LITAF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010935Biological processregulation of macrophage cytokine production
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0001817Biological processregulation of cytokine production
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005886Cellular componentplasma membrane
GO_0098560Cellular componentcytoplasmic side of late endosome membrane
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0098559Cellular componentcytoplasmic side of early endosome membrane
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0098574Cellular componentcytoplasmic side of lysosomal membrane
GO_0000139Cellular componentGolgi membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005765Cellular componentlysosomal membrane
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0042802Molecular functionidentical protein binding
GO_0050699Molecular functionWW domain binding
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLITAF
Protein nameLipopolysaccharide induced TNF factor
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein)
SynonymsSIMPLE
PIG7
DescriptionFUNCTION: Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation . Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps down-regulate downstream signaling cascades . Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes . Probably plays a role in regulating protein degradation via its interaction with NEDD4 . May also contribute to the regulation of gene expression in the nucleus . Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines . May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 . .

AccessionsI3L2T1
ENST00000622633.5 [Q99732-1]
Q99732
ENST00000571277.1
ENST00000576334.1
I3L2T6
ENST00000570798.5
I3L1I9
ENST00000571627.5
ENST00000570904.5 [Q99732-1]
ENST00000571459.5
I3L1P1
ENST00000574701.5
ENST00000574703.5
ENST00000573332.5
I3L329
I3L133
I3L409
ENST00000574848.5
I3L1R0
A0A0G2JLC4
ENST00000413364.6 [Q99732-3]
ENST00000576036.5 [Q99732-1]
I3L1H3
ENST00000571976.1
I3L3U8
ENST00000574763.5 [Q99732-1]
ENST00000572255.5
ENST00000571688.5 [Q99732-1]
I3L2E2
ENST00000339430.9 [Q99732-1]
ENST00000575426.1