Explore
progenitor cell of mammary luminal epithelium	3 studies	19% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	26% ± 6%	Explore
lung	11 studies	27% ± 10%	Explore
intestine	7 studies	21% ± 10%	Explore
brain	6 studies	32% ± 11%	Explore
kidney	5 studies	22% ± 4%	Explore
eye	5 studies	25% ± 11%	Explore
lymph node	5 studies	25% ± 3%	Explore
pancreas	4 studies	43% ± 14%	Explore
liver	4 studies	28% ± 17%	Explore
prostate	3 studies	25% ± 4%	Explore
breast	3 studies	23% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2748.86	1445 / 1445	100%	25.88	183 / 183
ovary	100%	2984.51	180 / 180	100%	47.63	430 / 430
prostate	100%	5696.11	245 / 245	100%	81.83	502 / 502
brain	100%	3838.48	2641 / 2642	100%	37.45	705 / 705
breast	100%	3117.36	459 / 459	100%	62.87	1116 / 1118
lung	100%	2690.81	577 / 578	100%	34.93	1154 / 1155
uterus	100%	3082.02	170 / 170	100%	39.28	457 / 459
thymus	100%	2795.34	653 / 653	100%	59.07	602 / 605
bladder	100%	3222.00	21 / 21	99%	35.19	500 / 504
skin	100%	3173.58	1809 / 1809	99%	32.29	468 / 472
kidney	100%	2500.20	89 / 89	98%	26.83	887 / 901
stomach	100%	2154.42	359 / 359	98%	25.68	281 / 286
intestine	100%	2942.97	966 / 966	98%	27.28	516 / 527
pancreas	99%	1728.94	325 / 328	98%	32.17	175 / 178
adrenal gland	100%	2398.45	258 / 258	97%	32.12	222 / 230
liver	100%	1373.87	226 / 226	96%	22.97	390 / 406
adipose	100%	2653.74	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3424.01	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	25.53	29 / 29
spleen	100%	2263.60	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	27.36	45 / 45
ureter	0%	0	0 / 0	100%	21.62	1 / 1
muscle	100%	2129.20	802 / 803	0%	0	0 / 0
heart	98%	1511.30	843 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	93%	18.21	74 / 80
peripheral blood	89%	1493.02	824 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1903706	Biological process	regulation of hemopoiesis
GO_0001558	Biological process	regulation of cell growth
GO_2000779	Biological process	regulation of double-strand break repair
GO_0006338	Biological process	chromatin remodeling
GO_0042981	Biological process	regulation of apoptotic process
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_2000278	Biological process	regulation of DNA biosynthetic process
GO_1905168	Biological process	positive regulation of double-strand break repair via homologous recombination
GO_0006275	Biological process	regulation of DNA replication
GO_0050793	Biological process	regulation of developmental process
GO_0051726	Biological process	regulation of cell cycle
GO_0005730	Cellular component	nucleolus
GO_0000786	Cellular component	nucleosome
GO_0000776	Cellular component	kinetochore
GO_0005654	Cellular component	nucleoplasm
GO_0035267	Cellular component	NuA4 histone acetyltransferase complex
GO_0070776	Cellular component	MOZ/MORF histone acetyltransferase complex
GO_0000123	Cellular component	histone acetyltransferase complex
GO_0005634	Cellular component	nucleus
GO_0043997	Molecular function	histone H4K12 acetyltransferase activity
GO_0036408	Molecular function	histone H3K14 acetyltransferase activity
GO_0043996	Molecular function	histone H4K8 acetyltransferase activity
GO_0043995	Molecular function	histone H4K5 acetyltransferase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	MEAF6
Protein name	Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) (hEAF6) (Sarcoma antigen NY-SAR-91) Chromatin modification-related protein MEAF6
Synonyms	hCG_25685 EAF6 CENP-28 C1orf149
Description	FUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A . This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription . Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 . Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity . . FUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. .
Accessions	ENST00000448519.2 [Q9HAF1-2] B1AK63 ENST00000296214.10 [Q9HAF1-1] Q9HAF1 ENST00000373074.5 ENST00000373073.8 [Q9HAF1-4] ENST00000373075.6 [Q9HAF1-3]

MEAF6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review