FBL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048254Biological processsnoRNA localization
GO_0001649Biological processosteoblast differentiation
GO_0031167Biological processrRNA methylation
GO_0006338Biological processchromatin remodeling
GO_0042274Biological processribosomal small subunit biogenesis
GO_0006364Biological processrRNA processing
GO_0000494Biological processbox C/D sno(s)RNA 3'-end processing
GO_0005730Cellular componentnucleolus
GO_0001652Cellular componentgranular component
GO_0016020Cellular componentmembrane
GO_0032040Cellular componentsmall-subunit processome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0015030Cellular componentCajal body
GO_0031428Cellular componentbox C/D methylation guide snoRNP complex
GO_0005634Cellular componentnucleus
GO_0001094Molecular functionTFIID-class transcription factor complex binding
GO_0180021Molecular functionU6 snRNA 2'-O-ribose methyltransferase activity
GO_1990259Molecular functionhistone H2AQ104 methyltransferase activity
GO_0008649Molecular functionrRNA methyltransferase activity
GO_0051117Molecular functionATPase binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBL
Protein namerRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (34 kDa nucleolar scleroderma antigen) (Histone-glutamine methyltransferase) (U6 snRNA 2'-O-methyltransferase fibrillarin)
Fibrillarin
FBL protein
SynonymsFLRN
FIB1
DescriptionFUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins . Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA . Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes . U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity . Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus . Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . .

AccessionsM0QXL5
ENST00000598417.5
ENST00000628079
M0R2Q4
ENST00000597634.5
ENST00000597224.5
ENST00000630954
ENST00000601274.5
M0R2B0
ENST00000625673
ENST00000629964
M0R299
ENST00000630592
ENST00000625241.3
M0R2U2
ENST00000594443.5
M0R0P1
ENST00000595545.5
ENST00000599134.1
ENST00000221801.8
ENST00000594309.5
Q96BS4
ENST00000629606
P22087
M0R1H0
M0QXC9
ENST00000629982
ENST00000627797