LAPTM5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	52 studies	69% ± 25%	Explore
B cell	50 studies	75% ± 22%	Explore
natural killer cell	43 studies	56% ± 17%	Explore
CD8-positive, alpha-beta T cell	38 studies	62% ± 19%	Explore
T cell	37 studies	55% ± 21%	Explore
CD4-positive, alpha-beta T cell	32 studies	67% ± 19%	Explore
conventional dendritic cell	31 studies	76% ± 18%	Explore
classical monocyte	29 studies	81% ± 16%	Explore
monocyte	28 studies	67% ± 22%	Explore
regulatory T cell	28 studies	72% ± 17%	Explore
dendritic cell	27 studies	63% ± 28%	Explore
mast cell	27 studies	62% ± 20%	Explore
non-classical monocyte	26 studies	85% ± 14%	Explore
endothelial cell of lymphatic vessel	24 studies	47% ± 20%	Explore
plasmacytoid dendritic cell	23 studies	71% ± 14%	Explore
mature NK T cell	21 studies	55% ± 19%	Explore
gamma-delta T cell	20 studies	61% ± 18%	Explore
memory B cell	20 studies	88% ± 8%	Explore
naive B cell	20 studies	87% ± 14%	Explore
myeloid cell	19 studies	62% ± 26%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	65% ± 18%	Explore
neutrophil	17 studies	60% ± 15%	Explore
mucosal invariant T cell	16 studies	71% ± 19%	Explore
microglial cell	16 studies	54% ± 23%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	73% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	66% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	53% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	66% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	67% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	58% ± 18%	Explore
plasma cell	12 studies	46% ± 19%	Explore
leukocyte	12 studies	58% ± 18%	Explore
innate lymphoid cell	10 studies	48% ± 19%	Explore
plasmablast	10 studies	59% ± 19%	Explore
T follicular helper cell	10 studies	67% ± 14%	Explore
platelet	9 studies	42% ± 16%	Explore
alveolar macrophage	8 studies	75% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	60% ± 23%	Explore
mononuclear phagocyte	8 studies	65% ± 23%	Explore
precursor B cell	7 studies	83% ± 17%	Explore
immature B cell	7 studies	83% ± 23%	Explore
CD4-positive helper T cell	6 studies	59% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	77% ± 22%	Explore
endothelial cell	6 studies	27% ± 15%	Explore
hematopoietic stem cell	6 studies	68% ± 21%	Explore
intermediate monocyte	6 studies	79% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	68% ± 17%	Explore
erythrocyte	6 studies	48% ± 24%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	65% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	62% ± 16%	Explore
hematopoietic precursor cell	5 studies	70% ± 10%	Explore
exhausted T cell	5 studies	77% ± 10%	Explore
megakaryocyte	5 studies	66% ± 18%	Explore
pro-B cell	5 studies	85% ± 9%	Explore
T-helper 17 cell	5 studies	77% ± 12%	Explore
group 3 innate lymphoid cell	5 studies	67% ± 15%	Explore
inflammatory macrophage	5 studies	63% ± 18%	Explore
double negative thymocyte	5 studies	68% ± 13%	Explore
granulocyte	5 studies	71% ± 13%	Explore
lymphocyte	4 studies	47% ± 15%	Explore
germinal center B cell	4 studies	79% ± 15%	Explore
IgG plasma cell	4 studies	21% ± 8%	Explore
T-helper 1 cell	4 studies	84% ± 4%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	72% ± 15%	Explore
Langerhans cell	3 studies	65% ± 26%	Explore
monocyte-derived dendritic cell	3 studies	88% ± 7%	Explore
thymocyte	3 studies	43% ± 11%	Explore
erythroblast	3 studies	38% ± 12%	Explore
tissue-resident macrophage	3 studies	75% ± 22%	Explore
intraepithelial lymphocyte	3 studies	53% ± 12%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	72% ± 16%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	75% ± 14%	Explore
double-positive, alpha-beta thymocyte	3 studies	74% ± 21%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	71% ± 17%	Explore
lung	15 studies	35% ± 16%	Explore
bone marrow	7 studies	39% ± 25%	Explore
intestine	6 studies	29% ± 12%	Explore
kidney	5 studies	40% ± 27%	Explore
lymph node	5 studies	64% ± 23%	Explore
liver	5 studies	40% ± 19%	Explore
brain	4 studies	48% ± 25%	Explore
adrenal gland	3 studies	41% ± 21%	Explore
placenta	3 studies	26% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	23540.90	578 / 578	95%	145.98	1092 / 1155
breast	95%	6401.27	435 / 459	97%	126.77	1082 / 1118
thymus	81%	4140.73	530 / 653	81%	77.81	490 / 605
intestine	77%	6357.68	743 / 966	80%	83.94	420 / 527
bladder	76%	4192.81	16 / 21	74%	82.54	375 / 504
stomach	54%	2202.84	195 / 359	84%	108.96	241 / 286
adrenal gland	90%	5764.26	232 / 258	48%	29.94	111 / 230
prostate	69%	3147.61	170 / 245	64%	32.22	323 / 502
kidney	43%	2476.56	38 / 89	90%	139.70	814 / 901
brain	34%	2052.34	909 / 2642	95%	176.76	670 / 705
uterus	47%	1626.16	80 / 170	81%	69.29	374 / 459
esophagus	51%	2068.86	742 / 1445	77%	61.34	141 / 183
skin	25%	801.41	455 / 1809	84%	121.31	398 / 472
ovary	22%	830.47	40 / 180	86%	113.10	370 / 430
pancreas	16%	751.43	52 / 328	92%	135.73	163 / 178
lymph node	0%	0	0 / 0	100%	1083.62	29 / 29
peripheral blood	100%	124098.50	929 / 929	0%	0	0 / 0
spleen	100%	50771.08	241 / 241	0%	0	0 / 0
adipose	99%	11066.26	1195 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	128.31	41 / 45
liver	29%	1241.70	66 / 226	57%	37.23	230 / 406
blood vessel	74%	6274.73	987 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	31%	19.48	25 / 80
heart	27%	1202.83	235 / 861	0%	0	0 / 0
muscle	1%	28.57	7 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006919	Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO_1901224	Biological process	positive regulation of non-canonical NF-kappaB signal transduction
GO_1903265	Biological process	positive regulation of tumor necrosis factor-mediated signaling pathway
GO_0006622	Biological process	protein targeting to lysosome
GO_0032703	Biological process	negative regulation of interleukin-2 production
GO_0050860	Biological process	negative regulation of T cell receptor signaling pathway
GO_0002720	Biological process	positive regulation of cytokine production involved in immune response
GO_0032735	Biological process	positive regulation of interleukin-12 production
GO_0050868	Biological process	negative regulation of T cell activation
GO_0006886	Biological process	intracellular protein transport
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_2000646	Biological process	positive regulation of receptor catabolic process
GO_2000060	Biological process	positive regulation of ubiquitin-dependent protein catabolic process
GO_0090160	Biological process	Golgi to lysosome transport
GO_0002357	Biological process	defense response to tumor cell
GO_0060907	Biological process	positive regulation of macrophage cytokine production
GO_0032689	Biological process	negative regulation of type II interferon production
GO_0031398	Biological process	positive regulation of protein ubiquitination
GO_0097214	Biological process	positive regulation of lysosomal membrane permeability
GO_0012502	Biological process	induction of programmed cell death
GO_1904093	Biological process	negative regulation of autophagic cell death
GO_0050869	Biological process	negative regulation of B cell activation
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005764	Cellular component	lysosome
GO_0032991	Cellular component	protein-containing complex
GO_0005829	Cellular component	cytosol
GO_0030133	Cellular component	transport vesicle
GO_0005765	Cellular component	lysosomal membrane
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0140311	Molecular function	protein sequestering activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LAPTM5
Protein name	Lysosomal-associated transmembrane protein 5 (Lysosomal-associated multitransmembrane protein 5) (Retinoic acid-inducible E3 protein) Lysosomal associated multispanning membrane protein 5, isoform CRA_a (Lysosomal multispanning membrane protein 5) (cDNA FLJ75768, highly similar to Homo sapiens lysosomal associated multispanning membrane protein 5 (LAPTM5), mRNA)
Synonyms	hCG_15079 KIAA0085
Description	FUNCTION: May have a special functional role during embryogenesis and in adult hematopoietic cells. .
Accessions	ENST00000294507.4 Q5TBB8 Q13571

LAPTM5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review