MAP1LC3B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000045Biological processautophagosome assembly
GO_0016236Biological processmacroautophagy
GO_0009267Biological processcellular response to starvation
GO_0000422Biological processautophagy of mitochondrion
GO_0000423Biological processmitophagy
GO_0006914Biological processautophagy
GO_0097352Biological processautophagosome maturation
GO_0006995Biological processcellular response to nitrogen starvation
GO_0005874Cellular componentmicrotubule
GO_0031410Cellular componentcytoplasmic vesicle
GO_0012505Cellular componentendomembrane system
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0000421Cellular componentautophagosome membrane
GO_0005930Cellular componentaxoneme
GO_0005829Cellular componentcytosol
GO_0005776Cellular componentautophagosome
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0031090Cellular componentorganelle membrane
GO_0097001Molecular functionceramide binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0008017Molecular functionmicrotubule binding
GO_0008429Molecular functionphosphatidylethanolamine binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAP1LC3B
Protein nameMicrotubule associated protein 1 light chain 3 beta
MAP1LC3B protein (Microtubule-associated protein 1 light chain 3 beta, isoform CRA_b)
Microtubule-associated protein 1 light chain 3 beta, isoform CRA_c (cDNA FLJ77661, highly similar to Homo sapiens microtubule-associated protein 1 light chain 3 beta(MAP1LC3B), mRNA)
Microtubule associated protein 1 light chain 3 beta (Microtubule-associated protein 1 light chain 3 beta, isoform CRA_f)
MAP1LC3B-a (Microtubule-associated protein 1 light chain 3 beta, isoform CRA_e)
Microtubule-associated proteins 1A/1B light chain 3B (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (MAP1A/MAP1B light chain 3 B) (MAP1A/MAP1B LC3 B) (Microtubule-associated protein 1 light chain 3 beta)
SynonymsMAP1ALC3
DKFZp762B153
hCG_32374
DescriptionFUNCTION: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) . Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production . In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria . While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation . Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway . Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover . Upon nutrient stress, directly recruits cofactor JMY to the phagophore membrane surfaces and promotes JMY's actin nucleation activity and autophagosome biogenesis during autophagy . .

AccessionsH3BM99
ENST00000650688.1
ENST00000570189.5
H3BTE7
Q658J6
ENST00000565788.1
Q49A36
H6UMI0
H3BTL1
ENST00000564844.1
Q9GZQ8
ENST00000268607.10