EIF4H | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	33 studies	30% ± 12%	Explore
fibroblast	31 studies	30% ± 13%	Explore
B cell	30 studies	27% ± 8%	Explore
natural killer cell	28 studies	31% ± 9%	Explore
conventional dendritic cell	24 studies	32% ± 19%	Explore
pericyte	23 studies	32% ± 11%	Explore
smooth muscle cell	23 studies	31% ± 13%	Explore
CD8-positive, alpha-beta T cell	23 studies	31% ± 10%	Explore
CD4-positive, alpha-beta T cell	22 studies	33% ± 12%	Explore
T cell	21 studies	28% ± 10%	Explore
classical monocyte	20 studies	30% ± 15%	Explore
regulatory T cell	20 studies	33% ± 7%	Explore
macrophage	19 studies	25% ± 8%	Explore
memory B cell	18 studies	28% ± 9%	Explore
non-classical monocyte	18 studies	29% ± 14%	Explore
basal cell	17 studies	29% ± 12%	Explore
naive B cell	17 studies	26% ± 8%	Explore
epithelial cell	16 studies	36% ± 20%	Explore
gamma-delta T cell	15 studies	31% ± 14%	Explore
mature NK T cell	14 studies	27% ± 7%	Explore
connective tissue cell	14 studies	34% ± 14%	Explore
mast cell	13 studies	23% ± 4%	Explore
monocyte	13 studies	26% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	33% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	28% ± 8%	Explore
endothelial cell of lymphatic vessel	12 studies	29% ± 9%	Explore
ciliated cell	12 studies	31% ± 13%	Explore
plasmacytoid dendritic cell	12 studies	27% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	30% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	31% ± 7%	Explore
myofibroblast cell	12 studies	37% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	31% ± 11%	Explore
capillary endothelial cell	11 studies	28% ± 13%	Explore
vein endothelial cell	11 studies	26% ± 10%	Explore
endothelial cell of vascular tree	11 studies	27% ± 6%	Explore
abnormal cell	10 studies	30% ± 11%	Explore
endothelial cell of artery	10 studies	24% ± 7%	Explore
dendritic cell	9 studies	42% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	32% ± 9%	Explore
mucosal invariant T cell	9 studies	32% ± 6%	Explore
myeloid cell	9 studies	35% ± 16%	Explore
plasma cell	8 studies	30% ± 12%	Explore
plasmablast	8 studies	45% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	31% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	29% ± 14%	Explore
hematopoietic stem cell	7 studies	41% ± 16%	Explore
precursor B cell	7 studies	47% ± 16%	Explore
type I pneumocyte	6 studies	32% ± 10%	Explore
type II pneumocyte	6 studies	26% ± 12%	Explore
secretory cell	6 studies	25% ± 9%	Explore
goblet cell	6 studies	27% ± 9%	Explore
innate lymphoid cell	6 studies	27% ± 5%	Explore
T follicular helper cell	6 studies	27% ± 4%	Explore
hematopoietic precursor cell	5 studies	56% ± 21%	Explore
leukocyte	5 studies	27% ± 7%	Explore
progenitor cell	5 studies	34% ± 7%	Explore
neuron	5 studies	37% ± 19%	Explore
enteroendocrine cell	5 studies	29% ± 11%	Explore
pro-B cell	5 studies	53% ± 14%	Explore
immature B cell	5 studies	32% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	34% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	34% ± 11%	Explore
pancreatic A cell	4 studies	55% ± 18%	Explore
exhausted T cell	4 studies	37% ± 9%	Explore
kidney loop of Henle epithelial cell	4 studies	20% ± 2%	Explore
mesothelial cell	4 studies	46% ± 14%	Explore
retinal ganglion cell	4 studies	62% ± 26%	Explore
astrocyte	4 studies	29% ± 13%	Explore
retina horizontal cell	4 studies	34% ± 14%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	29% ± 3%	Explore
granulocyte	4 studies	23% ± 5%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	55% ± 29%	Explore
erythrocyte	4 studies	41% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	24% ± 6%	Explore
precursor cell	3 studies	47% ± 15%	Explore
pancreatic D cell	3 studies	48% ± 26%	Explore
type B pancreatic cell	3 studies	57% ± 25%	Explore
mononuclear phagocyte	3 studies	30% ± 16%	Explore
glomerular endothelial cell	3 studies	22% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	33% ± 10%	Explore
renal alpha-intercalated cell	3 studies	28% ± 9%	Explore
enterocyte	3 studies	18% ± 1%	Explore
neural crest cell	3 studies	40% ± 9%	Explore
retinal bipolar neuron	3 studies	38% ± 12%	Explore
extravillous trophoblast	3 studies	58% ± 18%	Explore
placental villous trophoblast	3 studies	47% ± 15%	Explore
erythroblast	3 studies	61% ± 22%	Explore
lymphocyte	3 studies	36% ± 5%	Explore
club cell	3 studies	33% ± 7%	Explore
amacrine cell	3 studies	45% ± 9%	Explore
retinal cone cell	3 studies	45% ± 13%	Explore
retinal rod cell	3 studies	30% ± 9%	Explore
microglial cell	3 studies	24% ± 8%	Explore
Mueller cell	3 studies	29% ± 7%	Explore
germinal center B cell	3 studies	39% ± 11%	Explore
intermediate monocyte	3 studies	42% ± 23%	Explore
muscle cell	3 studies	31% ± 17%	Explore
oligodendrocyte	3 studies	23% ± 5%	Explore
pancreatic ductal cell	3 studies	65% ± 23%	Explore
oligodendrocyte precursor cell	3 studies	36% ± 9%	Explore
group 3 innate lymphoid cell	3 studies	41% ± 13%	Explore
transit amplifying cell	3 studies	24% ± 3%	Explore
T-helper 1 cell	3 studies	32% ± 5%	Explore
double negative thymocyte	3 studies	46% ± 13%	Explore
progenitor cell of mammary luminal epithelium	3 studies	25% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	15 studies	33% ± 10%	Explore
lung	14 studies	29% ± 11%	Explore
eye	8 studies	27% ± 11%	Explore
intestine	7 studies	28% ± 13%	Explore
kidney	6 studies	25% ± 6%	Explore
brain	6 studies	27% ± 10%	Explore
lymph node	5 studies	27% ± 9%	Explore
pancreas	4 studies	51% ± 23%	Explore
placenta	4 studies	36% ± 8%	Explore
bone marrow	4 studies	31% ± 15%	Explore
uterus	4 studies	30% ± 10%	Explore
breast	4 studies	26% ± 4%	Explore
liver	3 studies	35% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	15088.18	459 / 459	100%	141.29	1118 / 1118
esophagus	100%	17023.56	1445 / 1445	100%	124.91	183 / 183
lung	100%	13874.80	578 / 578	100%	132.78	1155 / 1155
ovary	100%	14738.81	180 / 180	100%	106.87	430 / 430
prostate	100%	13128.69	245 / 245	100%	138.61	502 / 502
skin	100%	19794.37	1809 / 1809	100%	157.96	472 / 472
brain	100%	13209.68	2640 / 2642	100%	169.36	705 / 705
stomach	100%	12961.82	359 / 359	100%	110.52	285 / 286
intestine	100%	15865.41	966 / 966	100%	122.57	525 / 527
pancreas	100%	10513.30	328 / 328	99%	112.87	177 / 178
bladder	100%	14993.52	21 / 21	99%	118.75	501 / 504
thymus	100%	12870.52	652 / 653	100%	142.86	602 / 605
kidney	100%	10779.79	89 / 89	99%	128.79	894 / 901
uterus	100%	15188.97	170 / 170	99%	135.37	455 / 459
adrenal gland	100%	14060.89	258 / 258	98%	93.73	225 / 230
liver	100%	8399.71	225 / 226	97%	75.12	395 / 406
adipose	100%	15679.89	1204 / 1204	0%	0	0 / 0
blood vessel	100%	16403.07	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	116.99	80 / 80
lymph node	0%	0	0 / 0	100%	137.02	29 / 29
muscle	100%	19710.23	803 / 803	0%	0	0 / 0
spleen	100%	11464.15	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	150.20	45 / 45
ureter	0%	0	0 / 0	100%	43.92	1 / 1
heart	97%	9188.57	836 / 861	0%	0	0 / 0
peripheral blood	96%	11252.60	888 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0048589	Biological process	developmental growth
GO_0006446	Biological process	regulation of translational initiation
GO_0006413	Biological process	translational initiation
GO_0019953	Biological process	sexual reproduction
GO_0005829	Cellular component	cytosol
GO_0016281	Cellular component	eukaryotic translation initiation factor 4F complex
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0003743	Molecular function	translation initiation factor activity
GO_0045296	Molecular function	cadherin binding
GO_0008135	Molecular function	translation factor activity, RNA binding
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	EIF4H
Protein name	Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) Eukaryotic translation initiation factor 4H
Synonyms	WBSCR1 KIAA0038 WSCR1
Description	FUNCTION: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. . FUNCTION: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. . FUNCTION: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. .
Accessions	ENST00000353999.6 [Q15056-2] A0A7I2V4E4 A0A7I2V385 ENST00000679266.1 A0A7I2V3E4 ENST00000677681.1 ENST00000678341.1 ENST00000677570.1 ENST00000679287.1 ENST00000678815.1 ENST00000678438.1 [Q15056-2] Q15056 ENST00000677998.1 A0A7I2V4V9 A0A7I2V3D5 ENST00000265753.13 [Q15056-1]

EIF4H report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review