H2AZ2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	35 studies	36% ± 14%	Explore
CD8-positive, alpha-beta T cell	31 studies	39% ± 18%	Explore
B cell	30 studies	32% ± 16%	Explore
endothelial cell	30 studies	29% ± 12%	Explore
CD4-positive, alpha-beta T cell	30 studies	38% ± 18%	Explore
T cell	29 studies	42% ± 18%	Explore
macrophage	28 studies	30% ± 11%	Explore
fibroblast	25 studies	27% ± 10%	Explore
conventional dendritic cell	25 studies	42% ± 16%	Explore
regulatory T cell	22 studies	39% ± 9%	Explore
plasmacytoid dendritic cell	20 studies	46% ± 15%	Explore
dendritic cell	19 studies	40% ± 23%	Explore
classical monocyte	19 studies	34% ± 14%	Explore
mast cell	18 studies	35% ± 14%	Explore
smooth muscle cell	18 studies	29% ± 10%	Explore
epithelial cell	18 studies	39% ± 20%	Explore
pericyte	18 studies	27% ± 8%	Explore
non-classical monocyte	17 studies	32% ± 16%	Explore
ciliated cell	17 studies	38% ± 21%	Explore
monocyte	16 studies	34% ± 9%	Explore
memory B cell	16 studies	23% ± 5%	Explore
gamma-delta T cell	15 studies	38% ± 17%	Explore
mature NK T cell	14 studies	33% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	37% ± 10%	Explore
basal cell	13 studies	32% ± 19%	Explore
naive B cell	13 studies	21% ± 6%	Explore
plasma cell	12 studies	43% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	30% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	32% ± 10%	Explore
connective tissue cell	12 studies	35% ± 11%	Explore
myeloid cell	12 studies	43% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	41% ± 15%	Explore
mucosal invariant T cell	11 studies	31% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	36% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	35% ± 11%	Explore
capillary endothelial cell	10 studies	24% ± 10%	Explore
myofibroblast cell	10 studies	30% ± 9%	Explore
endothelial cell of artery	10 studies	24% ± 8%	Explore
endothelial cell of lymphatic vessel	9 studies	27% ± 9%	Explore
plasmablast	9 studies	57% ± 26%	Explore
effector CD8-positive, alpha-beta T cell	9 studies	38% ± 13%	Explore
innate lymphoid cell	9 studies	40% ± 13%	Explore
neuron	9 studies	29% ± 14%	Explore
vein endothelial cell	9 studies	25% ± 11%	Explore
leukocyte	8 studies	40% ± 15%	Explore
progenitor cell	8 studies	46% ± 19%	Explore
abnormal cell	8 studies	35% ± 14%	Explore
endothelial cell of vascular tree	8 studies	22% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	40% ± 13%	Explore
goblet cell	7 studies	35% ± 15%	Explore
T follicular helper cell	7 studies	36% ± 7%	Explore
precursor B cell	7 studies	49% ± 20%	Explore
type I pneumocyte	6 studies	28% ± 10%	Explore
hematopoietic precursor cell	6 studies	63% ± 18%	Explore
ionocyte	6 studies	30% ± 13%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	33% ± 8%	Explore
glutamatergic neuron	6 studies	33% ± 18%	Explore
transit amplifying cell	6 studies	47% ± 20%	Explore
astrocyte	6 studies	24% ± 5%	Explore
oligodendrocyte precursor cell	6 studies	32% ± 9%	Explore
CD4-positive helper T cell	5 studies	32% ± 14%	Explore
club cell	5 studies	31% ± 9%	Explore
exhausted T cell	5 studies	44% ± 14%	Explore
mononuclear phagocyte	5 studies	41% ± 15%	Explore
kidney loop of Henle epithelial cell	5 studies	20% ± 4%	Explore
enteroendocrine cell	5 studies	38% ± 11%	Explore
mesothelial cell	5 studies	35% ± 13%	Explore
hematopoietic stem cell	5 studies	48% ± 7%	Explore
pro-B cell	5 studies	61% ± 12%	Explore
brush cell	5 studies	29% ± 15%	Explore
type II pneumocyte	5 studies	28% ± 12%	Explore
retinal cone cell	5 studies	47% ± 25%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	45% ± 17%	Explore
granulocyte	5 studies	36% ± 13%	Explore
deuterosomal cell	4 studies	50% ± 14%	Explore
enterocyte	4 studies	25% ± 5%	Explore
erythroblast	4 studies	67% ± 22%	Explore
lymphocyte	4 studies	45% ± 25%	Explore
amacrine cell	4 studies	29% ± 9%	Explore
retina horizontal cell	4 studies	35% ± 12%	Explore
retinal rod cell	4 studies	27% ± 6%	Explore
alveolar macrophage	4 studies	18% ± 1%	Explore
erythrocyte	4 studies	49% ± 30%	Explore
neutrophil	4 studies	22% ± 6%	Explore
germinal center B cell	4 studies	50% ± 13%	Explore
intermediate monocyte	4 studies	43% ± 23%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	32% ± 7%	Explore
GABAergic neuron	4 studies	34% ± 12%	Explore
T-helper 17 cell	4 studies	51% ± 22%	Explore
oligodendrocyte	4 studies	23% ± 4%	Explore
precursor cell	3 studies	52% ± 23%	Explore
secretory cell	3 studies	44% ± 25%	Explore
pancreatic A cell	3 studies	33% ± 9%	Explore
monocyte-derived dendritic cell	3 studies	40% ± 15%	Explore
glomerular endothelial cell	3 studies	20% ± 1%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	39% ± 7%	Explore
epithelial cell of proximal tubule	3 studies	21% ± 4%	Explore
intestinal crypt stem cell	3 studies	35% ± 7%	Explore
neural crest cell	3 studies	63% ± 18%	Explore
retinal bipolar neuron	3 studies	38% ± 10%	Explore
extravillous trophoblast	3 studies	35% ± 23%	Explore
neuroendocrine cell	3 studies	46% ± 20%	Explore
immature B cell	3 studies	50% ± 14%	Explore
retinal pigment epithelial cell	3 studies	33% ± 13%	Explore
serous secreting cell	3 studies	21% ± 2%	Explore
Mueller cell	3 studies	32% ± 5%	Explore
rod bipolar cell	3 studies	33% ± 10%	Explore
muscle cell	3 studies	30% ± 9%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	75% ± 15%	Explore
glial cell	3 studies	39% ± 21%	Explore
group 3 innate lymphoid cell	3 studies	53% ± 15%	Explore
keratinocyte	3 studies	20% ± 5%	Explore
interneuron	3 studies	35% ± 17%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	49% ± 7%	Explore
double negative thymocyte	3 studies	53% ± 20%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	35% ± 15%	Explore
peripheral blood	14 studies	35% ± 13%	Explore
intestine	11 studies	29% ± 12%	Explore
brain	10 studies	27% ± 10%	Explore
kidney	8 studies	27% ± 8%	Explore
eye	8 studies	27% ± 9%	Explore
liver	6 studies	35% ± 22%	Explore
lymph node	6 studies	38% ± 13%	Explore
bone marrow	5 studies	33% ± 9%	Explore
uterus	4 studies	32% ± 15%	Explore
breast	4 studies	25% ± 7%	Explore
thymus	3 studies	58% ± 29%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	9568.20	2642 / 2642	100%	150.53	705 / 705
breast	100%	5362.70	459 / 459	100%	99.36	1118 / 1118
esophagus	100%	6783.03	1445 / 1445	100%	89.51	183 / 183
lung	100%	6346.22	578 / 578	100%	84.29	1155 / 1155
ovary	100%	5870.48	180 / 180	100%	68.91	430 / 430
prostate	100%	6159.80	245 / 245	100%	81.01	502 / 502
stomach	100%	5279.05	359 / 359	100%	81.82	286 / 286
uterus	100%	7302.62	170 / 170	100%	100.15	459 / 459
thymus	100%	6371.54	653 / 653	100%	81.32	604 / 605
intestine	100%	8455.56	966 / 966	100%	81.70	526 / 527
bladder	100%	6268.24	21 / 21	100%	76.89	502 / 504
kidney	100%	5719.01	89 / 89	100%	75.03	897 / 901
liver	100%	3211.25	226 / 226	99%	49.06	403 / 406
skin	100%	4889.89	1807 / 1809	99%	86.39	468 / 472
adrenal gland	100%	5332.21	258 / 258	99%	64.16	227 / 230
pancreas	98%	2813.65	323 / 328	99%	62.19	176 / 178
adipose	100%	5261.30	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7759.87	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	91.93	29 / 29
muscle	100%	8397.93	803 / 803	0%	0	0 / 0
spleen	100%	5404.39	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	102.45	45 / 45
ureter	0%	0	0 / 0	100%	40.03	1 / 1
heart	99%	6628.76	851 / 861	0%	0	0 / 0
peripheral blood	96%	4182.56	888 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	90%	35.92	72 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0008150	Biological process	biological_process
GO_0031507	Biological process	heterochromatin formation
GO_0070062	Cellular component	extracellular exosome
GO_0000786	Cellular component	nucleosome
GO_0005634	Cellular component	nucleus
GO_0046982	Molecular function	protein heterodimerization activity
GO_0031492	Molecular function	nucleosomal DNA binding
GO_0060090	Molecular function	molecular adaptor activity
GO_0030527	Molecular function	structural constituent of chromatin
GO_0003674	Molecular function	molecular_function

IV. Literature review

[source]

Gene name	H2AZ2
Protein name	Histone H2A Histone H2A.V (H2A.F/Z) (H2A.Z variant histone 2) H2A.Z variant histone 2
Synonyms	H2AV H2AFV
Description	FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). .
Accessions	Q71UI9 ENST00000437072.5 ENST00000350771.7 [Q71UI9-4] ENST00000521529.5 ENST00000349299.7 [Q71UI9-3] ENST00000308153.9 [Q71UI9-1] E5RJU1 ENST00000222690.10 [Q71UI9-2] C9J0D1 ENST00000446531.1 C9J386 ENST00000381124.9 [Q71UI9-5]

H2AZ2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review